Laser Doppler Perfusion Imaging: A New Technique for Measuring Skin Blood Flow in Rheumatology

Seifalian, AM; Howell, Kevin; Stansby, Gerard; Jackson, A; Hamilton, George; Black, Carol M.

doi:10.1093/rheumatology/32.10.938

Cited by 14 publications

(5 citation statements)

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“…The main difference between them is that LDPM uses optical fibers to carry the light to and from the tissue, while LPDI uses a scanning method with a distant light source and detector 9,[29][30][31] . Previous studies have shown that LDPI is able to detect changes in SSc microvasculature, particularly when combined with NVC and thermal infrared imaging 13,32,33 . In addition, LDPI has been employed in a small group of patients to evaluate skin blood flow in secondary RP, hand-arm vibration syndrome, and morphea plaques [15][16][17] .…”

Section: Discussionmentioning

confidence: 99%

Laser Doppler Perfusion Imaging Is Useful in the Study of Raynaud’s Phenomenon and Improves the Capillaroscopic Diagnosis

Rosato¹,

Borghese²,

Pisarri³

et al. 2009

J Rheumatol

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Section: Discussionmentioning

confidence: 99%

Laser Doppler Perfusion Imaging Is Useful in the Study of Raynaud’s Phenomenon and Improves the Capillaroscopic Diagnosis

Rosato¹,

Borghese²,

Pisarri³

et al. 2009

J Rheumatol

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“…of skin perfusion without touching the surface (9). Most studies using LDI have been concerned with quantifying the reaction from irritants (10)(11)(12), measuring the changes of microcirculation of tissues (13,14), and assessing patch tests (15). Use of LDI in the study of photodermatology, however, was lacking.…”

Section: Abstract: Ldi (Laser Doppler Perfusion Imaging); Blood Flowmentioning

confidence: 99%

Comparative quantitative analysis of ultraviolet B‐induced skin blood flow change using laser Doppler perfusion imaging technique

Youn

Park

et al. 2000

Photoderm Photoimm Photomed

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Laser Doppler perfusion imaging (LDI), recently developed, can generate a color-coded image of tissue perfusion, making it possible to assess the spatial distribution of skin perfusion without touching the surface. Using this apparatus, we investigated ultraviolet B (UVB)-induced perfusion profile of the skin and compared the results with those obtained from laser Doppler flowmetry (LDF). Fifteen adult male Korean volunteers were irradiated with several doses of UVB ranging from 25 mJ/cm2 to 186 mJ/cm2. Twenty-four hours later, the erythema reaction was evaluated with LDF and LDI systems. There was a significant correlation between the logarithmic dose of UVB and erythema values. The curves consisted of two parts, an initial, flat phase and then a linear, steep one. Also, there was a good correlation between LDF and LDI. The LDI is as sensitive as conventional LDF, but has the many advantages of measuring blood flow over large areas without contact with the skin surface. This instrument will be useful in the measurement of skin blood flow in many areas of dermatological application.

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“…Cutaneous microcirculation contains only about 5% of the total skin blood flow but is essential to fulfill vital functions, of which tissue nutrition is the most important. Measurement of the cutaneous microcirculation using laser Doppler technology is being applied to many areas of clinical medicine, such as peripheral vascular disease (2) , rheumatology (3,4) , wound healing of skin flaps (5) , breast cancer (6)(7)(8) , and assessment of organ transplantation (9)(10)(11) . This perfusion parameter can measure the severity of the clinical problem, monitor the progress of individual patients, and determine the value of treatment, including failure of treatment before clinical observation.…”

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confidence: 99%

A new technique to map vulva microcirculation using laser Doppler perfusion imager

Saravanamuthu

Seifalian

Reid

et al. 2003

Int J Gynecol Cancer

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The location of the vulva has had limited technologic progress in the assessment of the skin microcirculation and its application to clinical practice. Our group previously demonstrated increased perfusion in vulvar cancer compared to adjacent uninvolved skin with the laser Doppler flowmetry (LDF). The LDF is severely limited by its low spatial resolution (∼1 mm2) and pressure involved in positioning of the probe, which may affect value of the underlying tissue perfusion. Topographic perfusion mapping of the whole vulvar skin using LDF is also time consuming and is not clinically practical. We describe for the first time the application of the novel laser Doppler perfusion imager (LDPI) to map vulvar skin blood flow and give example in two cases with well-defined vulvar pathology—psoriasis and lichen sclerosus with invasive neoplasia—and discuss the potential of LDPI to study vulvar skin blood flow.

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Laser Doppler Perfusion Imaging: A New Technique for Measuring Skin Blood Flow in Rheumatology

Cited by 14 publications

References 0 publications

Laser Doppler Perfusion Imaging Is Useful in the Study of Raynaud’s Phenomenon and Improves the Capillaroscopic Diagnosis

Laser Doppler Perfusion Imaging Is Useful in the Study of Raynaud’s Phenomenon and Improves the Capillaroscopic Diagnosis

Comparative quantitative analysis of ultraviolet B‐induced skin blood flow change using laser Doppler perfusion imaging technique

A new technique to map vulva microcirculation using laser Doppler perfusion imager

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