Purpose: Laparoscopic total extraperitoneal repair (TEP) is one of the most preferred minimally invasive methods for inguinal hernia repair. In our study, we aimed to compare the advantages and disadvantages of general anesthesia (GA), spinal anesthesia (SA), and epidural anesthesia (EA) for TEP operations.Materials and Methods: This is a retrospective study involving 221 patients who underwent TEP surgery for inguinal hernia between January 2018 and July 2020. Patients were divided into 3 groups as GA (n = 77), SA (n = 70), and EA (n = 74). Demographic data of the patients, duration of anesthesia and surgery, perioperative and postoperative complications, postoperative pain, anatomical delineation, hospital stay and quality of life were evaluated.Results: Anesthesia time was the longest in the EA group (23.1 ± 2.32 min) and significantly prolonged the operation time (P < 0.001). When the visual analog scale scores were compared, it was observed that the patients in the GA group felt significantly more pain (P < 0.001). While the rates of hypotension and headache were higher in regional anesthesia (P < 0.001 and P < 0.002), there was no significant difference in urinary retention, postoperative nausea/vomiting, and shoulder pain (P = 0.274, 0.262, and 0.314, respectively). SA and EA groups were found to be superior compared with the GA group in terms of patient satisfaction (P < 0.001). Conclusion: Regional anesthesia (SA and EA) can be safely performed in TEP surgeries, gives results similar to the anatomical delineation satisfactory and complication rates of GA, and results in less postoperative pain.