This paper summarizes the main factors affecting the large deformation of soft rock tunnels, including the lithology combination, weathering effect, and underground water status, by reviewing the typical cases of largely-deformed soft rock tunnels. The engineering geological properties of the rock mass were quantified using the rock mass block index (RBI) and the absolute weathering index (AWI) to calculate the geological strength index (GSI). Then, the long-term strength σr and the elastic modulus E0 of the rock mass were calculated according to the Hoek–Brown failure criterion and substituted into the creep constitutive model based on the Nashihara model. Finally, the creep parameters of the surrounding rock mass of the Ganbao tunnel were inverted and validated by integrating the on-site monitoring and BP neural network. The inversion results were consistent with the measured convergence during monitoring and satisfied the engineering requirements of accuracy. The method proposed in this paper can be used to invert the geological parameters of the surrounding rock mass for a certain point, which can provide important mechanical parameters for the design and construction of tunnels, and ensure the stability of the surrounding rock mass during the period of construction and the safety of the lining structure during operation.