Large‐Scale Programmed Genome Rearrangements in Vertebrates

Smith, Jeramiah J.

doi:10.1002/9781118647110.ch2

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…Which forms of within-individual genome variation are stochastic versus fulfill a biological function remains elusive (box 1), as well as what biological function that might be. The latter is exemplified by the phenomenon of programmed DNA elimination, which has been proposed to either be a means to limit selfish genetic elements to the germline or to minimize antagonistic pleiotropy of genes that are beneficial for the germline but deleterious for the soma (Smith et al 2012; Wang and Davis 2014 ; Smith 2017) . Comparisons of closely related species are necessary to solve such “chicken or egg” problems, as well as developmental and functional genomics of key candidate genes across different developmental stages.…”

Section: Next Steps Toward Elucidating the Evolution Of Within-individual Genome Variationmentioning

confidence: 99%

New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction

Suh

Dion-Côté

2021

Genome Biology and Evolution

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Genomes can vary significantly even within the same individual. The underlying mechanisms are manifold, ranging from somatic mutation and recombination, development-associated ploidy changes and genetic bottlenecks, over to programmed DNA elimination during germline/soma differentiation. In this perspective piece, we briefly review recent developments in the study of within-individual genome variation in eukaryotes and prokaryotes. We highlight an SMBE 2020 virtual symposium entitled “Within-individual genome variation and germline/soma distinction” and the present Special Section of the same name in Genome Biology and Evolution, together fostering cross-taxon synergies in the field to identify and tackle key open questions in the understanding of within-individual genome variation.

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Section: Next Steps Toward Elucidating the Evolution Of Within-individual Genome Variationmentioning

confidence: 99%

New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction

Suh

Dion-Côté

2021

Genome Biology and Evolution

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Repetitive DNA: The Dark Matter of Avian Genomics

Weissensteiner

Suh

2019

Avian Genomics in Ecology and Evolution

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Mendelian nightmares: the germline-restricted chromosome of songbirds

et al. 2022

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Germline-restricted chromosomes (GRCs) are accessory chromosomes that occur only in germ cells. They are eliminated from somatic cells through programmed DNA elimination during embryo development. GRCs have been observed in several unrelated animal taxa and show peculiar modes of non-Mendelian inheritance and within-individual elimination. Recent cytogenetic and phylogenomic evidence suggests that a GRC is present across the species-rich songbirds, but absent in non-passerine birds, implying that over half of all 10,500 bird species have extensive germline/soma genome differences. Here, we review recent insights gained from genomic, transcriptomic, and cytogenetic approaches with regard to the genetic content, phylogenetic distribution, and inheritance of the songbird GRC. While many questions remain unsolved in terms of GRC inheritance, elimination, and function, we discuss plausible scenarios and future directions for understanding this widespread form of programmed DNA elimination.

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Large‐Scale Programmed Genome Rearrangements in Vertebrates

Cited by 4 publications

References 32 publications

New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction

New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction

Repetitive DNA: The Dark Matter of Avian Genomics

Mendelian nightmares: the germline-restricted chromosome of songbirds

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