Laparoscopic gastric plication and its effect on saccharide and lipid metabolism: a 12-month prospective study.

Abstract

IntroductionLaparoscopic greater curvature plication (LGCP) is a novel restrictive technique that reduces gastric volume by plication of the greater curvature. The advantage of LGCP is its reversibility in comparison to laparoscopic sleeve gastrectomy. Nowadays, the long-term LGCP efficacy, safety and metabolic effect are being investigated.AimTo assess body composition, clinical complications and metabolic changes in obese patients 6 and 12 months after laparoscopic greater curvature plication.Material and methodsA total of 70 subjects underwent LGCP; 52 of them (33 women and 19 men) completed 1-year follow-up study. Anthropometry and biochemical parameters (glucose, glycated haemoglobin, lipids, ghrelin, leptin, adiponectin and fibroblast growth factor 21 [FGF-21]) were assessed before and 3, 6, and 12 months after surgery.ResultsAll study participants exhibited statistically significant weight loss at both 6 and 12 months following the LGCP compared to baseline, with significant reductions in body composition – body weight, body mass index, percentage excess weight loss (%EWL), and percentage excess BMI loss (%EBL) (p ≤ 0.001). Moreover, significant lowering of glucose and glycated haemoglobin, triacylglycerols and leptin was observed 12 months after LGCP. On the other hand, plasma concentrations of ghrelin, adiponectin and LDL cholesterol increased significantly. Total cholesterol, LDL cholesterol and FGF-21 levels did not change significantly.ConclusionsLaparoscopic greater curvature plication appears to be a procedure with good restriction results, which might be mediated through alteration in incretin metabolism. Technical aspects and standardization of the procedure still remain to be worked out.

The efficacy of selected bariatric surgery methods on lipid and glucose metabolism: a retrospective 12-month study

“…Post-operative diet is another factor that influences glucose homeostasis. These findings illustrate that, like LSG, RYGB including LGCP also has a metabolic effect, agreeing with a short-term study (13,27) reporting that 96.9% of type 2 DM patients exhibited (at the least) some improvement of their preoperative diabetic status 6 months after LGCP, with pre-and postprandial improvement of insulin sensitivity (16,28).…”

The role of bariatric surgery and appetite-related hormones metabolism in obesity treatment: a literature review

“…Our review showed that leptin level has the tendency to decrease after different types of bariatric operations [88][89][90][91].…”

Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration

“…Bužga et al investigating the long-term impact of laparoscopic greater curvature plication (LGCP) obtained similar results to the aforementioned study. They observed only a slight, but not significant, decrease in FGF-21 levels in 52 obese subjects one year after the surgery [ 75 ]. Distinct results were reported by Jansen et al who performed a study on 35 morbidly obese adults subjected to laparoscopic RYGB [ 76 ].…”

“…Journal of Diabetes Research subjects one year after the surgery [75]. Distinct results were reported by Jansen et al who performed a study on 35 morbidly obese adults subjected to laparoscopic RYGB [76].…”