Laser Doppler Velocimetry Study of Retinal Circulation in Diabetes Mellitus

Grunwald, Juan E.; Riva, Charles E.; Sinclair, Stephen H.; Brucker, Alexander J.; Petrig, Benno L.

doi:10.1001/archopht.1986.01050190049038

Cited by 202 publications

(99 citation statements)

References 23 publications

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“…However, the nature of the blood flow alteration is far from conclusive, even when only considering data published by the same authors. Grunwald et al (30) found no significant changes in retinal blood flow in any of his untreated diabetic groups. Others, using fluorescein angiographic techniques, have found a decrease in retinal blood flow in patients with diabetes and no retinopathy at the level of the arterioles (14) and capillaries (50).…”

Section: Discussionmentioning

confidence: 87%

Retinal Hemodynamics in Early Diabetic Macular Edema

et al. 2006

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The objective of this study was to establish the baseline retinal hemodynamic characteristics of stratified groups of diabetic patients at increasing risk for the development of diabetic macular edema (DME). Group 1 had 50 control subjects, group 2 had 56 diabetic patients without clinically visible retinopathy, group 3 had 54 diabetic patients with microaneurysms and/or hard exudates within two disc diameters of the fovea in the absence of clinically manifest DME, and group 4 had 40 patients with clinically manifest DME. Retinal hemodynamics (diameter, velocity, maximum-to-minimum velocity ratio, and flow) were assessed. Intraocular pressure, blood pressure, and relevant systemic markers of diabetes control and complications were also undertaken. The maximum-to-minimum velocity ratio was elevated with increasing risk of clinically significant DME (P < 0.0001). No significant differences were found between the groups with respect to diameter, velocity, or flow. The maximum-to-minimum velocity ratio was correlated to age, duration of diabetes, blood pressure, pulse rate, intraocular pressure, and serum potassium levels. In conclusion, the maximum-to-minimum velocity ratio was significantly increased with increasing risk of development of DME. Retinal arteriolar hemodynamics were positively correlated to age, duration of diabetes, and blood pressure. These findings suggest a reduction in the compliance (i.e., an increase of vascular rigidity) of the arteriolar circulation with increasing risk of DME. Diabetes 55:813-818, 2006

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Section: Discussionmentioning

confidence: 87%

Retinal Hemodynamics in Early Diabetic Macular Edema

et al. 2006

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“…It has been shown by numerous investigators that patients with diabetic retinopathy have increased venous and arterial vessel diameters [92±97]. Blood velocities in retinal veins considerably decrease, however, with progression of diabetic retinopathy [93]. As total blood flow is dependent on the cross-sectional area of the vessel as well as on flow velocity the authors did not find any alterations in total retinal blood flow.…”

Section: Discussionmentioning

confidence: 89%

Ocular blood flow and associated functional deviations in diabetic retinopathy

1999

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“…There have also been conflicting reports of impaired hemodynamics in the orbital vessels in patients with DR [3][4][5][6][7][8][9][10][11][12][13][14]. Orbital blood flow velocities were increased in some studies [3], but decreased in others [4, 9-11, 13, 14], or unchanged [15].…”

Section: Introductionmentioning

confidence: 99%

Orbital Doppler Evaluation of Blood Flow Velocities in Patients with Diabetic Retinopathy

Karami

Janghorbani²,

Dehghani³

et al. 2012

Rev Diabet Stud

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■ Abstract BACKGROUND:There have been conflicting results in relation to impaired ocular hemodynamics in the orbital vessels of patients with diabetic retinopathy (DR). Clarification of the early signs of retinopathy in diabetic patients is urgently needed. AIMS: We aimed to evaluate orbital blood flow velocities using Doppler and gray-scale sonography in patients with DR, and to compare the results with those of their non-diabetic and diabetic peers without retinopathy. METHODS: Orbital Doppler and gray-scale sonography were performed in 123 patients aged 29-77 who had been divided into 3 groups: non-diabetic controls (n = 25), diabetes and impaired glucose tolerance with minimal clinical retinopathy (n = 74), and diabetes with untreated nonproliferative retinopathy (n = 24). Retinopathy was diagnosed by an ophthalmologist on the basis of fundoscopic examination. The peak systolic (PSV) and end-diastolic (EDV) blood flow velocities, and the resistivity and pulsatile indices, of the ophthalmic artery, central retinal artery, posterior ciliary artery, and central retinal vein were measured. RE-SULTS: Compared with healthy controls, the age-adjusted resistivity and pulsatile indices of the ophthalmic artery were significantly higher in patients with DR (p < 0.05). PSV and EDV of the posterior ciliary arteries were significantly lower in diabetic patients with DR. After further adjustment for age, gender, HbA1c, fasting plasma glucose, blood pressure, BMI, cholesterol, HDL, LDL, and triglycerides, only the resistivity index of the ophthalmic artery and the central retinal vein remained significantly higher in patients with DR compared with healthy controls (p < 0.005 after Bonferroni adjustment). CONCLUSIONS: Resistivity index alteration of the ophthalmic artery and central retinal vein may be prevalent among patients with early changes in DR.

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Laser Doppler Velocimetry Study of Retinal Circulation in Diabetes Mellitus

Cited by 202 publications

References 23 publications

Retinal Hemodynamics in Early Diabetic Macular Edema

Retinal Hemodynamics in Early Diabetic Macular Edema

Ocular blood flow and associated functional deviations in diabetic retinopathy

Orbital Doppler Evaluation of Blood Flow Velocities in Patients with Diabetic Retinopathy

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