LASCA with a small number of scatterers: Application for monitoring of microflow

Abstract

LASCA, combined with cross-correlation technique, has been applied for highresolution measurements of the velocity of microflow and its structure in small blood capillaries in vivo. Such measurements have been carried out for the first time behind the resolution limit of the optical system.

Could LASCA-imaging of GB-speckles be applied for a high discrimination and typing of pathogenic bacteria?

“…Such method of LASCA [ 15 ] was proposed more than 20 years ago. Previously, this method was used to diagnose the blood flow in normal state and under some pathological changes [ 16 , 17 ], to monitor of malignant tumor growth, to test the toxicity of the new-generation vaccine against very dangerous diseases [ 18 ], and to study the hydrodynamics of microflow in isolated blood vessel in the mesentery of white rats [ 19 ]. Relatively recently, essential progress has been achieved in the implementation of LASCA method to monitoring bacterial colony growth [ 20 ].…”

LASCA-imaging of gene-based speckles: application to detection of the gene polymorphism in a bacterial model

“…The method of LASCA [9,10] was proposed more than 20 years ago. Previously, this method has been used in the diagnosis of blood flow in either norm or for some pathological changes [11][12][13], for monitoring of the growth of malignant tumors, for testing the toxicity of new-generation vaccines against especially dangerous diseases [14], and in studying the hydrodynamics of microflow in isolated blood vessels in mesentery of white rats [15]. Recently, essential progress has been achieved with implementation of LASCA in monitoring the growth of bacterial colonies [16].…”