Laparoscopic cholecystectomy within one week from the onset of acute cholecystitis: A 6-year experience

Systematic review of antibiotic treatment for acute calculous cholecystitis

“…Twelve articles described randomized clinical trials (RCTs), of which four reported on two trials, and there were four prospective studies and ten retrospective studies ( Table ). Only one randomized trial compared antibiotic treatment with conservative management without antibiotics.…”

“…Only one randomized trial compared antibiotic treatment with conservative management without antibiotics. Twenty studies, including 11 RCTs and one prospective study, compared initial treatment with antibiotics and (early) cholecystectomy. Five were non‐comparative cohort studies that described the fate of patients initially treated with antibiotics.…”

“…The definition of ACC varied greatly between studies. Most studies used their own definition, which varied from clinical symptoms alone to detailed ultrasonographic findings ( Table S2 , supporting information).…”

“…Sixteen studies evaluated the need for emergency intervention after antibiotic treatment; this ranged from 0 to 44·1 per cent. The pooled event rate for the need for emergency intervention from six randomized studies was 15 (95 per cent c.i.…”

“…Fourteen studies reported recurrence of ACC following antibiotic treatment; this varied between 0 and 37 per cent. The overall pooled event rate from the eight randomized studies was 10 (95 per cent c.i.…”