Laser-based ambient mass spectrometry

Cheng, Sy-Chyi; Shiea, Christopher; Huang, Yeou‐Lih; Wang, Chin‐Hsiung; Cho, Yi‐Tzu; Shiea, Jentaie

doi:10.1039/c7ay00997f

Cited by 35 publications

(22 citation statements)

References 122 publications

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“…Ambient ionization mass spectrometry techniques use ionization in open laboratory air to generate mass spectra of complex mixtures. Over 40 different types of ambient ionization techniques have been developed in the past decade . Some of these methods include atmospheric solids analysis probe (ASAP), direct analysis in real time (DART), desorption electrospray ionization (DESI) and extractive electrospray ionization (EESI) …”

Section: Introductionmentioning

confidence: 99%

A cautionary note on the effects of laboratory air contaminants on ambient ionization mass spectrometry measurements

Kumbhani

Wingen

Perraud

et al. 2017

Rapid Comm Mass Spectrometry

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Section: Introductionmentioning

confidence: 99%

A cautionary note on the effects of laboratory air contaminants on ambient ionization mass spectrometry measurements

Kumbhani

Wingen

Perraud

et al. 2017

Rapid Comm Mass Spectrometry

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“…[23] By increasing the voltage applied to the tube lens relative to the skimmer lens, ions can be accelerated under a pressure of ,0.2 Pa during ion transfer to the ion trap before mass analysis, which results in collision-induced dissociation (CID) in the ion source (in-source CID). By use of in-source CID, benzylammonium precursor ions lose a small [6] þ (-Cl), and [7] þ (-CN).…”

Section: Resultsmentioning

confidence: 99%

“…[1] Methods for forming ions under ambient conditions can be classified into three primary groups that are based on liquid solution sprays, [2,3] laser desorption from surfaces, [4][5][6] and plasma ionization. [7] Such ionization methods can be used to analyse samples in the open atmosphere without the need for ion source enclosure, which facilitates high-throughput screening applications, including in the analysis of pharmaceutical tablets, [8] forensic samples, [9][10][11] explosives, [12,13] narcotics, [14] chemical warfare agents, [15][16][17] and persistent organic pollutants, [18][19][20] and bacterial profiling.…”

Section: Introductionmentioning

confidence: 99%

Internal Energy Deposition in Dielectric Barrier Discharge Ionization is Significantly Lower than in Direct Analysis in Real-Time Mass Spectrometry

2017

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The extent of internal energy deposition using three different plasma-based ionization mass spectrometry (MS) methods, atmospheric pressure chemical ionization (APCI), direct analysis in real time (DART), and active capillary dielectric barrier discharge ionization (DBDI), was investigated using benzylammonium 'thermometer' ions. Ions formed by DBDI were activated significantly less than those that were formed by DART and APCI under these conditions. Thermal ion activation by DART can be reduced slightly by positioning the DART source further from the capillary entrance to the MS and reducing the heat that is applied to metastable atoms exiting the DART source. For example, the average ion internal energy distribution decreased by less than 10 % (166.9 AE 0.3 to 152.2 AE 1.0 kJ mol À1) when the distance between the DART source and the MS was increased by 250 % (10 to 25 mm). By lowering the DART temperature from 350 to 1508C, the internal energy distributions of the thermometer ions decreased by ,15 % (169.93 AE 0.83 to 150.21 AE 0.52 kJ mol À1). Positioning the DART source nozzle more than 25 mm from the entrance to the MS and decreasing the DART temperature further resulted in a significant decrease in ion signal. Thus, varying the major DART ion source parameters had minimal impact on the 'softness' of the DART ion source under these conditions. Overall, these data indicate that DBDI can be a significantly 'softer' ion source than two of the most widely used plasma-based ion sources that are commercially available.

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“…A chronology of the first publication of these LD/A‐AIMS techniques is displayed in Figure 10. Discussions about the implementation and basic mechanisms of LD/A‐AIMS can be found in a recent review by Shiea and coworkers (Cheng et al, 2017). These hyphenated techniques present mass spectral features predominantly resembling those obtained with direct AIMS, but with enhanced MS signal due to increased desorption efficiency of lowly volatile compounds.…”

Section: Laser Desorption/ablation Coupled To Ambient Ionization In Bioapplicationsmentioning

confidence: 99%

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

Ding

Liu

Shi

2020

Mass Spectrometry Reviews

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Lasers have long been used in the field of mass spectrometric analysis for characterization of condensed matter. However, emission of neutrals upon laser irradiation surpasses the number of ions. Typically, only one in about one million analytes ejected by laser desorption/ablation is ionized, which has fueled the quest for postionization methods enabling ionization of desorbed neutrals to enhance mass spectrometric detection schemes. The development of postionization techniques can be an endeavor that integrates multiple disciplines involving photon energy transfer, electrochemistry, gas discharge, etc. The combination of lasers of different parameters and diverse ion sources has made laser desorption/ablation postionization (LD/API) a growing and lively research community, including two‐step laser mass spectrometry, laser ablation atmospheric pressure photoionization mass spectrometry, and those coupled to ambient mass spectrometry. These hyphenated techniques have shown potentials in bioanalytical applications, with major inroads to be made in simultaneous location and quantification of pharmaceuticals, toxins, and metabolites in complex biomatrixes. This review is intended to provide a timely comprehensive view of the broadening bioanalytical applications of disparate LD/API techniques. We also have attempted to discuss these applications according to the classifications based on the postionization methods and to encapsulate the latest achievements in the field of LD/API by highlighting some of the very best reports in the 21st century. © 2020 John Wiley & Sons Ltd.

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Laser-based ambient mass spectrometry

Abstract: This study summarized laser-based ambient mass spectrometric (AMS) techniques with regard to their fundamentals, ionization mechanisms, and recent applications.

Cited by 35 publications

References 122 publications

A cautionary note on the effects of laboratory air contaminants on ambient ionization mass spectrometry measurements

A cautionary note on the effects of laboratory air contaminants on ambient ionization mass spectrometry measurements

Internal Energy Deposition in Dielectric Barrier Discharge Ionization is Significantly Lower than in Direct Analysis in Real-Time Mass Spectrometry

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

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