Laryngeal Involvement in Progressive Nodular Histiocytosis

Karimi, Kian; Jadidian, Armon; Glavin, Frederick L.; Chhatwal, Hardeep; Adelson, Robert T.

doi:10.1001/archoto.2010.49

Cited by 6 publications

(14 citation statements)

References 12 publications

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“…Mucosal involvement has been occasionally reported, including the publication by Taunton and colleagues [1], who were the fi rst to describe this disease. In one patient, extensive laryngeal involvement led to respiratory diffi culty and resulted in laser removal of the nodular infi ltrates, which was also necessary in patient 1 [23]. Taunton and colleagues also described conjunctival involvement as seen in our patient 2.…”

Section: Commentsmentioning

confidence: 71%

Progressive nodular histiocytosis

Hilker

Kovneristy²,

Varga³

et al. 2012

J Deutsche Derma Gesell

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SummaryProgressive nodular histiocytosis (PNH) represents a very rare type of non-Langerhans cell histiocytosis (NLCH). It can be distinguished from other types by the occurrence of yellow to red-brown papules and nodules measuring a few centimeters in size. Histologically the nodules represent spindle-cell xanthogranulomas. We report on two new cases of PNH with novel clinical symptoms. In the first case, the patient had microcytic anemia due to massive iron deposition in the nodules and a progressively worsening limp due to involvement of the soles. The complex therapeutic challenge was effectively managed by successive surgical ablation of all visible lesions. The second patient had epibulbar infiltrates. The clinical variability of PNH leads to considerable overlap with other forms of NLCH.

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Section: Commentsmentioning

confidence: 71%

Progressive nodular histiocytosis

Hilker

Kovneristy²,

Varga³

et al. 2012

J Deutsche Derma Gesell

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“…claim to have documented the first case with extensive laryngeal and pharyngeal involvement causing dyspnea and dysphagia due to partial airway obstruction. [17] Hence after extensive search in the literature, only one previous case of PNH with laryngeal involvement could be identified (to the best of our knowledge). The presence of histiocytic infiltrates features in all forms of histiocytoses and is characterized by spindle-shaped, vacuolated, stellate, and foamy cells, all of which express immunohistochemical macrophage markers such as CD68.…”

Section: Discussionmentioning

confidence: 99%

“…[1] First described by Taunton et al . in 1978,[2] it is one of the several variants, such as xanthoma disseminatum, generalized eruptive histiocytosis, multicentric reticulohistiocytosis and so on.…”

Section: Introductionmentioning

confidence: 99%

“…In the past, there has been a great deal of confusion in classifying the various histiocytoses owing to rarity with which they were encountered as well as the tremendous overlap, both clinically and histologically, observed between these diseases. [1] Clinical, histopathological, and immunohistochemical correlation is required for differentiating PNH from other histiocytic disorders.…”

Section: Introductionmentioning

confidence: 99%

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Laryngeal involvement with fatal outcome in progressive nodular histiocytosis: A rare case report

Salunke

Belgaumkar

Chavan

et al. 2016

Indian Dermatol Online J

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Progressive nodular histiocytosis (PNH) represents a very rare type of non-Langerhans cell histiocytosis. It is characterized by progressive appearance of papules and nodules without spontaneous resolution. We report a 60-year-old patient with novel clinical features in the form of extensive noduloulcerative lesions, ichthyotic patches, and laryngeal involvement culminating in fatal outcome prior to therapeutic intervention. Although the presenting features were baffling, histopathology and immunohistochemistry clinched the diagnosis of PNH.

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“…Very few universally accepted reports of PNH exist, and these cases have been given diverse nomenclature 22–29 …”

Section: Discussionmentioning

confidence: 99%