Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes

Berklite, Lara; Mitchell, Stephanie L.; Wheeler, Sarah

doi:10.1016/j.clinbiochem.2022.09.001

Cited by 2 publications

(6 citation statements)

References 18 publications

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“…A recent retrospective review found that large CSF serologic panels (i.e. adenovirus, coxsackie and echoviruses, influenza, measles, lymphocytic choriomeningitis virus, HSV, mumps, and VZV viruses) for the diagnosis of viral meningoencephalitis failed to improve clinical decisions and outcomes [25].…”

Section: Viral Causesmentioning

confidence: 99%

Severe meningoencephalitis: epidemiology and outcomes

Thy,

de Montmollin,

Bouadma

et al. 2023

Current Opinion in Critical Care

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Purpose of review This article aims to provide an updated review on the epidemiology and outcomes of severe meningoencephalitis. Recent findings Meningoencephalitis is a critical medical condition characterized by inflammation in both the meninges and brain parenchyma. Bacterial, viral, or fungal infections are common causes, although noninfectious factors, such as autoimmune causes, can also contribute. In patients requiring intensive care, meningoencephalitis is associated with a severe prognosis, including mortality rates ranging from 11 to 25% and functional disability in 15–25% of survivors. Recent multicenter studies have identified several parameters linked to poor outcomes, including older age, immunocompromised status, focal neurologic signs, abnormal brain imaging, and delayed administration of antimicrobials. The use of new multiplex PCR techniques for diagnosis has generated debate based on recent data. Investigation is still needed to determine the effectiveness of adjunctive therapies, including seizure prophylaxis, and adjunctive steroids for nonbacterial causes. Summary Recent multicenter studies have enhanced our understanding of the current epidemiology and outcomes of severe meningoencephalitis in adult patients.

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Section: Viral Causesmentioning

confidence: 99%

Severe meningoencephalitis: epidemiology and outcomes

Thy,

de Montmollin,

Bouadma

et al. 2023

Current Opinion in Critical Care

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show abstract

“…Characteristics of the infection: Meningoencephalitis involves inflammation of the meninges (called meningitis) and inflammation of the brain (called encephalitis). Most meningoencephalitis is caused by viruses; in which case we are talking about viral meningoencephalitis[ 81 , 82 ]. The most common signs of infection include fever, sensitivity to light, headache, stiff neck, hallucinations, personality changes, thinking problems, fatigue, unconsciousness[ 81 - 83 ].…”

Section: Spinal Infectionsmentioning

confidence: 99%

“…Most meningoencephalitis is caused by viruses; in which case we are talking about viral meningoencephalitis[ 81 , 82 ]. The most common signs of infection include fever, sensitivity to light, headache, stiff neck, hallucinations, personality changes, thinking problems, fatigue, unconsciousness[ 81 - 83 ].…”

Section: Spinal Infectionsmentioning

confidence: 99%

“…CT is usually used only as a screening test and is performed before a neurological examination or when MRI cannot be performed[ 81 , 82 ]. Echoencephalography measures brain waves through electrodes placed in the brain.…”

Section: Spinal Infectionsmentioning

confidence: 99%

“…A lumbar puncture involves the aspiration of a sample of cerebrospinal fluid with a needle. The sample is then examined for the presence of inflammatory cells, proteins and organisms[ 81 , 82 , 86 ].…”

Section: Spinal Infectionsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical infections in neurosurgical oncology: An overview

Velnar¹,

Kocivnik²,

Bosnjak³

2023

World J Clin Cases

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Central nervous system (CNS) infections are urgent conditions with high morbidity and mortality. Bacteria, viruses, parasites or fungi can cause them. Intracranial infections after craniotomies are an important complication of treatment, especially in oncological patients that are already immunologically compromised due to the disease and treatment. The consequence of CNS infections in oncological patients includes longer treatment with antibiotics, additional surgical procedures, higher treatment costs and poorer treatment outcomes. Additionally, the management of primary pathology may be prolonged or postponed as a result of the active infection. By introducing new and improved protocols, tightening controls on their implementation, constantly educating the entire team involved in patient treatment and educating both patients and relatives, the incidence of infections can be reduced effectively.

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Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes

Cited by 2 publications

References 18 publications

Severe meningoencephalitis: epidemiology and outcomes

Severe meningoencephalitis: epidemiology and outcomes

Clinical infections in neurosurgical oncology: An overview

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