Laser desorption/ionization coupled to tandem mass spectrometry for real-time monitoring of paraquat on the surface of environmental particles

Lazar, Alexandru C.; Reilly, Peter T. A.; Whitten, William B.; Ramsey, J. Michael

doi:10.1002/1097-0231(20000830)14:16<1523::aid-rcm58>3.0.co;2-6

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…[1][2][3][4][5][6][7][8] Numerous MS studies of these organic salts using positive-mode ESI (and other soft ionization techniques) have shown formation of ions of different types: the dications (Cat 2þ ) [1][2][3][4]6,[8][9][10] and cation radicals (Cat þ. ), [1][2][3]5,7,[9][10][11][12][13][14][15] deprotonation products ([Cat-1] þ ), [1][2][3][4][5][6][7][8][10][11][12][14][15][16] cation fragments 1,3,[5][6][7][9][10][11][13]…”

mentioning

confidence: 99%

Cluster ions of diquat and paraquat in electrospray ionization mass spectra and their collision‐induced dissociation spectra

Milman

2003

Rapid Comm Mass Spectrometry

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Cluster ions such as [Cat+X+nM](+) (n = 0-4); [Cat-H+nM](+) (n = 1-3); and [2(Cat-H)+X+nM](+) (n = 0-2), where Cat, X, and M are the dication, anion, and neutral salt (CatX(2)), respectively, are observed in electrospray ionization (ESI) mass spectrometry of relatively concentrated solutions of diquat and paraquat. Collision-induced dissociation (CID) reactions of the clusters were observed by tandem mass spectrometry (MS/MS), including deprotonation to form [Cat-H](+), one-electron reduction of the dication to form Cat(+.), demethylation of the paraquat cation to form [Cat-CH(3)](+), and loss of neutral salt to produce smaller clusters. The difference in acidity and reduction power between diquat and paraquat, evaluated by thermodynamical estimates, can rationalize the different fractional yields of even-electron ([Cat-H](+) and its clusters) and odd-electron (mostly Cat(+)) ions in ESI mass spectra of these pesticides. The [Cat+n. Solv](2+) doubly charged cluster ions, where n

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confidence: 99%

Cluster ions of diquat and paraquat in electrospray ionization mass spectra and their collision‐induced dissociation spectra

Milman

2003

Rapid Comm Mass Spectrometry

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“…Single-particle analysis provides such a technique. The use of mass spectrometry to identify the insecticide paraquat on particles was explored by Lazar et al 30 This study reported the average spectra for multiple coated particles with detection limits of less than a monolayer. These results suggest that the analysis of single particles may be a useful tool for analyzing the spread of organic contaminants by determining the complete chemical composition of individual pesticide-containing particles.…”

Section: Resultsmentioning

confidence: 99%

Detection of Pesticide Residues on Individual Particles

Whiteaker

Prather

2002

Anal. Chem.

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An aerosol time-of-flight mass spectrometer (ATOFMS) is used to analyze the size and composition of individual particles containing pesticides. Pesticide residues are found in the atmosphere as a result of spray drift, volatilization, and suspension of coated soils. The ability of the ATOFMS to identify the presence of these contaminants on individual particles is assessed for particles created from pure solutions of several commonly used pesticides, as well as pesticides mixed with an organic matrix, and coated on soils. The common names of the pesticides studied are 2,4-D, atrazine, chlorpyrifos, malathion, permethrin, and propoxur. Analysis of the mass spectra produced by single- and two-step laser desorption/ionization of pesticide-containing particles allows for identification of peaks that can be used for detection of pesticide residues in the ambient aerosol. The identified marker peaks are used to approximate detection limits for the pesticides applied to soils, which are on the order of a fraction of a monolayer for individual particles. Results suggest that this technique may be useful for studying the real-time partitioning and distribution of pesticides in the atmosphere immediately following application in agricultural regions.

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“…This ion trap has also shown the ability to levitate intact particles prior to the LDI event (Yang et al, 1995a). Direct atmospheric sampling of particles into an ion trap was also reported with ionization via a XeCl Excimer laser at 308 nm, along with tandem MS (Reilly et al, 1997;Gieray et al, 1998;Lazar et al, 2000). More recently, a field transportable single particle ion trap was reported capable of tandem MS on individual ambient aerosol particles (Harris et al, 2005b).…”

Section: Laser Desorption/ionization (Ldi) Ion Trapsmentioning

confidence: 99%

“…Several ion trap configurations have been coupled to LDI of single particles (Dale et al, 1994;Yang et al, 1995a,b;Reilly et al, 1997;Gieray et al, 1998;Hong et al, 1999;Lazar et al, 2000;Harris, Reilly, & Whitten, 2006). Ramsey and co-workers FIGURE 1.…”

Section: Laser Desorption/ionization (Ldi) Ion Trapsmentioning

confidence: 99%

Microorganism characterization by single particle mass spectrometry

Russell

2008

Mass Spectrometry Reviews

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In recent years a major effort by several groups has been undertaken to identify bacteria by mass spectrometry at the single cell level. The intent of this review is to highlight the recent progress made in the application of single particle mass spectrometry to the analysis of microorganisms. A large portion of the review highlights improvements in the ionization and mass analysis of bio-aerosols, or particles that contain biologically relevant molecules such as peptides or proteins. While these are not direct applications to bacteria, the results have been central to a progression toward single cell mass spectrometry. Developments in single particle matrix-assisted laser desorption/ionization (MALDI) are summarized. Recent applications of aerosol laser desorption/ionization (LDI) to the analysis of single microorganisms are highlighted. Successful applications of off-line and on-the-fly aerosol MALDI to microorganism detection are discussed. Limitations to current approaches and necessary future achievements are also addressed.

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Laser desorption/ionization coupled to tandem mass spectrometry for real-time monitoring of paraquat on the surface of environmental particles

Cited by 13 publications

References 29 publications

Cluster ions of diquat and paraquat in electrospray ionization mass spectra and their collision‐induced dissociation spectra

Cluster ions of diquat and paraquat in electrospray ionization mass spectra and their collision‐induced dissociation spectra

Detection of Pesticide Residues on Individual Particles

Microorganism characterization by single particle mass spectrometry

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