Large Bowel Obstruction Caused by Metastatic Prostate Cancer: A Case Report

Abstract

Bowel obstruction is a frequently encountered condition worldwide that causes numerous admissions to hospitals. Metastatic carcinoma has been identified as one of the infrequently encountered causes of bowel obstruction. Prostate cancer typically metastasizes to lymph nodes, bone, lungs, liver, and brain. In this article, we reported the case of a 75-year-old man who presented with bowel obstruction due to narrowing and stricture of the rectum. Primary rectal mass was initially diagnosed, but upon further investigation, it was found that the mass resembled prostate tissue. The bowel obstruction was managed surgically with a colostomy. The patient was later referred to oncology for chemotherapy and hormonal therapy.

Rectal Tropism: An Extremely Rare Case of Prostate Cancer Recurrence With Metastasis to the Rectum Postradical Prostatectomy

“…4 It affects about 1 in 8 men during their lifetime. 3 Risk factors include advanced age, African American ethnicity, and a family history of prostate cancer. 3,4 Prostate cancer arises from mutations in the prostate gland cells, mainly in the p53 gene or Akt kinase signaling alterations.…”

“…5 The anatomical structure of the prostate gland and its relationship with the rectal wall provide 3 possible routes for prostate cancer to infiltrate the colorectal tissue. 3,4,6 Prostate cancer can infiltrate the colorectal tissue by infiltrating Denonvilliers' fascia. 3,6 Pelvic lymph nodes also receive drainage from the prostate gland and the rectum, which provides another possible mechanism of cancer spread.…”

“…3 Seeding of cancer cells into the perirectal or rectal tissue during prostate biopsy is the third route. 3 Prostatic cancer spread to the rectum often presents as diarrhea, rectal bleeding, pruritus, or obstruction. [3][4][5][6] Almujarkesh et al 3 reported a unique case of large bowel obstruction due to metastatic prostate cancer.…”

“…3 Risk factors include advanced age, African American ethnicity, and a family history of prostate cancer. 3,4 Prostate cancer arises from mutations in the prostate gland cells, mainly in the p53 gene or Akt kinase signaling alterations. 5 While the progression of prostate cancer is generally predictable, there are instances where the diagnosis proves difficult.…”

“…1 This neoplasm commonly spreads to the regional lymph nodes, liver, lungs, and bones. 2,3 Rectal tropism of metastasis is extremely rare and poses a diagnostic challenge. 1,2,4 The proposed pathophysiology is via lymphatic spread, seeding during a transrectal biopsy, or local tissue invasion.…”