Laparoscopic proctocolectomy with ileal j-pouch anal anastomosis in children

Ateş, Ufuk; Ergün, Ergun; Göllü, Gülnur; Küçük, Gönül; Yağmurlu, Aydın

doi:10.5152/tjg.2017.16695

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…In this review, the percentage of fistula in pediatric patients who underwent J-pouch with ileostomy was low (at 2%). This aligns with previous literature indicating low prevalence of fistula in children with familial adenomatous polyposis (FAP) and UC postoperation for J-pouch 66 67…”

Section: Discussionsupporting

confidence: 92%

Postoperative complications of colectomy and J-pouch with ileostomy versus without ileostomy in children with inflammatory bowel diseases: a systematic review and meta-analysis

Oltean

Travis

Kaur

et al. 2022

World Jnl Ped Surgery

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BackgroundThe efficacy of performing a restorative proctocolectomy and J-pouch ileoanal anastomosis without diverting ileostomy in children with inflammatory bowel disease has been a longstanding debate. A systematic review and meta-analysis is presented comparing the occurrence of postoperative complications in children who underwent either the pouch-anal anastomosis (IPAA) with ileostomy (diverted) versus the undiverted procedure.MethodsRecords were sourced from CINAHL, CENTRAL, EMBASE and MEDLINE databases. Studies followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and compared postoperative complications in pediatric patients diagnosed with inflammatory diseases aged less than 18 years who underwent J-pouch with ileostomy versus without ileostomy. The primary outcome was the occurrence of postoperative leaks, and the secondary outcomes were presence of postoperative small bowel obstruction (SBO), pouchitis, stricture and fistula complications. A random-effects meta-analysis was used.ResultsTwenty-three observational studies in the systematic review were included with 658 patients (83% diverted, 17% undiverted). Pooled estimates showed no difference in occurrence of leaks in children who underwent J-pouch/IPAA with ileostomy versus without (odds ratio (OR) 0.54, 95% confidence interval (CI) 0.17 to 1.64, I2=16%). There was no difference in the occurrence of SBO, pouchitis or strictures in children who underwent J-pouch/IPAA with ileostomy versus without (SBO: OR 2.27, 95% CI 0.52 to 9.92, I2=0%, pouchitis: OR 1.76, 95% CI 0.95 to 3.24, I2=0%, strictures: OR 2.72, 95% CI 0.44 to 16.69, I2=66%).ConclusionThe meta-analysis did not find differences in the occurrence of complications in pediatric patients who underwent the IPAA with ileostomy procedure versus without ileostomy.

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Section: Discussionsupporting

confidence: 92%

Postoperative complications of colectomy and J-pouch with ileostomy versus without ileostomy in children with inflammatory bowel diseases: a systematic review and meta-analysis

Oltean

Travis

Kaur

et al. 2022

World Jnl Ped Surgery

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“…The increased Bax/Bcl‐2 ratio promoted apoptosis, while decreased Bax/Bcl‐2 ratio inhibited apoptosis. [ 27–29 ] Our study is consistent with the finding that DATS increased the Bax/Bcl‐2 ratio. Accordingly, we assessed the effect of Bcl‐2 on the apoptosis of HSCs.…”

Section: Discussionsupporting

confidence: 91%

Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl‐2 in hepatic stellate cells

Pang

Wang

et al. 2022

J Biochem & Molecular Tox

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Hepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date. Hepatic stellate cells (HSCs) are the main cells involved in the formation of hepatic fibrosis, and induction of the apoptosis of HSCs is an important strategy for the treatment of hepatic fibrosis. Diallyl trisulfide (DATS) is a natural product and is the main active ingredient in garlic. However, the exact molecular mechanisms underlying HSC apoptosis induced by DATS are not well understood. This study aimed to analyze the efficiency and mechanism of DATS in hepatic fibrosis. Different concentrations (25, 50, 100, and 200 μM) of DATS were used to treat HSCs. Changes in cell morphology and formation of apoptotic bodies were observed under an inverted microscope and an electric microscope. Bcl‐2 signaling involving Bax, Caspase‐3, Caspase‐6, Caspase‐8, Caspase‐9, p53, Apaf‐1, and Cyto‐c in fibrosis were examined, which is a critical step in the evaluation of antihepatic fibrosis agents. We also evaluated the effect of DATS on the cellular morphology of HSCs and apoptosis‐related factors under different Bcl‐2 expression states. Our results suggest that DATS regulates hepatic fibrosis by blocking the Bcl‐2 signaling pathway and upregulating the Bax/Bcl‐2 ratio.

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Colon polyps in children

et al. 2022

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Aim: to evaluate the results of bowel polyposis in children. Patients and methods: the retrospective study included children, aged 1 to 17 years. The clinic manifestations, diagnostics and treatment approach are described. Patients with adenomatous polyposis (n = 38) and juvenile polyposis (n = 16) are presented in details. Results: options for surgical procedure are described due to early and late results, morphological data and diagnostic findings (colectomy with ileorectal anastomosis and formation of seromuscular cylinder, n = 8; colproctectomy with ileal pouch, n = 10). Conclusions: the detection of colorectal polyps requires a wide range of diagnostic and treatment approaches depends on a clear understanding of the nosological form of polyposis, which allows to determine the optimal period and method of surgical treatment.

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Laparoscopic proctocolectomy with ileal j-pouch anal anastomosis in children

Cited by 3 publications

References 11 publications

Postoperative complications of colectomy and J-pouch with ileostomy versus without ileostomy in children with inflammatory bowel diseases: a systematic review and meta-analysis

Postoperative complications of colectomy and J-pouch with ileostomy versus without ileostomy in children with inflammatory bowel diseases: a systematic review and meta-analysis

Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl‐2 in hepatic stellate cells

Colon polyps in children

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