Larvicidal spirobisnaphthalenes from the endophytic fungus Berkleasmium sp. against Aedes albopictus

Abstract

The results indicated that the spirobisnaphthalenes derived from the endophytic fungus Berkleasmium sp. could be promising leads for the development of new larvicides against A. albopictus.

Dibenzo-α-pyrones: a new class of larvicidal metabolites againstAedes aegyptifrom the endophytic fungusHyalodendriellasp. Ponipodef12

“…A recent example was the isolation of larvicidal spirobisnaphthalenes from the endophytic fungus Berkleasmium sp. Dzf12, which showed larvicidal activity against A. albopictus . In our course to search for new larvicides from fungal endophytes, the crude extract of Hyalodendriella sp.…”

Total synthesis of Palmarumycin BGs, C1and Guignardin E

“…These results indicated that the chlorine atom at C-3 and the carbonyl at C-4 play a critical role for cytotoxicity. 23,24…”

“…21 Because of the interesting larvicidal activity of Palmarumycin B 6 against Aedes albopictus, its limited access in the fermentation extract of the endophytic fungus Berkleasmium sp., and the importance of the halogen atom in the A-ring. 22,23 the total synthesis and structure revision of Palmarumycin B 6 were achieved, and found that the location of the chlorine atom plays a crucial role for the larvicidal activity against A. albopictus in the previous report. 24 The antitumor activities of Palmarumycin BG5, Guignardin E and Palmarumycin C 1 aroused our enthusiasm to gain insights into the structure-activity relationships of these spirobisnaphthalene compounds and explore their mode of action.…”

Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12

“…Compounds 1 and 2 were tested for their larvicidal activity against the fourth-instar larvae of Aedes aegypti as described previously [8]. Rotenone was used as the positive control.…”

“…Plant endophytic fungi have been considered as an abundant and important microbial resource for discovering novel larvicidal compounds [5][6][7], such as palmarumycins C 8 and B 6 from Berkleasmium sp. [8]. Hyalodendriella sp.…”