Laryngeal thrush: Merf experience

Abstract

Fungal infection of the larynx is a relatively uncommon condition. The lesions max be confined to the vocal folds or may involve various other sites in the larynx. There is, invariably, a risk factor that predisposes to fungal infection viz. immune deficiency, inhaled or systemic steroids, antibiotic usage, etc. These lesions may mimic malignancy or a premalignant condition. There have been very few cases of laryngeal thrush reported in the literature. Awareness of this entity is essential because the management depends on an accurate diagnosis. These lesions invariably respond to a course of oral antifungal therapy and correction of risk factors. We report 3 cases of laryngeal thrush.

Candidiasis Causing Vocal Fold Leukoplakia: Review of Clinical and Pathological Results of 289 Cases With Vocal Fold Leukoplakia

“…In this way, unnecessary interventions likely to cause damage or loss of function of vocal folds will be avoided. 6,8,10,14 In fact, not only candidiasis but also the possibility of malignancy should be excluded in vocal fold leukoplakia; biopsy is an important step in the diagnosis and follow-up of vocal fold leukoplakia. Lee and Cho 15 reported that they successfully treated vocal fold candidiasis leukoplakia by administering antifungal medication for 4 weeks, and during the 42nd month of the follow-up, the routine laryngoscopy performed revealed that the lesion recurred, and they detected squamous cells without the presence of candida after the biopsy.…”

“…In publications, it has been emphasized administration of oral fluconazole is effective in the treatment of candidiasis causing laryngeal leukoplakia and that recurrence of lesions after the treatment with oral fluconazole is rare. 9, [14][15][16] In the treatment of oropharynx and esophageal candidiasis, the first choice is fluconazole. The results of a 3-year study conducted in North and Latin America demonstrated that C. albicans and C. dubliniensis were the 2 species susceptible to azole most; C. parapsilosis, C. lusitaniae, and C. guillier-mondii complex was generally susceptible; the susceptibility of C. glabrata and C. tropicalis decreased; and C. krusei was intrinsically resistant.…”