2021
DOI: 10.1002/hed.26604
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Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases

Abstract: Background Laryngeal sarcoma is rare. We performed a systematic review and individual patient analysis to evaluate the patterns of care, prognostic factors, and role of radiotherapy in laryngeal soft tissue sarcoma. Methods A systematic search on PubMed and Google scholar was done. An individual patient data analysis was done. Results Of the 300 cases of laryngeal sarcoma, 80% underwent surgery. 44% underwent larynx preservation surgery and 25% received radiotherapy with surgery. Median progression free surviv… Show more

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Cited by 5 publications
(15 citation statements)
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“…Whereas laryngeal sarcoma is associated with favorable survival, poor prognosis depends significantly on tumor T-stage and location, which are the two most important factors followed by vocal cord movement, anterior history of head and neck radiation therapy and necrosis. 15 , 16 A systematic review published in 2020, included 300 cases of which 240 patients undergoing surgery (total laryngectomy, preservation surgery), 64 patients receiving 60 Gy (33.5–75 Gy) of adjuvant RT, and 12 receiving exclusive RT. Median progression-free survival (PFS) was 48 months, and 224 months of overall survival (OS) were noted in the entire cohort.…”
Section: Discussionmentioning
confidence: 99%
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“…Whereas laryngeal sarcoma is associated with favorable survival, poor prognosis depends significantly on tumor T-stage and location, which are the two most important factors followed by vocal cord movement, anterior history of head and neck radiation therapy and necrosis. 15 , 16 A systematic review published in 2020, included 300 cases of which 240 patients undergoing surgery (total laryngectomy, preservation surgery), 64 patients receiving 60 Gy (33.5–75 Gy) of adjuvant RT, and 12 receiving exclusive RT. Median progression-free survival (PFS) was 48 months, and 224 months of overall survival (OS) were noted in the entire cohort.…”
Section: Discussionmentioning
confidence: 99%
“…Authors ended-up suggesting that adjuvant RT may be justified in patients with high-risk factors: tumor size > 3 cm, cartilage invasion, local or distant metastasis. 16 …”
Section: Discussionmentioning
confidence: 99%
“…1,2 Laryngeal sarcomas account for less 1% of laryngeal neoplasms. [1][2][3][4][5] Various sarcoma types have been reported to occur in the larynx. Their nomenclature and classification are similar to their soft tissue counterpart.…”
Section: Discussionmentioning
confidence: 99%
“…1,2 The vast majority of laryngeal tumor are carcinomas, and squamous cell carcinoma is the most common histologic type. [1][2][3][4][5] Nonepithelial tumors constitute approximately 5% of all laryngeal neoplasms that include sarcoma, lymphoma, and melanoma. 1,2 Laryngeal sarcomas account for less 1% of laryngeal neoplasms.…”
Section: Discussionmentioning
confidence: 99%
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