Laser‐Activatible PLGA Microparticles for Image‐Guided Cancer Therapy In Vivo

Sun, Yong; Wang, Yanjie; Niu, Chengcheng; Strohm, Eric M.; Zheng, Yuanyi; Ran, Haitao; Huang, Rongzhong; Zhou, Di; Gong, Yuping; Wang, Zhigang; Wang, Dong; Kolios, Michael C.

doi:10.1002/adfm.201402631

Cited by 63 publications

(42 citation statements)

References 43 publications

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“…Biocompatible metal NPs are generally employed to convert photons into thermal energy and induce the evaporation of liquid droplets. [21][22][23] The shallow penetration depth of the laser, however, substantially hinders its further clinical translation. It is noted that both ADV and ODV require a pre-determined tumor position to accomplish site-specific phase transformation for imaging and therapy, which means that these two modalities cannot intrinsically overcome the drawbacks of particle sizes of CAs or SAs for early diagnosis and efficient therapy of cancer.…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

et al. 2016

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The development of efficient strategies for in vivo stimuli-responsive cancer treatment and personalized biomedicine is a great challenge. To overcome the critical issues and limitations of traditional protocols using acoustic droplet vaporization and optical droplet vaporization in stimuli-responsive tumor treatment, we herein report a new strategy, magnetic droplet vaporization (MDV), based on nanobiotechnology, for efficient magnetic field-responsive cancer theranostics. Perfluorohexane (PFH)-encapsulated superparamagnetic hollow iron oxide nanoparticles with a high magnetic-thermal energy transfer capability quickly respond to an external alternating current (a.c.) magnetic field to produce thermal energy and raise the temperature of the surrounding tumor tissue. The encapsulated PFH, with a desirable boiling point of~56°C, can be vaporized to enhance the performance of ultrasound imaging of tumors, as systematically demonstrated both in vitro and in vivo. The magnetic-thermal energy transfer further ablated and removed tumors in mice tumor xenograft models. This unique MDV principle with high versatility and performance is expected to broaden the biomedical applications of nanotechnology and promote clinical translations of intelligent diagnostic and therapeutic modalities, especially for battling cancer.

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Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

et al. 2016

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“…Our in vivo experiments indicate that laser-stimulated PLGA particle vaporization caused the disruption of the vasculature and decreased blood perfusion which caused necrosis of tumor cells, thus limiting tumor growth [23]. The anti-cancer therapeutic effects could be further enhanced by incorporating a chemotherapeutic into the particle.…”

Section: Introductionmentioning

confidence: 87%

“…After the solvent was evaporated, the fluorinated GNPs were dissolved into PFH liquid. PLGA particles containing PFH with and without GNPs were prepared using a double emulsion solvent evaporation process [23,43]. Briefly, PLGA polymer (25 mg) and DiD or DiI (100 µg) were dissolved in dichloromethane (1 mL).…”

Section: Plga Particle Synthesismentioning

confidence: 99%

“…They were containing a perfluorohexane (PFH) liquid stabilized by Poly (lactide-co-glycolic acid) (PLGA) shells, with GNPs incorporated in the shells as the optical absorbers for PA/US imaging [23]. Perfluorocarbon (PFC) liquids have long been used as blood substitutes to carry oxygen in patients due to their chemical and biological inert, and non-toxic properties [24].…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods

Wang¹,

Strohm²,

Sun³

et al. 2016

Biomed. Opt. Express

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Abstract:In this study, optical-triggered multifunctional theranostic agents for photoacoustic/fluorescent imaging and cancer therapy have been developed. This system consists of a perfluorohexane liquid and gold nanoparticles (GNPs) in the core, stabilized by a Poly (lactide-co-glycolic acid) (PLGA) polymer shell. When cancer cells containing PLGAGNPs were exposed to laser pulses, cell viability decreased due to the vaporization of the particles in and around the cells. The particle chemo drug loading and delivery capacity was also investigated in vitro experiments. These particles show potential as photoacoustic imaging and therapy agents for future clinical translation in cancer therapy. lactide-co-glycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography," J.

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“…Upon laser irradiation, a liquid-to-gas phase transformation of PFCs takes place due to the temperature elevation via the conversion of laser energy. The resulting PFCs bubbles are capable of enhancing contrast of ultrasound/ photoacoustic imaging [39,40] and inducing cavitation for therapy [41][42][43] by the bubble formation and explosion. This kind of laser-induced phase transformation can be realized by the combination of PFCs droplets with various photosensitizers, such as indocyanine green (ICG)-loaded perfluorocarbon nanodroplets, gold nanoparticles and perfluorohexane liquid (PFH) co-loaded PLGA [42,43].…”

mentioning

confidence: 99%

Facile synthesis of liposome/Cu2−x S-based nanocomposite for multimodal imaging and photothermal therapy

Mou

Chen

et al. 2015

Sci. China Mater.

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A kind of multifunctional perfluoropentane (PFP) and ultrasmall Cu2−xS nanodots (u-Cu2−xS NDs) co-incorporated liposome (PFP@ u-Cu2 −xS NDs@liposome) nanocomposite has been facilely and successfully synthesized for enhanced ultrasound/infrared thermal/ photoacoustic multimodal imaging and photothermal therapy upon near infrared (NIR) laser irradiation. Such a liposome-based nanocomposite possesses a number of advantages, such as high dispersity and stability, excellent biocompatibility, small particle size (<100 nm), well-defined core/shell structure, strong NIR absorption and photo-triggered vaporization of PFP, etc. The detailed in vitro investigations demonstrate that the as-synthesized PFP@ u-Cu2−xS NDs@ liposome nanocomposite is capable of enhancing the contrasts of ultrasound/infrared thermal/photoacoustic multimodal imaging, and substantially improving the photothermal therapeutic efficacy. This novel liposome-based theranostic nanoplatform shows great potentials in the future cancer diagnosis and therapy. INTRODUCTIDNOver the past decades, billions of people have suffered from various cancers worldwide [1]. Fortunately, diverse diagnostic imaging technologies [2-4] and powerful therapeutic methodologies [5][6][7][8][9] have emerged for cancer theranostics. As a minimally invasive and potentially effective therapeutic technique compared with conventional approaches, photothermal therapy (PTT) [10][11][12][13], which utilizes photothermal agents to convert near-infrared (NIR) energy into hyperthermia to kill cancer cells, has receiv ed extensive interest in recent years. Especially, imaging-guided PTT [14][15][16][17] shows great promise in improved efficiency and bio-safety.Currently, ultrasound imaging [18][19][20] is believed to be one of the most widely used imaging tools in the clinic, owing to its considerably high resolution, deep tissue penetration, easy soft tissue recognition and low cost. However, the ultrasound waves are easily disrupted by air or gas and unable to penetrate bones [21]. Infrared thermal imaging [22][23][24] its high imaging speed, sensitivity and convenience, but it suffers from relatively low imaging resolution. Recently, the newly developed photoacoustic imaging [25-28] is emerging as a complementary imaging modality, which combines the high contrast of optical imaging and the high spatial resolution of ultrasound imaging. Therefore, the combination of ultrasound/infrared theramal/photoacoustic imaging techniques will bring unexpected potentials in offering more comprehensive and accurate information with the complementary features of these techniques. In addition, the ingenious strategy of the multimodal imaging-guided PTT will be more powerful and efficient in PTT pre-guidance, intra-monitoring and post-evaluation. Therefore, the exploration of such multifunctional theranostic na noplatforms, which combine both diagnostic and therapeutic functions to allow simultaneous multimodal imaging and therapy as well as the monitoring of tissue/organ's responses to the treatments, h...

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Laser‐Activatible PLGA Microparticles for Image‐Guided Cancer Therapy In Vivo

Cited by 63 publications

References 43 publications

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods

Facile synthesis of liposome/Cu2−x S-based nanocomposite for multimodal imaging and photothermal therapy

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