Laser acupuncture for depression: A randomised double blind controlled trial using low intensity laser intervention

Quah-Smith, Im; Smith, Caroline; Crawford, John D.; Russell, Janice

doi:10.1016/j.jad.2012.11.058

Cited by 56 publications

(30 citation statements)

References 38 publications

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“…LA showed a clinically and statistically significant benefit with reducing symptoms of depression on objective measures including different clinical scores [16]. LA at ST-36 elicited significant antinociceptive effects against acetic-acid- and formalin-induced behavior in rats, and this effect is mediated by activation of the opioidergic and serotonergic (5-HT1 and 5-HT2A receptors) systems [17].…”

Section: Discussionmentioning

confidence: 99%

Manual Acupuncture and Laser Acupuncture for Autonomic Regulations in Rats: Observation on Heart Rate Variability and Gastric Motility

Yang

Xin

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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This study focused on the effects of laser acupuncture (LA) and manual acupuncture (MA) at different acupoints on gastric motility and heart rate variability (HRV) simultaneously to elucidate the site specific effects of acupoints and the correlation between changes of gastric motility and low frequency/high frequency (LF/HF) ratio. Gastric motility and HRV were recorded before and during MA or LA. Stimulating PC-6 or ST-36 significantly enhanced gastric motility, while BL-21 caused no changes. In contrast, MA or LA at CV-12 significantly suppressed gastric motility. Stimulating PC-6 or ST-36 significantly increased heart rate (HR), while CV-12 or BL-21 induced no significant changes of HR. Stimulating PC-6 significantly increased LF/HF, while ST-36, CV-12, or BL-21 induced no significant effects. These results indicated that there was acupoint specificity in the effects of acupuncture on gastric motility and HRV. The stimulatory effect of MA and LA at PC-6 and ST-36 on HR was associated with sympathetic activity. The stimulatory effect of MA or LA at PC-6 or ST-36 on gastric motility was associated with vagal activity. Laser needle can be used as an alternative stimulation therapy.

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Section: Discussionmentioning

confidence: 99%

Manual Acupuncture and Laser Acupuncture for Autonomic Regulations in Rats: Observation on Heart Rate Variability and Gastric Motility

Yang

Xin

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Two studies investigating the treatment of depression using LS,120, 121 five studies evaluating the treatment of various addictions (i.e., alcoholism and addictions to tobacco and narcotics) using ES122, 123, 124 and LS,125, 126 and four studies examining the treatment of stroke using ES127, 128, 129, 130 are shown in Table 7, Table 8, Table 9, respectively. LS was used by a research group to treat depression120, 121, whereas two studies used ES devices123, 124, one used LS 125 to treat tobacco dependence, one used an ES device in the treatment of drug abuse, 122 and one used LS to treat alcoholism 126 .…”

Section: Resultsmentioning

confidence: 99%

“…LS was used by a research group to treat depression120, 121, whereas two studies used ES devices123, 124, one used LS 125 to treat tobacco dependence, one used an ES device in the treatment of drug abuse, 122 and one used LS to treat alcoholism 126 . Five studies showed that the use of ES and that of LS for treating various addictions were appropriate treatment adjuncts.…”

Section: Resultsmentioning

confidence: 99%

Modern acupuncture-like stimulation methods: a literature review

Jun

Kim

2015

Integrative Medicine Research

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Acupuncture therapy has been proved to be effective for diverse diseases, symptoms, and conditions in numerous clinical trials. The growing popularity of acupuncture therapy has triggered the development of modern acupuncture-like stimulation devices (ASDs), which are equivalent or superior to manual acupuncture with respect to safety, decreased risk of infection, and facilitation of clinical trials. Here, we aim to summarize the research on modern ASDs, with a focus on featured devices undergoing active research and their effectiveness and target symptoms, along with annual publication rates. We searched the popular electronic databases Medline, PubMed, the Cochrane Library, and Web of Science, and analyzed English-language studies on humans. Thereby, a total of 728 studies were identified, of which 195 studies met our inclusion criteria. Electrical stimulators were found to be the earliest and most widely studied devices (133 articles), followed by laser (44 articles), magnetic (16 articles), and ultrasound (2 articles) stimulators. A total of 114 studies used randomized controlled trials, and 109 studies reported therapeutic benefits. The majority of the studies (32%) focused on analgesia and pain-relief effects, followed by effects on brain activity (16%). All types of the reviewed ASDs were associated with increasing annual publication trends; specifically, the annual growth in publications regarding noninvasive stimulation methods was more rapid than that regarding invasive methods. Based on this observation, we anticipate that the noninvasive or minimally invasive ASDs will become more popular in acupuncture therapy.

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“…Because LLLT uses a low irradiation level laser and there is no risk of excessive heat, its mechanism is believed to be associated with a photochemical effect, rather than a thermal effect [6]. Previous studies have reported that LA improves cognitive deficits and memory impairment in various neurological disorders, such as depression [25], autism [9], and Parkinson's disease [8]. …”

Section: Discussionmentioning

confidence: 99%

Laser Acupuncture Exerts Neuroprotective Effects via Regulation of Creb, Bdnf, Bcl-2, and Bax Gene Expressions in the Hippocampus

Yun

Jang

Yoon

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Acupuncture has a positive effect on cognitive deficits. However, the effects of laser acupuncture (LA) on cognitive function and its mechanisms of action are unclear. The present study aimed to evaluate the effects of LA on middle cerebral artery occlusion- (MCAO-) induced cognitive impairment and its mechanisms of action. Transient focal cerebral ischemia was modeled in adult Sprague-Dawley rats by MCAO. After LA or manual-acupuncture (MA) treatment at the GV20 and HT7 for 2 weeks, hippocampal-dependent memory was evaluated using the Morris water maze (MWM) test. The hippocampus was dissected to analyze choline acetyltransferase (ChAT) immunoreactivity and Creb, Bdnf, Bcl-2, and Bax gene expressions. MWM test demonstrated a significant improvement in hippocampal-dependent memory in the MCAO rats after LA treatment. LA treatment significantly reversed the postischemic decrease in ChAT immunoreactivity in the hippocampal CA1 region. LA treatment significantly normalized gene expression in the hippocampus which had been altered by MCAO, especially upregulating gene expression of Creb, Bdnf, and Bcl-2 and downregulating gene expression of Bax. This study suggests that LA treatment could improve cognitive impairment in MCAO rats to enhance the cholinergic system in the hippocampal CA1 region and to exert a neuroprotective effect by regulating Creb, Bdnf, Bcl-2, and Bax gene expressions.

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Laser acupuncture for depression: A randomised double blind controlled trial using low intensity laser intervention

Cited by 56 publications

References 38 publications

Manual Acupuncture and Laser Acupuncture for Autonomic Regulations in Rats: Observation on Heart Rate Variability and Gastric Motility

Manual Acupuncture and Laser Acupuncture for Autonomic Regulations in Rats: Observation on Heart Rate Variability and Gastric Motility

Modern acupuncture-like stimulation methods: a literature review

Laser Acupuncture Exerts Neuroprotective Effects via Regulation of Creb, Bdnf, Bcl-2, and Bax Gene Expressions in the Hippocampus

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