Laparoscopic cytoreductive surgery and HIPEC is effective regarding peritoneum tissue paclitaxel distribution

Padilla-Valverde, David; Villarejo, Pedro; Redondo, Javier Rivera; Oyarzábal, Julen; Estella, Ángel; Palomino, Teodoro; Fernández, E. Rodríguez; Sánchez, Sergio E Ureta; Faba, Patricia; Baladrón, V.; Alberca, A; Montenegro, Omar; Fernández, Jesús Martín; Marta, Pereira; Martín, Jesús

doi:10.1007/s12094-019-02052-8

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…For mouse experiments, the following strains were used: Swiss albino (20%) [ 36 , 38 , 79 ], athymic (33%) [ 37 , 48 , 50 , 55 , 80 ], C57BL/6 (20%) [ 33 , 39 , 81 ], BALB/c (20%) [ 49 , 56 , 82 ] and NOD-SCID (7%) [ 34 ]. The following pig strains were used: white (38%) [ 58 , 60 , 61 , 83 , 84 ], sus scrofa domesticus (23%) [ 85 , 86 , 87 ], mini (8%) [ 59 ] and pigs without specifying the strain (31%) [ 88 , 89 , 90 ]. New Zealand white rabbit was the only used rabbit strain [ 41 , 42 , 91 ].…”

Section: Preclinical Hipec Modelsmentioning

confidence: 99%

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Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

Helderman

Löke

Tanis

et al. 2021

Cancers

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Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment modality for patients with peritoneal metastasis (PM) of various origins which aims for cure in combination with cytoreductive surgery (CRS). Efficacy of CRS-HIPEC depends on patient selection, tumor type, delivery technique, and treatment parameters such as temperature, carrier solution, type of drug, dosage, volume, and treatment duration. Preclinical research offers a powerful tool to investigate the impact of these parameters and to assist in designing potentially more effective treatment protocols and clinical trials. The different methodologies for peritoneal disease and HIPEC are variable. This study aims to review the objectives, methods, and clinical relevance of in vivo preclinical HIPEC studies found in the literature. In this review, recommendations are provided and possible pitfalls are discussed on the choice of type of animal and tumor model per stratified parameters and study goal. The guidelines presented in this paper can improve the clinical relevance and impact of future in vivo HIPEC experiments.

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Section: Preclinical Hipec Modelsmentioning

confidence: 99%

“…Besides the open and closed techniques, also laparoscopic HIPEC may be safe and feasible in pigs. Peritoneal drug distributions were not significantly different and less systemic uptake of paclitaxel was observed compared to the closed or open HIPEC technique [ 59 ].…”

Section: Physiological and Anticancer Aspects Of Preclinical Hipec Modelsmentioning

confidence: 99%

Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

Helderman

Löke

Tanis

et al. 2021

Cancers

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New insights in the management of pseudomyxoma peritonei

Pastier,

De Hingh,

Goéré

2024

Journal of Surgical Oncology

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While a rare entity, peritoneal pseudomyxoma treatment evolves. Decision‐making criteria improve with imaging development and exploratory laparoscopy. Surgery remains at the core of the therapeutic strategy whatever disease progression. Complete cytoreduction plus hyperthermic intraperitoneal chemotherapy (HIPEC) is standard of care. Iterative cytoreduction or debulking is sometimes justified. Intraperitoneal chemotherapy modalities change with early postoperative HIPEC or pressurized intraperitoneal aerosol chemotherapy. Systemic or local treatment such as new chemo/immuno‐therapies or BromAc should improve outcomes. Expertise and multicentric cooperation are more than ever needed.

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An Asian Tertiary Centre’s Early Experience with Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis

Linn

Seo

Wong

et al. 2022

Indian J Surg Oncol

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Laparoscopic cytoreductive surgery and HIPEC is effective regarding peritoneum tissue paclitaxel distribution

Cited by 3 publications

References 35 publications

Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

New insights in the management of pseudomyxoma peritonei

An Asian Tertiary Centre’s Early Experience with Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis

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