Laser Immunonephelometry Reference Intervals for Eight Serum Proteins in Healthy Children

et al. 1999

range, in close agreement with ours where selection was based upon reported diagnosis rather than upon determination of individual health status. This meta-analysis provides support for the reliability of our recently published methodology and reference data for the clinical interpretation of individual albumin, transferrin, and transthyretin values. As with most laboratory measurements, clinical interpretation requires that other laboratory and clinical factors be considered.

“…Two studies did not include age (8,18). The remaining 15 studies (5)(6)(7)28,42,46,49,52,56,61,69,70,73,83,101) were considered acceptable for transthyretin measurements.…”

Section: Number Of Studies Available For Analysismentioning

confidence: 99%

Reference distributions for the negative acute-phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature

et al. 1999

“…Of the 30 studies included in these analyses, 11 (11,13,22,26,37,41,45,52,53,56,63) did not provide racial or ethnic information, 16 were mainly Caucasian (4)(5)(6)14,21,(23)(24)(25)(30)(31)(32)36,40,51,57,58), one consisted mainly of black Africans (48), and two consisted of Asians (19,20). There was insufficient data to determine whether racial or ethnic differences exist.…”

Section: Ethnic Group-specific Reference Rangesmentioning

confidence: 99%

“…The remaining 16 studies (4-6,13,14,19,21,23,24,30-32,36,48,51,57) provided acceptable central estimates. Of these, 12 also provided acceptable reference ranges(4)(5)(6)19,21,24,(30)(31)(32)36,48,51).…”

mentioning

confidence: 97%

Reference distributions for the positive acute phase proteins, α1‐acid glycoprotein (orosomucoid), α1‐antitrypsin, and haptoglobin: A comparison of a large cohort to the world’s literature

et al. 2000

Limiting bedside use of positive acute phase protein measurements (alpha1-acid glycoprotein (orosomucoid), alpha1-antitrypsin, and haptoglobin) has been the lack of satisfactory methods for quantifying serum levels and a credible reference material. Great strides have been made in the last few years. The remaining barrier to more relevant and cost-effective use of serum protein data for diagnosis and prognosis is the availability of reliable reference intervals from birth to old age for both males and females. Sixty publications reporting reference intervals have been identified which meet the criteria used in our prior two studies, and these have been analyzed statistically. Previous small studies of these individual proteins agree on average, over their constrained age ranges, with our life-long reference ranges. This meta-analysis provides support for our reference ranges and places them in the perspective of previous publications.

“…A total of 34 publications were identified that contained information on α 1 -acid glycoprotein in apparently healthy individuals (4)(5)(6)(13)(14)(15)(16)(17)(18)(19)21,23,24,(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)43,44,47,48,51,55,57,(59)(60)(61)(62). Eleven studies did not include adequate data on either reference material or assay methodology (18,28,34,35,44,47,55,(59)(60)(61)(62).…”

Section: Number Of Studies Available For Analysismentioning

confidence: 99%

Section: Ethnic Group-specific Reference Rangesmentioning

confidence: 99%

Reference distributions for the positive acute phase proteins, ?1-acid glycoprotein (orosomucoid), ?1-antitrypsin, and haptoglobin: A comparison of a large cohort to the world?s literature

et al. 2000

Limiting bedside use of positive acute phase protein measurements (α1‐acid glycoprotein (orosomucoid), α1‐antitrypsin, and haptoglobin) has been the lack of satisfactory methods for quantifying serum levels and a credible reference material. Great strides have been made in the last few years. The remaining barrier to more relevant and cost‐effective use of serum protein data for diagnosis and prognosis is the availability of reliable reference intervals from birth to old age for both males and females. Sixty publications reporting reference intervals have been identified which meet the criteria used in our prior two studies, and these have been analyzed statistically. Previous small studies of these individual proteins agree on average, over their constrained age ranges, with our life‐long reference ranges. This meta‐analysis provides support for our reference ranges and places them in the perspective of previous publications. J. Clin. Lab. Anal. 14:265–270, 2000. © 2000 Wiley‐Liss, Inc.