Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in LPS-induced BV-2 cells

Luo, Di; Xie, Jizhao; Zou, Luhui; Qiu, Li; Huang, Dongping; Xie, Yunfei; Xu, Huanji; Wu, Xinduo

doi:10.1016/j.phytochem.2020.112453

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…The anti-neuroinflammatory effect of compounds 1 – 29 was evaluated by LPS-induced BV2 microglia reported previously ( Luo et al, 2020 ). The BV2 microglia cells were plated into a 96-well plate.…”

Section: Methodsmentioning

confidence: 99%

Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms

et al. 2022

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Five new oleanane-type triterpenoid saponins (1–5), together with 24 known saponins (6–29) were isolated from the fruit of Acanthopanax senticosus. Their structures were determined by extensive spectroscopic analysis, including 1D, 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), in combination with chemical methods (acid hydrolysis). The neuroinflammation model was established by lipopolysaccharide (LPS)-induced BV2 microglia, and the neuroprotective effects of all compounds (1–29) were evaluated.

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Section: Methodsmentioning

confidence: 99%

Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms

et al. 2022

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“…Three unprecedented lanostane‐type triterpenes with antiinflammatory activities—applanoic acid E ( 24 ), 16,17‐dehydroapplanone E ( 25 ), and methyl applaniate B ( 26 )—were isolated from Ganoderma applanatum (D. Luo, Xie, et al, 2020). These terpenoids were evaluated of inhibitory activities on NO production using LPS‐induced BV‐2 cells, exhibiting IC 50 values of 40.25 ( 24 ), 8.95 ( 25 ), and 30.49 ( 26 ) μM.…”

Section: Antiinflammatory Activity Of Natural Triterpenesmentioning

confidence: 99%

Antiinflammatory activity of natural triterpenes—An overview from 2006 to 2021

Miranda

Jesus

Luiz

et al. 2022

Phytotherapy Research

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Terpenes are one of the most abundant classes of secondary metabolites produced by plants and can be divided based on the number of isoprene units (C5) in monoterpenes (2 units—C10), sesquiterpenes (3 units—C15), diterpenes (4 units—C20), triterpenes (6 units—C30), etc. Chemically, triterpenes are classified based on their structural skeleton including lanostanes, euphanes, cycloartanes, ursanes, oleananes, lupanes, tirucallanes, cucurbitanes, dammaranes, baccharanes, friedelanes, hopanes, serratanes etc. Additionally, glycosylated (saponins) or highly oxidated/degraded (limonoids) triterpenes could be found in nature. The antiinflammatory effect and action as immunomodulators of these secondary metabolites have been demonstrated in different studies. This review reports an overview of articles published in the last 15 years (from 2006 to 2021 using PubMed and SciFinder database) describing the antiinflammatory effects of different triterpenes with their presumed mechanism of action, suggesting that triterpenes could be appointed as natural products with future pharmaceutical applicability.

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“…Lanostane-type triterpenoids exhibited high anti-inflammatory activity by the prevention of nitric oxide release in BV-2 microglial cells. , Further chemical investigations of lanostane triterpenoids, namely, officimalonic acids, and their inhibitory activity against nitric oxide were performed in lipopolysaccharide (LPS)-induced RAW 264.7 cells . Our previous investigation of Piptoporus betulinus resulted in the discovery of several lanostane-type triterpenoids, namely, piptolinic acids, with known analogues .…”

Section: Introductionmentioning

confidence: 99%

New Triterpenoids from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity

et al. 2022

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Laetiporus sulphureus is a popular medicinal mushroom with diverse pharmacological activities in many Asian countries. Four new triterpenoids, named sulphurenoids A–D ( 1 – 4 ), along with 12 known analogues, were isolated from the fruits of L. sulphureus . Nuclear magnetic resonance, infrared spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques were used for the investigation of the chemical structure of isolated compounds. In addition, the anti-inflammatory activity of three new compounds ( 2 – 4 ) was tested for NO production in lipopolysaccharide-induced RAW 264.7 cells. The IC 50 values of isolated triterpenoids ranged from 14.3 to 42.3 μM, which were more effective than the positive control (IC 50 for minocycline was 73.0 μM). The experimentally obtained anti-inflammatory activity data of L. sulphureus are in agreement with its traditional use.

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Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in LPS-induced BV-2 cells

Cited by 10 publications

References 15 publications

Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms

Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms

Antiinflammatory activity of natural triterpenes—An overview from 2006 to 2021

New Triterpenoids from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity

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