Lanostane Triterpenoids from the Mushroom <i>Naematoloma fasciculare</i>

Kim, Ki‐Hyun; Moon, Eunjung; Choi, Sang Un; Kim, Sun Yeou; Lee, Kang Ro

doi:10.1021/np300801x

Cited by 60 publications

(34 citation statements)

References 23 publications

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“…Hot water extraction is for extracting water soluble materials such as polysaccharides, oligosaccharides, protein and enzymes [20], [21], [22], [23]. In contrast, ethanol or methanol is used for extracting terpenoids, alkaloids, etc [16], [17], [24]. In this study, we used a three time ethanol extraction to obtain crude products.…”

Section: Discussionmentioning

confidence: 99%

Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

et al. 2014

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Cancer is the second leading cause of death worldwide. Edible medicinal mushrooms have been used in traditional medicine as regimes for cancer patients. Recently anti-cancer bioactive components from some mushrooms have been isolated and their anti-cancer effects have been tested. Pleurotus ferulae, a typical edible medicinal mushroom in Xinjiang China, has also been used to treat cancer patients in folk medicine. However, little studies have been reported on the anti-cancer components of Pleurotus ferulae. This study aims to extract bioactive components from Pleurotus ferulae and to investigate the anti-cancer effects of the extracts. We used ethanol to extract anti-cancer bioactive components enriched with terpenoids from Pleurotus ferulae. We tested the anti-tumour effects of ethanol extracts on the melanoma cell line B16F10, the human gastric cancer cell line BGC 823 and the immortalized human gastric epithelial mucosa cell line GES-1 in vitro and a murine melanoma model in vivo. Cell toxicity and cell proliferation were measured by MTT assays. Cell cycle progression, apoptosis, caspase 3 activity, mitochondrial membrane potential (MMP), migration and gene expression were studied in vitro. PFEC suppressed tumor cell growth, inhibited cell proliferation, arrested cells at G0/G1 phases and was not toxic to non-cancer cells. PFEC also induced cell apoptosis and necrosis, increased caspase 3 activity, reduced the MMP, prevented cell invasion and changed the expression of genes associated with apoptosis and the cell cycle. PFEC delayed tumor formation and reduced tumor growth in vivo. In conclusion, ethanol extracted components from Pleurotus ferulae exert anti-cancer effects through direct suppression of tumor cell growth and invasion, demonstrating its therapeutic potential in cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

et al. 2014

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“…Ganoderma applanatum Activating NK cell [128] Ganolucidoid A and B Ganoderma lucidum NO production, anti-inflammatory activities [130] Lanostane Hypholoma fasciculare NO production, anti-inflammatory activities [151] The fungal immunomodulatory protein FIP-fve that was obtained from Flammulina velutipes has been employed to suppress the respiratory syncytial virus (RSV), which is known to cause bronchiolitis. FIP-fve effectively decreased RSV replication, IL-6 expression, and inflammation via inhibition of NF-κB translocation and respiratory pathogenesis in RSV-challenged mice.…”

Section: Exobiopolymersmentioning

confidence: 99%

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

et al. 2020

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The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.

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“…Compounds 53 and 54 displayed considerable cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 human cancer cell lines using the SRB bioassay (IC 50 (53) [40].…”

Section: (1h H-3); D C 833 (C-3)]mentioning

confidence: 99%

“…Thus, there are monoterpenoids (C 10 ), sesquiterpenoids (C 15 ), diterpenoids (C 20 ), sesterterpenoids (C 25 ), triterpenoids (C 30 ), and tetraterpenoids (C 40 ). Terpenoids are divided into families based on the number of isoprene units from which they are formed.…”

Section: Introductionmentioning

confidence: 99%