Large and small medial frontal cortex lesions and spatial performance of the rat

Wolf, Cynthia; Waksman, Daniel; Finger, Stanley; Cr, Almli

doi:10.1016/0361-9230(87)90025-6

Cited by 33 publications

(17 citation statements)

References 22 publications

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Section: Discussionmentioning

confidence: 99%

“…Of particular interest is the body of work in rodents involving reversal with a spatial component (Li & Shao, 1998;Wolf et al, 1987). Wolf et al (1987) found that lesions of the medial prefrontal cortex (mPFC) in rats selectively impaired reversal of a position habit, but not acquisition. Li and Shao (1998) lesioned different parts of the mPFC in rats and found that the prelimbic area and the infralimbic area affected reversal learning, but not original discrimination learning.…”

Section: Discussionmentioning

confidence: 99%

“…Frontal cortical functioning is implicated in reversal in many species, including rats (Chudasama & Robbins, 2003;Cools, Clark, Owen, & Robbins, 2002;Divac, 1971;Joel, Weiner, & Feldon, 1997;Li & Shao, 1998;Mihalick, Crandall, Langlois, Krienke, & Dube, 2001;Passingham, 1972;Wolf, Waksman, Finger, & Almli, 1987), primates (Passingham, 1972;Pohl, 1973), and humans (Cools et al, 2002). Hippocampal functioning also has been shown to play a role in discrimination reversal (McDonald, Ko, & Hong, 2002;Winocur & Olds, 1978).…”

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confidence: 96%

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Contextual modulation of spatial discrimination reversal in developing rats

2004

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Reversal of discrimination learning is influenced by manipulation of the training context. In adult and developing rats, contextual changes made between acquisition and reversal aid the learning of the new discrimination, possibly by serving to release proactive interference from the originally acquired discrimination (M. E. Bouton & D. C. Brooks, 1993; N. Spear, G. Smith, R. Bryan, & W. Gordon, 1980). The present study sought to examine this effect in an appetitive T-maze task, as a function of different contextual manipulations. Rats of three ages, Postnatal Day (PND) 19, PND23, and PND30, were tested for their ability to acquire and reverse a position habit in a T-maze. Contextual changes were made between acquisition and reversal sessions and consisted of one of three manipulations: (a) texture; the texture of the maze floor was changed via the addition or subtraction of wire mesh; (b) maze; subjects were reversed in a different maze that was identical in construction to the training maze, but differed in spatial location; (c) texture and maze; subjects were shifted to the new maze, the floor of which differed in texture from the training maze but was otherwise identical in construction. Results showed that the texture-maze combination was an effective aid to reversal learning at all ages tested. The texture alone, however, was not effective at any age. The maze alone also was an effective cue for reversal, but proved to have the greatest effect for PND30 subjects. During ontogeny, the contextual modulation of reversal learning is importantly influenced by the nature and the salience of the contextual cue.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

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Contextual modulation of spatial discrimination reversal in developing rats

2004

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“…As the hippocampus is preferentially engaged during task acquisition, SS-13 BN animals exhibit improved acquisition compared to the SS strain. Cognitive flexibility is believed to primarily involve the prefrontal cortex (PFC) (Chudasama and Robbins 2003;Passetti et al 2002;Wolf et al 1987), which is not necessary for task acquisition (Lacroix et al 2002). Therefore, the partial rescue observed in the current study may be the result of regional differences in the impact of 13 BN introgression on neural function.…”

Section: Discussionmentioning

confidence: 82%

Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat

et al. 2009

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The present study was conducted in an effort to evaluate whether chromosomal substitution can repair impaired exploration learning and memory. It has previously been observed that Dahl salt-sensitive (SS) rodents exhibit impaired cognitive function along with abnormal physiological responses to muscle stimulation. Introgression of Brown Norway chromosome (13(BN)) has been found to restore normal physiological processes in SS animals. However, the effect of chromosomal substitution on cognitive performance has not been explored. It was hypothesized that 13(BN) also rescues cognitive impairments in these animals. Visual spatial learning and cognitive flexibility were evaluated using the Morris water maze (MWM) and the T-maze. This manipulation is effective in rescuing impaired task acquisition, but not perseveration observed in the SS animal. These animals may represent a natural animal model in which to isolate genetic information responsible for learning and memory function.

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“…Nevertheless, the needle was inserted by hand and not stereotactically, and this probably added to the variability. There are several experimental techniques available to produce lesions in the cortex, such as aspiration through glass pipettes 14,15,35 or electrolysis by using Teflon-coated electrodes. 13 The aspiration/ablation technique also creates a rather variable lesion.…”

Section: Methodological Problemsmentioning

confidence: 99%