Laparoscopy versus laparotomy in endometrial cancer: First analysis of survival of a randomized prospective study

Tozzi, Roberto; Malur, Sabine; Koehler, Christhardt; Schneider, Achim

doi:10.1016/j.jmig.2005.01.021

Cited by 221 publications

(136 citation statements)

References 34 publications

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“…In our study no significant difference was found between groups. This finding is similar to the majority of the published studies [12][13][14][15][16][17]. In Zullo et al [9] metaanalysis the mean number of nodes obtained ranged from 8.86 to 23.5.…”

Section: Discussionsupporting

confidence: 88%

“…This way we found no statistical difference in OS. Most of the RCTs [12,16,17] show the same results, although there are not many studies that evaluate survival and even less for a long period (Tozzi [16] 44 months, Zullo [17] 79 months, Malzoni [12] 38.5 months). Older studies neither show differences in OS: Malur [19] found no differences studyingin 57 patients, Pignotti [20] with a 45 months follow-up obtained 5.3% recurrences in the LPS group and 7.4% in the LPT group.…”

Section: Discussionmentioning

confidence: 90%

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Laparoscopic versus laparotomy approach to endometrial cancer: A prospective study

Carlos¹,

Martín-Francisco²,

Ángel³

et al. 2013

OJOG

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Objective: The aim of this study was to compare laparoscopic (LPS) and laparotomy (LPT) approaches for endometrial cancer, and to assess intraoperative and postoperative results, disease-free survival and overall survival. Methods: We designed a prospective observational study, every patient diagnosed of endometrial cancer and subsidiary to surgical staging was included. Total hysterectomy, bilateral adnexectomy, pelvic lymphadenectomy were performed in every case. Paraaortic lymphadenectomy was performed depending on tumor histology. Results: 70 patients with endometrial cancer were enrolled, 49 (70%) were treated laparoscopically and 21 (30%) laparotomically. There was not statistical significant difference in the mean operative time, it was 183.06 ± 21.03 min (range 120 -230) in the LPS group and 195.24 ± 28.39 min (range 130 -240) in the LPT group, mean difference 12.16 (95% CI −0.2 -24). There was no difference in the number of lymph nodes resected. Mean blood loss was lower in the LPS group. There were less postoperative complications, 3 (6.12%) in the LPS group and 7 (33.3%) in the LPT group (p < 0.01). Mean hospital stay was significantly shorter in the LPS group 4.29 ± 1.62 days vs 8.81 ± 3.37 days in the LPT group (p < 0.01), mean difference 4.52 (95% CI 3.3 -5.7). Overall survival was similar in both groups. Conclusion: Laparoscopic approach for endometrial cancer offers similar results in terms of survival and oncological radicality as the laparotomic approach and a lower rate of complications, a quicker convalescence time and a shorter hospital stay.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 90%

Laparoscopic versus laparotomy approach to endometrial cancer: A prospective study

Carlos¹,

Martín-Francisco²,

Ángel³

et al. 2013

OJOG

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“…By contrast, most studies evaluating minimally invasive treatments for endometrial cancer are small, retrospective studies comparing laparotomy to either RALS or CLS [7][8][9]11,12,[32][33][34][35]. Our group has previously reported on similar outcomes when comparing RALS with CLS in other types of gynecologic cancer [20,21].…”

Section: Journal Of Adenocarcinoma Issn 2572-309xmentioning

confidence: 85%

Perioperative Outcomes in Robotic-Assisted Versus Conventional Laparoscopic Treatment of Endometrial Cancer

Nezhat¹,

Apostol²,

Vega³

et al. 2016

J Adenocarcinoma

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“…Otro factor importante es la cantidad de ganglios resecados por vía laparoscópica, la cual oscila entre 14 y 18, similar a lo resecado por vía abdominal (16,21,22,24,(43)(44)(45) (Tabla III). Aparentemente la linfadenectomía laparoscópica con ultrasonido lograría un número mayor de ganglios (14 vs 18) y estos serían más fáciles de interpretar por el patólogo (46).…”

Section: Tabla II Recurrencia En Pacientes Con Cáncer De Endometrio Eunclassified

Abordaje Laparoscópico en Cáncer De Endometrio

Nüñez

S²,

et al. 2009

Rev. chil. obstet. ginecol.

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RESUMENEl cáncer de endometrio es una neoplasia ginecológica relevante en todo el mundo, con cambios acelerados en su manejo. La cirugía es el tratamiento de elección, pero puede llegar a tener una alta tasa de complicaciones y retraso en el inicio de terapias adyuvantes por el trauma quirúrgico que provoca. Este artículo revisa el rol de la laparoscopia en el manejo de las pacientes con cáncer endometrial, haciendo hincapié en su seguridad oncológica, beneficios y complicaciones. Al comparar la vía clásica por laparotomía, la laparoscopia, en manos experimentadas, tiene similares resultados respecto de sobrevida, recurrencia y etapificación completa, pero con una menor tasa de complicaciones. La vía endoscópica podría ser la herramienta del futuro en el manejo del cáncer de endometrio PALABRAS CLAVE: Cáncer de endometrio, linfadenectomía, laparoscopia, laparotomía SUMMARY Endometrial cancer is a relevant gynecologic neoplasm, with accelerated changes in its management. Surgery is the treatment of choice, but it can have a high rate of complications and delay in adjuvant therapies due to the surgical trauma that it inflicts. This article reviews the role of laparoscopy in the management of women with endometrial cancer, highlighting the oncologic safety, benefits and complications. Comparing laparotomy with laparoscopy, in experienced hands, it has the same results concerning to survival, recurrence and complete staging, with a lower rate of complications. Celioscopy could be the tool of the future in the management of endometrial cancer KEY WORDS: Endometrial cancer, lymphadenectomy, laparoscopy, laparotomy INTRODUCCIÓNEl cáncer de endometrio es la cuarta patología neoplásica más frecuente en la mujer y la primera del tracto genital femenino, con 39.080 casos nuevos por año (6% de todos los cánceres femeninos) y 7.400 nuevas muertes por año (3% de las muertes por cáncer en mujeres) en EEUU y una prevalencia estable en los últimos 15 años, estimándose que 1 de cada 40 mujeres desarrollará en algún momento de su vida cáncer de endometrio (1). Afortunadamente el 71% de estos cánceres son pesquisados en etapa precoz (2), lo que permitiría tomar medidas terapéuticas efectivas que aumenten la sobrevida,

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Laparoscopy versus laparotomy in endometrial cancer: First analysis of survival of a randomized prospective study

Cited by 221 publications

References 34 publications

Laparoscopic versus laparotomy approach to endometrial cancer: A prospective study

Laparoscopic versus laparotomy approach to endometrial cancer: A prospective study

Perioperative Outcomes in Robotic-Assisted Versus Conventional Laparoscopic Treatment of Endometrial Cancer

Abordaje Laparoscópico en Cáncer De Endometrio

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