Larvicidal activity against Aedes aegypti of some plants native to the West-Central region of Brazil

Garcez, Walmir Silva; Garcez, Fernanda Rodrigues; Silva, Lilliam M. G. E. da; Hamerski, Lidilhone

doi:10.1016/j.biortech.2009.06.092

Cited by 57 publications

(37 citation statements)

References 12 publications

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“…Hence, there has been an increasing interest in the development of alternative methods of mosquito control which are less hazardous to humans and other living organisms. In this regard, plantderived compounds have emerged as good candidates, not only as new effective tools in vector management but also as environmentally safer agents (Garcez et al 2009;Govindarajan et al 2011;Kalaivani et al 2011;Prophiro et al 2011;Kanis et al 2011). The present study evaluated the effect of a novel herbal formulation PONNEEM prepared from A. indica and P. glabra oils to minimize human vector mosquitoes.…”

Section: Discussionmentioning

confidence: 98%

A novel herbal formulation against dengue vector mosquitoes Aedes aegypti and Aedes albopictus

Maheswaran¹,

Ignacimuthu²

2011

Parasitol Res

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The objective of this study was to develop a herbal formulation to control dengue vector mosquitoes. PONNEEM, a novel herbal formulation prepared using the oils of neem (Azadirachta indica), karanj (Pongamia glabra) and their extracts, was tested for larvicidal, ovicidal and oviposition deterrent activities against Aedes aegypti and Aedes albopictus at 1, 0.5, 0.3 and 0.1 ppm concentrations. Cent percent larvicidal and ovicidal activities were observed at 0.1 ppm in the two mosquito species under laboratory and sunlight-exposed conditions up to 12 months from the date of manufacture. Oviposition deterrent activity of 69.97% and 71.05% was observed at 1 ppm concentration of PONNEEM against A. aegypti and A. albopictus, respectively. Reduction in enzyme levels for α-esterase was 0.089 ± 0.008 and 0.099 ± 0.140 μg napthol produced/min/mg larval protein; for β-esterase, it was 0.004 ± 0.009 and 0.001 ± 0.028 μg napthol produced/min/mg larval protein; for glutathione S-transferase, it was 10.4814 ± 0.23 and 11.4811 ± 0.21 μmol/min/mg larval protein and for total protein, it was 0.177 ± 0.010 and 0.008 ± 0.005 mg/individual larva in treated groups of A. aegypti and A. albopictus, respectively. The nontarget organisms such as Gambusia affinis and Diplonychus indicus were not affected. No mortality was observed in control. PONNEEM can be used effectively for the management of human vector mosquitoes.

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Section: Discussionmentioning

confidence: 98%

A novel herbal formulation against dengue vector mosquitoes Aedes aegypti and Aedes albopictus

Maheswaran¹,

Ignacimuthu²

2011

Parasitol Res

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“…Flavonoids isolated from the leaves of Polygonum senegalese Meissn exhibited insecticidal and A. aegypti larvae growth inhibitory activity, even at low concentrations (GIKONYO et al, 1998;GARCEZ et al, 2009). The species that showed strong larvicidal activity against A. aegypti, with LC 50 values between 80 and 470 g L -1 , belonged to the Rubiaceae family, and this activity has been related to bioactive flavonoids.…”

Section: Resultsmentioning

confidence: 99%

Phytochemistry and larvicidal activity of Spermacoce latifolia Aubl. (Rubiaceae) in the control of Aedes aegypti L. (Culicidae)

et al. 2015

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ABSTRACT:In the search for alternative ways to control Aedes aegypti with minimal environmental impact and in a manner that preserves human health, this study sought to evaluate the larvicidal effect of the invasive and antioxidant Spermacoce latifolia plant by performing a phytochemical study. Phytochemical screenings were done according to characterization reactions and thin layer chromatography. Phenolics compounds content (Folin-Ciocalteu's) and flavonoids (AlCl 3 ) spectrophotometric was performed, and the antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH). The phytochemical results revealed the presence of phenolic, flavonoid, tannin, steroid, free triterpene, coumarin, and alkaloid compounds. The content of total phenols (TPs) (482.7 ± 1.8 mg mgGA g -1 ) and flavonoids (165.4 ± 1.5 mg QE g -1 ) accounted for the antioxidant activity of 150 µg mL -1 methanolic extract. In the proposed bioassays, groups of 25 third-stage larvae were challenged at different concentrations of plant crude extract (1.0, 0.5, 0.25, and 0.1 mg mL -1 ) of weight per volume in four replicates. In multiple concentration tests, the concentrations were selected to range from 0 % to 100 % mortality after 24 hours of contact with the solution. Toxicity was defined as the inhibition or total inactivity of the larvae. It was concluded that the methanol extract had an LC 50 of 0.625 mg mL -1 , indicating its potential use as a larvicide against A. aegypti and linking its activity to its phenolic and flavonoid components.

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“…Oxoaporphines and aporphines have been reported to have larvicidal activity against A. aegypti larvae. For example, liriodenine and (+)-dicentrine have been reported as larvicidal secondary metabolites with LD 50 at 3.6 and 30.2 ppm after 24 hours [20–21]. Although the larvae belong to a different genus, they are from the same family, and the mode of action of these alkaloids could be the same.…”

Section: Resultsmentioning

confidence: 99%

Zanthoxoaporphines A–C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae)

Samita¹,

Sandjo²,

Ndiege³

et al. 2013

Beilstein J. Org. Chem.

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SummaryThe bioassay-guided purification of Zanthoxylum paracanthum (Rutaceae) extracts led to the isolation of three new alkaloids, namely 1-hydroxy-10-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine A, 2), 1-hydroxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine B, 3) and 1,8-dihydroxy-9-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxaporphine C, 4), and a known lignan identified as sesamin (1). Isolation and purification of the constituent compounds was achieved through conventional chromatographic methods. The chemical structures of the isolated compounds were determined on the basis of UV, IR, NMR and MS data, and confirmed by comparison with those reported in the literature. The larvicidal activity of some of the isolated compounds was investigated by using third-instar Anopheles gambiae larvae.

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Larvicidal activity against Aedes aegypti of some plants native to the West-Central region of Brazil

Cited by 57 publications

References 12 publications

A novel herbal formulation against dengue vector mosquitoes Aedes aegypti and Aedes albopictus

A novel herbal formulation against dengue vector mosquitoes Aedes aegypti and Aedes albopictus

Phytochemistry and larvicidal activity of Spermacoce latifolia Aubl. (Rubiaceae) in the control of Aedes aegypti L. (Culicidae)

Zanthoxoaporphines A–C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae)

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