Large, Non-Cavity Distorting Intramural Leiomyomas Decrease Leukemia Inhibitory Factor in the Secretory Phase Endometrium

Pier, Bruce; Crellin, Christopher; Katre, Ashwini A.; Conner, Michael; Novak, Lea; Young, Steven L.; Arend, Rebecca C.

doi:10.1007/s43032-019-00056-x

Cited by 14 publications

(13 citation statements)

References 45 publications

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“…In several human studies, the LIF levels were shown to be upregulated in the luteal phase and reach their highest expression levels during WOI; in contrast, women with submucosal UFs show decreased levels of LIF during the luteal phase. Additionally, a recent study demonstrated that LIF is significantly downregulated in the endometrium of women with large (≥3 cm) and non-cavity-distorting intramural UFs ( Pier et al, 2020 ). Once the embryo has attached to the endometrium, IL-11 moderates trophoblast invasion.…”

Section: Resultsmentioning

confidence: 99%

Understanding the Impact of Uterine Fibroids on Human Endometrium Function

Navarro

Bariani

Yang

et al. 2021

Front. Cell Dev. Biol.

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Uterine fibroids (leiomyomas) are the most common benign gynecological tumors in women of reproductive age worldwide. They cause heavy menstrual bleeding, usually leading to severe anemia, pelvic pain/pressure, infertility, and other debilitating morbidities. Fibroids are believed to be monoclonal tumors arising from the myometrium, and recent studies have demonstrated that fibroids actively influence the endometrium globally. Studies suggest a direct relationship between the number of fibroids removed and fertility problems. In this review, our objective was to provide a complete overview of the origin of uterine fibroids and the molecular pathways and processes implicated in their development and growth, which can directly affect the function of a healthy endometrium. One of the most common characteristics of fibroids is the excessive production of extracellular matrix (ECM) components, which contributes to the stiffness and expansion of fibroids. ECM may serve as a reservoir of profibrotic growth factors such as the transforming growth factor β (TGF-β) and a modulator of their availability and actions. Fibroids also elicit mechanotransduction changes that result in decreased uterine wall contractility and increased myometrium rigidity, which affect normal biological uterine functions such as menstrual bleeding, receptivity, and implantation. Changes in the microRNA (miRNA) expression in fibroids and myometrial cells appear to modulate the TGF-β pathways and the expression of regulators of ECM production. Taken together, these findings demonstrate an interaction among the ECM components, TGF-β family signaling, miRNAs, and the endometrial vascular system. Targeting these components will be fundamental to developing novel pharmacotherapies that not only treat uterine fibroids but also restore normal endometrial function.

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Section: Resultsmentioning

confidence: 99%

Understanding the Impact of Uterine Fibroids on Human Endometrium Function

Navarro

Bariani

Yang

et al. 2021

Front. Cell Dev. Biol.

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“…A recent study hypothesized that large intramural leiomyomas decrease the expression of endometrial implantation factors during the implantation window ( 15 ). Other authors confirm that genetic favoring of endometrial receptivity increases after intramural myomectomy, even when they do not distort the cavity ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Twisted Uterus Caused by Endometriosis or Myomatosis on Reproductive Treatment Outcomes

Moliner

Sellers

Bernabéu

et al. 2021

JFRH

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Objective: Twisted uterus is detected when the body of the uterus is rotated from the cervical canal. This anomaly may be due to different causes, such as uterine fibroids, endometriosis or the presence of both. The study has aimed to compare the effect of the twisted uterus cause in terms of reproductive treatment outcomes. Materials and methods: It consisted of a retrospective study of twisted uterus cases with repeated implantation failure (more than three embryo transfers or four blastocysts transferred unsuccessfully) in our ultrasound department. The twisted uterus was defined when the vaginal probe needed to be rotated to assess the endometrial line thoroughly or when the coronal view was seen by 2D scan. From 2017 to 2020, 879 gynecological ultrasounds were performed. For statistical analysis, we carried out a logistical regression analysis adjusted by confounding factors. Results: From 145 patients included only 92 patients underwent reproductive treatments. With the known cause of uterine torsion. 56 patients with endometriosis, 18 with uterine myoma and the remaining 18 suffered from both. After assisted reproductive treatment, the endometriosis group showed the highest clinical pregnancy rate (53.57%) compared to myoma (22.22%) and endometriosis and myoma (38.89%) groups. Conclusion: Uterine myoma capable of causing uterine torsion may affect embryo implantation more than endometriosis. Prospective randomized studies with a larger number of patients would be needed to confirm these findings.

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“…RIF may be attributed to anatomical disorders that distort the endometrial cavity, being undiagnosed before IVF treatment. In that context, fibroids have been reported as negative prognosticators to IVF success ( Wang et al, 2018 ; Rikhraj et al, 2020 ), altering endometrial receptivity by modifying HOXA10 and LIF expression ( Makker et al, 2017 ; Kara et al, 2019 ; Pier et al, 2020 ). Endometrial adhesions as a result of infection or prior surgical procedure may also be considered to be associated with thin endometrium and low receptivity potential ( Wang et al, 2020 ).…”

Section: The Endometrial Pathophysiology Of Rifmentioning

confidence: 99%

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

Makrigiannakis

Makrygiannakis

Vrekoussis

2021

Front. Cell Dev. Biol.

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Repeated implantation failures are a constant challenge in reproductive medicine with a significant impact both on health providers and on infertile couples. Several approaches have been proposed so far as effective; however, accumulative data have clarified that most of the treatment options do not have the evidence base for a generalized application to be suggested by the relevant societies. Implantation failures are attributed to either poor quality embryos or to defected endometrial receptivity. The current review aims to summarize in a systematic way all the new trends in managing RIF via interference with endometrial receptivity. The authors focus mainly, but not exclusively, on endometrial injury prior to embryo transfer and endometrial priming with autologous cells or biological agents. To this direction, a systematic search of the Pubmed database has been conducted taking into account the emerged evidence of the last two decades. All the suggested interventions are herein presented and analyzed in terms of reproductive outcomes. It is evident that properly powered and designed randomized trials are needed to support a new standard approach in RIF treatment that will safely be incorporated in national and international guidelines.

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Large, Non-Cavity Distorting Intramural Leiomyomas Decrease Leukemia Inhibitory Factor in the Secretory Phase Endometrium

Cited by 14 publications

References 45 publications

Understanding the Impact of Uterine Fibroids on Human Endometrium Function

Understanding the Impact of Uterine Fibroids on Human Endometrium Function

The Effect of Twisted Uterus Caused by Endometriosis or Myomatosis on Reproductive Treatment Outcomes

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

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