Large‐scale purification of Qβ‐virus by differential centrifugation

Abstract

SummaryBacterial RNA virus, &a, has been purified in gram amounts by differential centrifugation. Final separation of the virus from host E. coli rRNA was based on the density differential in the pellet. The method provided a simplified alternative to the more conventional rate zonal or isopycriic zonal centrifugation techniques.