Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring

Tian, Limei; Zimmerman, Benjamin; Akhtar, Aadeel; Yu, Ki Jun; Moore, Matthew; Wu, Jian; Larsen, Ryan J.; Lee, Jung Woo; Wang, Kun; Metzger, Brian; Qu, Subing; Guo, Xiaogang; Mathewson, Kyle E.; Fan, Jonathan A.; Cornman, Jesse; Fatina, Michael; Xie, Zhaoqian; Ma, Yinji; Zhang, Jue; Zhang, Yihui; Dolcos, Florin; Fabiani, Monica; Gratton, Gabriele; Bretl, Timothy; Hargrove, Levi J.; Braun, Paul V.; Huang, Yonggang; Li, Jinghua

doi:10.1038/s41551-019-0347-x

Cited by 300 publications

(310 citation statements)

References 47 publications

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“…However, there is still lack of safety evaluations and detailed chronic studies of the organs as a result of device penetrations. Other safety challenges of implantable electronics include MRI and X‐ray incompatibility249–251 and electrical current leakages 2. Moreover, novel materials used for biomedical tools and biomedicine need further verification by federal regulators in terms of their safety 252,253.…”

Section: Resultsmentioning

confidence: 99%

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

et al. 2020

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The rapid pace of progress in implantable electronics driven by novel technology has created devices with unconventional designs and features to reduce invasiveness and establish new sensing and stimulating techniques. Among the designs, injectable forms of biomedical electronics are explored for accurate and safe targeting of deep‐seated body organs. Here, the classes of biomedical electronics and tools that have high aspect ratio structures designed to be injected or inserted into internal organs for minimally invasive monitoring and therapy are reviewed. Compared with devices in bulky or planar formats, the long shaft‐like forms of implantable devices are easily placed in the organs with minimized outward protrusions via injection or insertion processes. Adding flexibility to the devices also enables effortless insertions through complex biological cavities, such as the cochlea, and enhances chronic reliability by complying with natural body movements, such as the heartbeat. Diverse types of such injectable implants developed for different organs are reviewed and the electronic, optoelectronic, piezoelectric, and microfluidic devices that enable stimulations and measurements of site‐specific regions in the body are discussed. Noninvasive penetration strategies to deliver the miniscule devices are also considered. Finally, the challenges and future directions associated with deep body biomedical electronics are explained.

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Section: Resultsmentioning

confidence: 99%

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

et al. 2020

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“…神经接口可以作为损失的神经系统功能的人工延伸 [90] , 能够记录和刺激神经活动, 将外部假肢与内部神经联系起来, 有机材料、导电聚合物和复合材料都是神经接口应用的重要材料. Tian等人 [91] 研发了一种大面积的表皮电子生理传感器, 可大面积覆盖, 他们将该电生理设备成功地覆盖在整个头皮和小臂的位置, 并演示了用这样的电子接口多功能地控制患者的假肢.…”

Section: 假肢和人体神经系统充分接触并且相互作用才能unclassified

Recent research progress in biomimetic tactile sensors

Zhang¹,

Ma²,

Li³

et al. 2019

Sci. Sin.-Tech.

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Section: Introductionmentioning

confidence: 99%

Bio‐Multifunctional Smart Wearable Sensors for Medical Devices

Wang

Lou

Jiang

et al. 2019

Advanced Intelligent Systems

139

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Advances in digital health care have driven innovations in high‐performance wearable and smart sensors. One requirement in this field is establishing healthy, secure, and reliable medical devices for precisely monitoring vital signs of the human body or the surrounding environment through flexible sensors with not only high‐sensing performance but also excellent biofunctionality. Smart wearable sensors with excellent biofunctionality furnish medical devices with various smart functions such as biocompatibility, biodegradability, and self‐healing, which have attracted widespread interest from device engineers and materials scientists. Herein, a comprehensive review of the latest progress concerning these smart wearable sensors is presented with a focus on bio‐multifunctional (biocompatible, biodegradable, and self‐healing) device designs. The medical applications of bio‐multifunctional smart wearable sensors are also briefly covered, and to conclude, a discussion of the challenges, opportunities, and future perspectives is provided.

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Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring

Cited by 300 publications

References 47 publications

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

Recent research progress in biomimetic tactile sensors

Bio‐Multifunctional Smart Wearable Sensors for Medical Devices

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