Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov, Alexander; Medina‐Gomez, Carolina; Bacigalupe, Rodrigo; Radjabzadeh, Djawad; Wang, Jun; Demirkan, Ayşe; Roy, Caroline; Garay, Juan A. Raygoza; Finnicum, Casey T.; Liu, Xingrong; Zhernakova, Daria V.; Bonder, Marc Jan; Hansen, Torben; Frost, Fabian; Rühlemann, Malte; Turpin, Williams; Moon, Jee-Young; Kim, Hanna; Lüll, Kreete; Barkan, Elad; Shah, Shiraz A.; Fornage, Myriam; Szopinska-Tokov, Joanna; Wallen, Zachary D.; Borisevich, Dmitrii; Agréus, Lars; Andréasson, Anna; Bang, Corinna; Bedrani, Larbi; Bell, Jordana T.; Bisgaard, Hans; Boehnke, Michael; Boomsma, Dorret I.; Burk, Robert D.; Claringbould, Annique; Croitoru, Kenneth; Davies, Gareth E.; Duijn, Cornelia M. van; Duijts, Liesbeth; Falony, Gwen; Fu, Jingyuan; Graaf, Adriaan van der; Homuth, Georg; Hughes, David A.; IJzerman, Richard G.; Jackson, Matthew A.; Jaddoe, Vincent W.V.; Joossens, Marie; Jørgensen, Torben; Keszthelyi, Dániel; Knight, Rob; Laakso, Markku; Laudes, Matthias; Launer, Lenore J.; Lieb, Wolfgang; Lusis, Aldons J.; Masclee, Ad; Moll, Henriëtte A.; Mujagic, Zlatan; Qi, Qibin; Rothschild, Daphna; Shin, Hocheol; Sørensen, Søren J.; Steves, Claire J.; Thorsen, Jonathan; Timpson, Nicholas J.; Tito, Raúl Y.; Vieira-Silva, Sara; Völker, Uwe; Völzke, Henry; Võsa, Urmo; Wade, Kaitlin H; Walter, Susanna; Watanabe, Kyoko; Weiß, Stefan; Weiß, Frank Ulrich; Weissbrod, Omer; Westra, Harm-Jan; Willemsen, Gonneke; Payami, Haydeh; Jonkers, Daisy; Vásquez, Alejandro Arias; Geus, Eco J. C. de; Meyer, Katie A.; Stokholm, Jakob; Segal, Eran; Org, Elin; Wijmenga, Cisca; Kim, Hyung-Lae; Kaplan, Robert C.; Spector, Tim D.; Uitterlinden, André G.; Rivadeneira, Fernando; Franke, André; Lerch, Markus M.; Franke, Lude; Sanna, Serena; D’Amato, Mauro; Pedersen, Oluf; Paterson, Andrew D.; Kraaij, Robert; Raes, Jeroen; Zhernakova, Alexandra

doi:10.1038/s41588-020-00763-1

Cited by 1,115 publications

(991 citation statements)

References 86 publications

(151 reference statements)

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“…Recent studies have reported that the interplay of gut microbiota with host genetic variation is crucial to tumor development, 3,23 and host genetic factors can shape the microbial composition. 24 We therefore extended our analyses to decipher the correlation between intra-neoplasia microbial community and host KRAS mutation or MSI. Several microbes were identified to be strongly associated with these host genetic mutations.…”

Section: Discussionmentioning

confidence: 99%

Microbial Community Heterogeneity Within Colorectal Neoplasia and its Correlation With Colorectal Carcinogenesis

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Microbial Community Heterogeneity Within Colorectal Neoplasia and its Correlation With Colorectal Carcinogenesis

et al. 2021

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“…It is known that our microbiome is changing with growing age. Indeed, both cell culture-dependent andindependent studies show that the gut microbiota of older people differs from that of younger adults (74). There is no chronological threshold or age at which the composition of the microbiota suddenly alters; rather, changes occur gradually with time.…”

Section: Variability In Response To Nutraceuticals Intake: the Role Of The Gut-brain Axis And The Microbiome During Aging And Neurodegenementioning

confidence: 99%

Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression

et al. 2021

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Emerging evidence is showing nutrition as a crucial factor in the high prevalence and incidence of neurodegenerative mental disorders. Preventive interventions on neuroinflammation seem to be able to interfere with neurodegeneration. Supplementation of essential nutrients, such as long-chain-polyunsaturated fatty acids, vitamin E and mineral elements, may minimize inflammation, enhancing antioxidative defense, and lowering the risk and incidence of age-related diseases, such as cardiovascular diseases and neurodegenerative diseases. This manuscript reviews the current evidence on the role of neuroinflammation in the pathophysiology of neurodegenerative and mental disorders, and preventive strategies for food supplementation in these neuropsychiatric diseases. Dietary supplementation-based strategies have been demonstrated to be effective in subjects with mild cognitive impairment, while weaker results have been obtained in patients with advance neurodegenerative disease. Adjunctive supplementation has also been demonstrated to improve depression, this being of marked benefit considering the comorbidity between cognitive impairment/dementia and depression. Further research is needed to improve the prescriptive precision of supplementation in patients, and to better understand potential interactions with clinical and pharmacokinetic factors.

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“…Associations between the human genome and microbiome composition have been extensively studied in recent years. Microbiome and host genetics are strictly correlated [88]: the first plays a role in human health and disease by influencing the host's traits, disease susceptibility, and treatment response; the second influences microbiome composition [89]. In particular, studies on twins demonstrated that the gut microbiomes of monozygotic (MZ) twins are significantly more similar than those of dizygotic (DZ) twins, indicating that host genetic factors are involved in modulating gut microbiome composition [88,90].…”

Section: Interactions Between Gut Microbiota and Host Genes 41 Heritability Of Gut Microbiomementioning

confidence: 99%

“…Microbiome and host genetics are strictly correlated [88]: the first plays a role in human health and disease by influencing the host's traits, disease susceptibility, and treatment response; the second influences microbiome composition [89]. In particular, studies on twins demonstrated that the gut microbiomes of monozygotic (MZ) twins are significantly more similar than those of dizygotic (DZ) twins, indicating that host genetic factors are involved in modulating gut microbiome composition [88,90]. The first study by Goodrich et al [91] was performed on a large cohort of MZ and DZ twin pairs (977 individuals), which allowed them to assess the impact of genotype and early shared environment on gut microbiota.…”

Section: Interactions Between Gut Microbiota and Host Genes 41 Heritability Of Gut Microbiomementioning

confidence: 99%

Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

Maglione

Zuccalà

Tosi

et al. 2021

Genes

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As a complex disease, Multiple Sclerosis (MS)’s etiology is determined by both genetic and environmental factors. In the last decade, the gut microbiome has emerged as an important environmental factor, but its interaction with host genetics is still unknown. In this review, we focus on these dual aspects of MS pathogenesis: we describe the current knowledge on genetic factors related to MS, based on genome-wide association studies, and then illustrate the interactions between the immune system, gut microbiome and central nervous system in MS, summarizing the evidence available from Experimental Autoimmune Encephalomyelitis mouse models and studies in patients. Finally, as the understanding of influence of host genetics on the gut microbiome composition in MS is in its infancy, we explore this issue based on the evidence currently available from other autoimmune diseases that share with MS the interplay of genetic with environmental factors (Inflammatory Bowel Disease, Rheumatoid Arthritis and Systemic Lupus Erythematosus), and discuss avenues for future research.

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Large-scale association analyses identify host factors influencing human gut microbiome composition

Cited by 1,115 publications

References 86 publications

Microbial Community Heterogeneity Within Colorectal Neoplasia and its Correlation With Colorectal Carcinogenesis

Microbial Community Heterogeneity Within Colorectal Neoplasia and its Correlation With Colorectal Carcinogenesis

Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression

Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

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