Laparoscopic Magnetic Sphincter Augmentation vs Laparoscopic Nissen Fundoplication: A Matched-Pair Analysis of 100 Patients

Reynolds, Jessica L.; Zehetner, Joerg; Wu, Phil; Shah, Shawn; Bildzukewicz, Nikolai A.; Lipham, John C.

doi:10.1016/j.jamcollsurg.2015.02.025

Cited by 124 publications

(82 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, in this analysis of MSA versus LNF, we found that MSA patients had less gas bloat symptoms and increased ability to belch and vomit. Similar results were published recently from our group in a matched-pair propensity analysis of MSA versus LNF [12]. Length of stay (h ± SD) 17 ± 10 38 ± 14 \0.01 The MSA device is meant to augment a near normal LES and provide additional support during temporary failures of the LES, such as during post-prandial gastric distention or transient LES relaxation.…”

Section: Discussionsupporting

confidence: 73%

“…Despite this, insurance carriers have been hesitant to cover MSA as a surgical option for GERD, either due to concerns over perceived additional costs of the procedure or due to the lack of comparative studies to the traditional surgical treatment for GERD. Several recent comparative studies including this one have now definitively shown that MSA is equally effective as LNF in symptom control and PPI elimination rates [5,6,12]. Additionally, in this analysis of MSA versus LNF, we found that MSA patients had less gas bloat symptoms and increased ability to belch and vomit.…”

Section: Discussionsupporting

confidence: 62%

See 1 more Smart Citation

Charges, outcomes, and complications: a comparison of magnetic sphincter augmentation versus laparoscopic Nissen fundoplication for the treatment of GERD

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Discussionsupporting

confidence: 62%

Charges, outcomes, and complications: a comparison of magnetic sphincter augmentation versus laparoscopic Nissen fundoplication for the treatment of GERD

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Louie et al [23] performed a retrospective case–control study comparing 66 patients undergoing LINX or Nissen fundoplication; at a mean follow-up of 6 and 10 months, respectively, scores on the GERD-HRQL scale significantly improved in both groups. Reynolds et al [24] conducted a retrospective analysis of 1-year outcomes of 100 patients matched by PS; although the GERD-HRQL scores were similar in both groups, there were 10.6% of patients in the Nissen group complaining of severe gas-bloat symptoms compared with 0% in the LINX group. Finally, a smaller case-matched study by Sheu et al [25] including 24 patients followed for an average of 7 months showed that severe dysphagia requiring endoscopic dilation was more frequent in the LINX group.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal comparison of quality of life in patients undergoing laparoscopic Toupet fundoplication versus magnetic sphincter augmentation

et al. 2016

View full text Add to dashboard Cite

Only a minority of patients with gastro-esophageal reflux disease (GERD) are offered a surgical option. This is mostly due to the fear of potential side effects, the variable success rate, and the extreme alteration of gastric anatomy with the current gold standard, the laparoscopic Nissen fundoplication. It has been reported that laparoscopic Toupet fundoplication (LTF) and laparoscopic sphincter augmentation using a magnetic device (LINX) can treat reflux more physiologically and with a lower incidence of side-effects and reoperation rate. We present the first comparing quality of life in patients undergoing LTF versus LINX.Observational cohort study. Consecutive patients undergoing LTF or LINX over the same time period were compared by using the propensity score full matching method and generalized estimating equation. Criteria of exclusion were >3 cm hiatal hernia, grade C–D esophagitis, ineffective esophageal motility, body mass index >35, and previous upper abdominal surgery. The primary study outcome was quality of life measured with the Gastro-Esophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) questionnaire. Secondary outcomes were proton pump inhibitors (PPI) use, presence of gas-related symptoms or dysphagia, and reoperation-free probability.Between March 2007 and July 2014, 238 patients with GERD met the criteria of inclusion in the study. Of these, 103 underwent an LTF and 135 a LINX procedure. All patients had a minimum 1-year follow-up. Over time, patients in both groups had similar GERD-HRQL scores (odds ratio [OR] 1.04, confidence interval [CI] 0.89–1.27; P = 0.578), PPI use (OR 1.18, CI 0.81–1.70; P = 0.388), gas-related symptoms (OR 0.69, CI 0.21–2.28; P = 0.542), dysphagia (OR 0.62, CI 0.26–1.30; P = 0.241), and reoperation-free probability (stratified log-rank test = 0.556).In 2 concurrent cohorts of patients with early stage GERD undergoing LTF or LINX and matched by propensity score analysis, health-related quality of life significantly improved and GERD-HRQL scores had a similar decreasing trend over time up to 7 years of follow-up. We conclude that LTF and LINX provide similar disease-specific quality of life over time in patients with early stage GERD.

show abstract

“…Of 14 clinical trials that initially met the inclusion criteria, 8 did not display the specific comparison of the effects of MSA and NF, 1 [20] was reported by one author from the same center, and 1 [21] did not provide enough original data. Finally, 4 [22–25] retrospective studies matched the selection criteria and were published between 2005 and September 2016 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Magnetic Sphincter Augmentation versus Nissen Fundoplication for Gastroesophageal Reflux Disease in Short Term: A Meta-Analysis

Chen

Huang

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

Background. The efficacy of Magnetic Sphincter Augmentation (MSA) and its outcomes for Gastroesophageal Reflux Disease (GERD) are uncertain. Therefore, we aimed to summarize and analyze the efficacy of two treatments for GERD. Methods. The meta-analysis search was performed, using four databases. All studies from 2005 to 2016 were included. Pooled effect was calculated using either the fixed or random effects model. Results. A total of 4 trials included 624 patients and aimed to evaluate the differences in proton-pump inhibitor use, complications, and adverse events. MSA had a shorter operative time (MSA and NF: RR = −18.80, 95% CI: −24.57 to −13.04, and P = 0.001) and length of stay (RR = −14.21, 95% CI: −24.18 to −4.23, and P = 0.005). Similar proton-pump inhibitor use, complication (P = 0.19), and severe dysphagia for dilation were shown in both groups. Although there is no difference between the MSA and NF in the number of adverse events, the incidence of postoperative gas or bloating (RR = 0.71, 95% CI: 0.54–0.94, and P = 0.02) showed significantly different results. However, there is no significant difference in ability to belch and ability to vomit. Conclusions. MSA can be recommended as an alternative treatment for GERD according to their short-term studies, especially in main-features of gas-bloating, due to shorter operative time and less complication of gas or bloating.

show abstract

Laparoscopic Magnetic Sphincter Augmentation vs Laparoscopic Nissen Fundoplication: A Matched-Pair Analysis of 100 Patients

Cited by 124 publications

References 15 publications

Charges, outcomes, and complications: a comparison of magnetic sphincter augmentation versus laparoscopic Nissen fundoplication for the treatment of GERD

Charges, outcomes, and complications: a comparison of magnetic sphincter augmentation versus laparoscopic Nissen fundoplication for the treatment of GERD

Longitudinal comparison of quality of life in patients undergoing laparoscopic Toupet fundoplication versus magnetic sphincter augmentation

Efficacy of Magnetic Sphincter Augmentation versus Nissen Fundoplication for Gastroesophageal Reflux Disease in Short Term: A Meta-Analysis

Contact Info

Product

Resources

About