Large Retroperitoneal Liposarcoma – A Series of Five Cases

Joshi, Rajeev; Gangurde, Gautum K.; Talathi, Nikhil P.; Telavane, Parag P.; Singh, Rajinder; Hanamshetti, Satish R.; Adhikari, Devbrata

doi:10.1007/s12262-011-0348-9

Cited by 9 publications

(12 citation statements)

References 21 publications

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“…Large retroperitoneal liposarcomas present unique challenges and require more aggressive surgical approach that may include multiple resections for recurrences (35). Multiple re-operations for recurrent disease may result in significant increase in longterm survival, even despite the overall higher rate of local recurrence of PRPLS compared to other sarcomas (36).…”

Section: Discussionmentioning

confidence: 99%

Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma

et al. 2021

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Background: Primary retroperitoneal liposarcoma (PRPLS) is the most common soft tissue sarcoma of the retroperitoneum with high recurrence rate and short overall survival (OS).Methods: A retrospective review of 51 patients with PRPLS, treated between September 1, 2009 and November 30, 2020, was conducted to evaluate clinical outcomes of PRPLS resection. Patient demographics, histopathologic subtypes, overall survival (OS), progression-free survival (PFS), disease recurrence rate, and tumor stage were reviewed and analyzed. Univariate analysis was done to identify factors potentially affecting OS and PFS of PRPLS patients. Multivariate Cox proportional hazards analysis was used to evaluate the impact of various clinicopathological factors on OS and PFS of PRPLS patients.Results: Fifty-one PRPLS patients (28 Males, 23 Females; mean age 56.25 years) were evaluated. There was no significant effect of age, gender, contiguous organ resection, degree of differentiation and tumor size on the OS and PFS of the patients. Univariate analysis showed that negative surgical margin and early tumor stage significantly correlated with OS and PFS (all P < 0.001). Multivariate analysis showed that tumor stage [hazard ratio (HR) = 1.177, P = 0.001] was an independent predictors of poor progression-free survival, and surgical margins [HR = 4.0674 P = 0.038] and tumor stage [HR = 1.167 P = 0.001] were identified as independent predictors of poor overall survival.Conclusion: Negative surgical margin is a prognostic factor of OS, and can prolong the postoperative survival time of PRPLS patients. Tumor stage is a prognostic factor for OS and PFS, and can influence the survival of PRPLS patients. Earlier tumor stages of PRPLS are associated with significantly better outcomes.

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Section: Discussionmentioning

confidence: 99%

Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma

et al. 2021

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“…CT-scan or MRI are the most useful tools for investigation and evaluation of retroperitoneal mass [ 14 ]. Surgery is the mainstay of treatment for these cases and is curative with no recurrence following complete surgical excision [ 15 ]. The final diagnosis should always be confirmed with histopathology of the specimen.…”

Section: Discussionmentioning

confidence: 99%

Well-differentiated abdominal liposarcoma: experience of a tertiary care center

et al. 2015

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BackgroundWe presented abdominal liposarcoma cases diagnosed and managed in a tertiary care center and also conducted a literature review on main features of this tumor.MethodsChart reviews of eight cases were conducted, and clinical, surgical, histopathological, and follow-up data were recorded.ResultsOverall, complete surgical resection was performed with adjacent organ resection in 25% of cases, and radiotherapy was not administered. Recurrence was developed in only one case and died after 2 years and 3 months, and other cases are under follow-up without recurrence. Histopatological examinations revealed findings of well-differentiated liposarcoma.ConclusionsAccording to our surgical experience, the surgical margin positivity may not be a determining factor for the survival of patients with well-differentiated liposarcoma, and in the absence of macroscopic invasion, adjacent organ resection may not be required. Radiotherapy may not be preferred when complete resection of abdominal mass was achieved.

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“…In our day, the only treatment for retroperitoneal liposarcomas is en bloc R0 resection [2,5,6,9]. There is not enough evidence regarding radiotherapy and chemotherapy modalities [2,5,6,9]. The most important prognostic factors are R0 resection and tumor histology [3,9].…”

Section: Discussionmentioning

confidence: 99%

Coincident retroperitoneal and sigmoid colon liposarcoma: A rare occurrence

Urgancı¹,

Oymacı²,

Vardar³

et al. 2015

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor.

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Large Retroperitoneal Liposarcoma – A Series of Five Cases

Cited by 9 publications

References 21 publications

Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma

Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma

Well-differentiated abdominal liposarcoma: experience of a tertiary care center

Coincident retroperitoneal and sigmoid colon liposarcoma: A rare occurrence

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