Lanthanide upconversion and downshifting luminescence for biomolecules detection

Sun, Guotao; Xie, You; Sun, Lining; Zhang, Hongjie

doi:10.1039/d1nh00299f

Cited by 68 publications

(27 citation statements)

References 118 publications

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“…The observation of biological activities, the acquisition of biological information, and the discovery of life systems have fueled the development of biotechnologies, particularly biosensors ( Zhao et al, 2021 ). Biological signals that are difficult to perceive are converted to readable data using optics ( Sun et al, 2021a ), photothermal ( Zhou et al, 2020a ), electrochemistry ( Zhang et al, 2021b ), electrochemiluminescence ( Zhang et al, 2020 ), and other technologies. Electrochemical biosensors have thrived due to their high sensitivity, rapid response, and simplicity of operation ( Selvam et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

Li¹,

Zhang²,

Boakye³

et al. 2021

Front. Bioeng. Biotechnol.

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In the face of complex environments, considerable effort has been made to accomplish sensitive, accurate and highly-effective detection of target analytes. Given the versatility of metal clusters and ligands, high porosity and large specific surface area, metal–organic framework (MOF) provides researchers with prospective solutions for the construction of biosensing platforms. Combined with the benefits of electrochemistry method such as fast response, low cost and simple operation, the untapped applications of MOF for biosensors are worthy to be exploited. Therefore, this review briefly summarizes the preparation methods of electroactive MOF, including synthesize with electroactive ligands/metal ions, functionalization of MOF with biomolecules and modification for MOF composites. Moreover, recent biosensing applications are highlighted in terms of small biomolecules, biomacromolecules, and pathogenic cells. We conclude with a discussion of future challenges and prospects in the field. It aims to offer researchers inspiration to address the issues appropriately in further investigations.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

Li¹,

Zhang²,

Boakye³

et al. 2021

Front. Bioeng. Biotechnol.

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“…Among lanthanide ions, Sm 3+ , Eu 3+ , Gd 3+ , Tb 3+ and Dy 3+ are preferred ions for optical device implementation and optoelectronics due to their intense, long-lived and fine emissions into the visible region [12,32,80]. Additionally, Er 3+ , Ho 3+ , Yb 3+ and Tm 3+ ions are suitable ions for up-conversion emissions into visible and near-infrared regions [81,82].…”

Section: The Luminescent Properties Of 4f-5f Compoundsmentioning

confidence: 99%

Highlighting Recent Crystalline Engineering Aspects of Luminescent Coordination Polymers Based on F-Elements and Ditopic Aliphatic Ligands

2022

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Three principal factors may influence the final structure of coordination polymers (CPs): (i) the nature of the ligand, (ii) the type and coordination number of the metal center, and (iii) the reaction conditions. Further, flexible carboxylate aliphatic ligands have been widely employed as building blocks for designing and synthesizing CPs, resulting in a diverse array of materials with exciting architectures, porosities, dimensionalities, and topologies as well as an increasing number of properties and applications. These ligands show different structural features, such as torsion angles, carbon backbone number, and coordination modes, which affect the desired products and so enable the generation of polymorphs or crystalline phases. Additionally, due to their large coordination numbers, using 4f and 5f metals as coordination centers combined with aliphatic ligands increases the possibility of obtaining different crystal phases. Additionally, by varying the synthetic conditions, we may control the production of a specific solid phase by understanding the thermodynamic and kinetic factors that influence the self-assembly process. This revision highlights the relationship between the structural variety of CPs based on flexible carboxylate aliphatic ligands and f-elements (lanthanide and actinides) and their outstanding luminescent properties such as solid-state emissions, sensing, and photocatalysis. In this sense, we present a structural analysis of the CPs reported with the oxalate ligand, as the one rigid ligand of the family, and other flexible dicarboxylate linkers with –CH2– spacers. Additionally, the nature of the luminescence properties of the 4f or 5f-CPs is analyzed, and finally, we present a novel set of CPs using a glutarate-derived ligand and samarium, with the formula [2,2′-bipyH][Sm(HFG)2 (2,2′-bipy) (H2O)2]•(2,2′-bipy) (α-Sm) and [2,2′-bipyH][Sm(HFG)2 (2,2′-bipy) (H2O)2] (β-Sm).

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“…[3] In this spectral range, biosamples have very low autofluorescence [4] and thus, UC luminescence (UCL) has the potential to significantly improve the performance of bioanalytical sensors and assays. [5,6] Förster resonance energy transfer (FRET) assays have many advantages for biosensing and clinical diagnostics because they are sensitive, easy to perform, and do not require time-consuming separation or washing steps. [7][8][9][10] Energy transfer with UCNPs has been widely used for biosensing and bioimaging, [11][12][13][14][15][16][17] including the detection of deoxyribonucleic acid (DNA).…”

Section: Introductionmentioning

confidence: 99%

DNA‐Coated Upconversion Nanoparticles for Sensitive Nucleic Acid FRET Biosensing

Francés‐Soriano

Estébanez

Pérez‐Prieto

et al. 2022

Adv Funct Materials

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Despite the significant advancements of developing upconversion nanoparticles (UCNPs) for high performance biosensing and bioimaging, the development of DNA‐functionalized UCNPs with thin coatings, efficient surface passivation, and fully functional DNAs for hybridization sensing in biological media remains extremely challenging. Here, a straightforward concept of labeling DNA to a thin polysulfonate polymer layer on UCNPs is presented. Both UCNPs and DNA preserve their full functionality as demonstrated by Förster resonance energy transfer (FRET) hybridization assays with a Cy3‐conjugated complementary DNA. The important bioanalytical benefits of the UCNP‐DNA nanohybrids are demonstrated by their implementation into rapid and wash‐free microRNA hybridization FRET assays. Using a simple fiber‐coupled USB‐spectrometer and 980 nm diode laser excitation in a 96‐well microplate, ratiometric FRET from UCNP‐to‐Cy3 can quantify miR20a in a 0.01–10 × 10−9 m concentration range with a detection limit of 30 × 10−12 m (4.5 fmol of miR20a), which is more than 20‐fold lower compared to quantum dot‐based FRET assays. The functional thin‐coating DNA‐UCNP nanohybrids have a strong potential for translating UCNPs into advanced DNA‐based biosensing, bioimaging, and high‐throughput and point‐of‐care clinical diagnostics.

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Lanthanide upconversion and downshifting luminescence for biomolecules detection

Abstract: Biomolecules play critical roles in biological activities and are closely related to various disease conditions. The reliable, selective and sensitive detection of biomolecules holds much promise for specific and rapid...

Cited by 68 publications

References 118 publications

Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

Highlighting Recent Crystalline Engineering Aspects of Luminescent Coordination Polymers Based on F-Elements and Ditopic Aliphatic Ligands

DNA‐Coated Upconversion Nanoparticles for Sensitive Nucleic Acid FRET Biosensing

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