Laryngeal Pemphigoid Evolution and Response to Treatment

Barmatz, Shira; Baniel, Alain; Eremenko, Ron; Neiderman, Narin N. Carmel; Wasserzug, Oshri; Sprecher, Eli; Oestreicher‐Kedem, Yael

doi:10.1016/j.jvoice.2021.01.012

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…A previous study showed that laryngeal involvement in BP patients was more common than previously reported, with an estimated minimum prevalence of 4.9% 1 . Although BP patients with laryngeal lesions are usually asymptomatic, they can present with hoarseness, stridor, with or without dyspnea in severe cases 4 . We were unable to find previous reports of cases of BP that presented with acute progressive laryngeal involvement requiring emergency tracheostomy.…”

Section: Figurementioning

confidence: 62%

“…1 Although BP patients with laryngeal lesions are usually asymptomatic, they can present with hoarseness, stridor, with or without dyspnea in severe cases. 4 We were unable to find The majority of penile cancer (PC) is squamous cell in nature, usually diagnosed by dermatologists or urologists. Organ preserving treatments (OPTs) are recommended for the treatment of localized squamous cell carcinoma (SCC).…”

mentioning

confidence: 99%

“…The average lesion diameter before surgery was 25.4 mm (mean range: 19-28.7 mm), with a mean follow-up after MMS of 54.2 months (mean range: 17.5-97.4 months). [3][4][5][6][7][8][9] Nineteen tumors locally recurred after surgery, generally treated with a second MMS. When compared to the literature, this local recurrence rate (LRR) of 7.7% is lower than the LRR of 21.2% reported for penile sparing surgeries in penile carcinoma.…”

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confidence: 99%

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Bullous pemphigoid with laryngeal involvement requiring emergency tracheostomy

Iinuma¹,

Hayashi²,

Sato³

et al. 2021

Int J Dermatology

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Bullous pemphigoid with laryngeal involvement requiring emergency tracheostomyDear Editor, Bullous pemphigoid (BP) is a common autoimmune bullous disease affecting the skin and mucous membranes, particularly the oral mucosa. 1 However, patients with BP rarely present with involvement of the laryngeal mucosa. We report a case of BP with laryngeal involvement that presented as severe airway narrowing, requiring an emergency tracheostomy.A 76-year-old Japanese woman was referred to our department with a 2-week history of blisters and erosions on the trunk and extremities. The patient also complained of gradually worsening hoarseness and stridor for 2 days. Computed tomography of the neck revealed glottic and subglottic edema and airway narrowing (Fig. 1a). Fiber-optic laryngoscopy performed

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Section: Figurementioning

confidence: 62%

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confidence: 99%

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confidence: 99%

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Bullous pemphigoid with laryngeal involvement requiring emergency tracheostomy

Iinuma¹,

Hayashi²,

Sato³

et al. 2021

Int J Dermatology

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“…The scarring can interfere with the patients’ normal functions, e.g., vision, food intake, miction, and sexual intercourse, thus have a serious impact for their quality of life ( 2 ). Larynx involvement might even be fatal due to breathing impairment ( 3 ). The diagnosis is based on clinical findings and the detection of autoantibodies against known autoantigens at the basement membrane, primarily BP180, BP230, laminin 332, and collagen VII ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult

2022

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A male patient presented to our department at the age of 23 suffering from recurrent painful erosions in the urethral outlet area. In closer clinical examination gingival erosions, primarily around the teeth were identified as well. Indirect immunofluorescence on salt split skin with epidermal IgG deposition and positive anti-BP230 IgG ELISA diagnostics hinted toward the presence of mucous membrane pemphigoid (MMP). Direct immunofluorescence from oral mucosa confirmed the diagnosis. MMP in young adulthood is an underdiagnosed disease and latency of diagnosis was around 4 years in our case. Treatment with systemic glucocorticosteroids and dapsone led to clinical remission, prohibiting the development of MMP manifestations in further organs and complications associated with the disease, e.g., scar formation and miction problems.

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Pembrolizumab‐Associated Bullous Pemphigoid with Laryngeal Involvement

Triantafillou,

Leahy

2024

The Laryngoscope

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Pembrolizumab is a monoclonal antibody with increasing use in many malignancies. We describe a case of pembrolizumab‐associated bullous pemphigoid (BP) with laryngeal involvement in a 69‐year‐old male patient. Diagnosis was made after 2 months of symptoms via biopsy of concurrent, easily accessible cutaneous lesions. Pembrolizumab was discontinued and the patient was started on steroids and dupilumab with ultimate resolution of his cutaneous and laryngeal lesions while on immunosuppression. This case report describes the third case of pembrolizumab‐associated laryngeal pemphigoid to increase awareness of this rare immune‐related adverse effect. Laryngoscope, 2024

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Laryngeal Pemphigoid Evolution and Response to Treatment

Cited by 5 publications

References 26 publications

Bullous pemphigoid with laryngeal involvement requiring emergency tracheostomy

Bullous pemphigoid with laryngeal involvement requiring emergency tracheostomy

Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult

Pembrolizumab‐Associated Bullous Pemphigoid with Laryngeal Involvement

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