Laryngeal Chondrosarcoma

Potochny, Evelyn M.; Huber, Aaron R

doi:10.1007/s12105-013-0483-7

Cited by 19 publications

(21 citation statements)

References 4 publications

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“…These tumors are often slow growing, have low metastatic potential, and tend to present with locally obstructive symptoms, such as dyspnea and dysphagia. Conservative surgical intervention is the most common modality of treatment according to case reports and a population‐based study . In our analysis of 284 hard tissue sarcomas, almost all were exclusively treated with surgery alone (70.8%), with only a small minority receiving RT, CT, or CRT (0.0%–7.0%).…”

Section: Discussionmentioning

confidence: 92%

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

et al. 2019

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Objectives: To analyze the incidence and clinical profile of nonsquamous cell (non-SCC) laryngeal carcinomas and to analyze the effect of surgery on survival.Study Design: A retrospective analysis of the National Cancer Database (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014).Methods: Adult patients with non-SCC laryngeal cancers were divided into six major histological subtypes. A descriptive clinical profile was obtained for non-SCC patients, and multivariate regressions were performed to analyze the effect of surgery on survival within the non-SCC cohort.Results: We identified 878 cases of non-SCC laryngeal cancers, representing 1.02% of all malignant laryngeal cancers. Neuroendocrine tumors and bone/cartilage sarcomas made up the largest groups (37.02% and 32.35%, respectively). Metastasis (M) was higher in neuroendocrine tumors, representing 19.1% of those with known clinical M stages. Of those treated, the majority of patients with bone/cartilage sarcomas (80.9%) and minor salivary gland tumors (82.6%) received surgery as part of their treatment. Survival varied significantly based upon histology, with bone/cartilage sarcomas having the highest 5-year survival at 90.4%, and neuroendocrine tumors exhibiting the poorest 5-year survival at 25.7%. Multivariate analyses found surgery to be significantly associated with improved survival (hazard ratio: 0.679; 95% confidence interval: 0.472-0.976; P = 0.036). The specific surgical method (i.e., local excision vs. partial vs. total laryngectomy) did not have any effect on survival.Conclusion: Approximately 1% of all malignant laryngeal cancers are non-SCC in origin. At presentation, neuroendocrine tumors have the highest rate of distant metastasis and have the worst prognosis of the non-SCC cancers. Most non-SCC patients received surgery as part of their treatment regimen.

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Section: Discussionmentioning

confidence: 92%

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

et al. 2019

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“…Considering the natural history, conservative surgery has been the preferred surgical option for LCS in recent years. [ 9 , 18 , 19 ] Rather than total laryngectomy, the surgical methods such as CO 2 laser resection, hemicricoidectomy, or hemilaryngectomy are the treatment of choice for low-grade LCS. Conservative surgery can preserve the structural and functional integrity of the larynx, which is very important for patient quality of life.…”

Section: Discussionmentioning

confidence: 99%

Recurrent chondrosarcoma of the larynx

et al. 2016

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BackgroundLaryngeal chondrosarcoma (LCS) is a rare laryngeal tumor that most commonly originates from the cricoid cartilage. The current trend for treatment of low-grade LCS is function-sparing surgical option with negative margins.Case summaryWe reported here a case of a 63-year-old male patient with a 3-month history of progressive hoarseness and throat pain. The patient had undergone surgical resection of a laryngeal mass 2 years prior. A supracricoid partial laryngectomy was performed this time. Histological examination supported the diagnosis of low-grade chondrosarcoma. Three years later, the radiological and clinical findings showed no evidence of recurrence.ConclusionCurrently, total laryngectomy is preferred for patients with recurrent low-grade LCS. However, the literature review and our case suggest that a second function-preserving procedure may be a reasonable choice for recurrent LCS.

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“…Moreover, CT scans document even minimal deposits of calcifications, which cannot be detected on conventional radiographs (5,3). This patient's pre-operative CT scan revealed an expansive mass of 6.0×5.0 cm in the posterior area of the left thyroid cartilage lamina without gross inflation or cortical breakage (Fig.…”

Section: Case Reportmentioning

confidence: 99%

“…Chondrosarcoma of the larynx is also uncommon, comprising only 1% of laryngeal malignancies (1), of which approximately 20% arise from the thyroid cartilage, the second most common site after the posterior lamina of the cricoid cartilage (2). The pathogenesis of chondrosarcoma of the thyroid cartilage is unknown, although a recent review suggested that several precipitating factors, such as multiple hereditary exostoses, Ollier's disease, chondromyxoid fibroma, and previous irradiation may contribute to its tumorigenesis (3). However, almost all reported cases originate from Europe or America.…”

Section: Introductionmentioning

confidence: 99%

Primary chondrosarcoma of the thyroid cartilage: Surgery-based management of a rare case

et al. 2016

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In this study, we present a case of a 52-year-old male with a chondrosarcoma of the left lamina of the thyroid cartilage. Pre-operative evaluations detected typical calcifications and delineated the extent of the tumor. The patient underwent a total laryngectomy to ensure the complete resection of the tumor. The tumor was histopathologically found to consist of chondrocytes in a hyaline cartilage matrix. The patient's post-operative course has been successful apart from the permanent tracheostomy. Herien, we discuss the methods and rationales for the diagnosis and management of and recovery from this rare tumor, and also provide a review of the literature.

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Laryngeal Chondrosarcoma

Cited by 19 publications

References 4 publications

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

Recurrent chondrosarcoma of the larynx

Primary chondrosarcoma of the thyroid cartilage: Surgery-based management of a rare case

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