Laser in situ keratomileusis for astigmatism ≤ 0.75 Diopter combined with low myopia: a retrospective data analysis

Katz, Toam; Фрингс, Андреас; Linke, Stephan J.; Richard, Gisbert; Druchkiv, Vasyl; Steinberg, Johannes

doi:10.1186/1471-2415-14-1

Cited by 44 publications

(37 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of vector-based predictability, this study had a tendency to overcorrect the cylinder less than -0.50 D. There were similar results in the previous studies for the LASIK procedure [ 24 , 25 ]. Undercorrection was observed as the cylinder increased, which was inconsistent with the results of MofE, CI and IOS in the present study.…”

Section: Discussionsupporting

confidence: 86%

Vector analysis of low to moderate astigmatism with small incision lenticule extraction (SMILE): results of a 1-year follow-up

Zhang

Wang

et al. 2015

BMC Ophthalmol

View full text Add to dashboard Cite

BackgroundTo evaluate the refractive outcomes for the correction of low to moderate astigmatism up to 1 year following small incision lenticule extraction (SMILE) surgery.MethodsThis retrospective study enrolled 98 eyes from 98 patients who underwent SMILE surgery for the correction of myopia and astigmatism. Only right eyes were included in this study to avoid the bias of orientation errors. The vector method was used to analyze the outcomes of astigmatism at 1 month, 6 months and 12 months after the procedure, including the double-angle plots, correction index (CI), index of success (IOS), angle of error (AofE) and magnitude of error (MofE). The effectiveness, safety, stability and predictability were also investigated during the 12-month follow-up.ResultsThe preoperative cylinder ranged from -2.75 D to -0.25 D (average of -0.90 ± 0.68 D), and the mean postoperative cylinder values were -0.24 ± 0.29 D, -0.24 ± 0.29 D, and -0.20 ± 0.27 D at 1 month, 6 months, and 12 months, respectively. The mean astigmatism in vector form was -0.14 D × 27.19° at 1 month, -0.13 D × 27.29° at 6 months, and -0.10 D × 28.63° at 12 months after surgery. The CI was 1.00 ± 0.32 and IOS was 0.29 ± 0.44 at the 12-month follow-up. Significant negative correlations were found between the CI and absolute target induced astigmatism (TIA) value, and positive correlations were found between the IOS and absolute AofE value (P < 0.05). The MofE was limited within ±1.00 D at the 12-month follow-up. Fifty-six eyes (57.1%) gained one line in corrected distance visual acuity (CDVA) and five eyes (5.1%) gained two lines. There were no significant differences observed in the refractive outcomes among time points.ConclusionsSMILE surgery was effective and safe in correcting low to moderate astigmatism, and stable refractive outcomes were observed at the long-term follow-up. The undercorrection of astigmatism could possibly be influenced by attempted astigmatism correction preoperatively, the axis rotation during the surgery or wound healing postoperatively. This study suggested that nomograms should be adjusted in correcting astigmatism with SMILE surgery.

show abstract

Section: Discussionsupporting

confidence: 86%

Vector analysis of low to moderate astigmatism with small incision lenticule extraction (SMILE): results of a 1-year follow-up

Zhang

Wang

et al. 2015

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Previous studies have advised caution with full astigmatic correction employing WFO-LASIK in eyes with preoperative cylinder 0.5 D or less. 30,31 Although dividing our data into subgroups demonstrated a trend toward increased angle of error in the eyes with low preoperative astigmatism, this did not reach statistical significance. We also found that both WFO-LASIK and WFG-LASIK did induce de novo astigmatism in several patients.…”

Section: Discussionmentioning

confidence: 55%

Vector Analysis of 1-Year Astigmatic Outcomes From a Prospective, Randomized, Fellow Eye Comparison of Wavefront-Guided and Wavefront-Optimized LASIK in Myopes

Toy¹,

Yu²,

Manche³

2015

J Refract Surg

View full text Add to dashboard Cite

show abstract

“…Cataracts are one of the common causes of visual impairment in diabetic subjects [1, 2]. In patients with diabetes, cataract has an early onset and develops 2 to 5 times more frequently [3–5].…”

Section: Introductionmentioning

confidence: 99%

Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats

et al. 2017

View full text Add to dashboard Cite

Cataract, a leading cause of blindness, is of special concern in diabetics as it occurs at earlier onset. Polyol accumulation and increased oxidative-nitrosative stress in cataractogenesis are associated with NFκB activation, iNOS expression, ATP depletion, loss of ATPase functions, calpain activation and proteolysis of soluble to insoluble proteins. Tocotrienol was previously shown to reduce lens oxidative stress and inhibit cataractogenesis in galactose-fed rats. In current study, we investigated anticataract effects of topical tocotrienol and possible mechanisms involved in streptozotocin-induced diabetic rats. Diabetes was induced in Sprague Dawley rats by intraperitoneal injection of streptozotocin. Diabetic rats were treated with vehicle (DV) or tocotrienol (DT). A third group consists of normal, non-diabetic rats were treated with vehicle (NV). All treatments were given topically, bilaterally, twice daily for 8 weeks with weekly slit lamp monitoring. Subsequently, rats were euthanized and lenses were subjected to estimation of polyol accumulation, oxidative-nitrosative stress, NFκB activation, iNOS expression, ATP levels, ATPase activities, calpain activity and total protein levels. Cataract progression was delayed from the fifth week onwards in DT with lower mean of cataract stages compared to DV group (p<0.01) despite persistent hyperglycemia. Reduced cataractogenesis in DT group was accompanied with lower aldose reductase activity and sorbitol level compared to DV group (p<0.01). DT group also showed reduced NFκB activation, lower iNOS expression and reduced oxidative-nitrosative stress compared to DV group. Lenticular ATP and ATPase and calpain 2 activities in DT group were restored to normal. Consequently, soluble to insoluble protein ratio in DT group was higher compared to DV (p<0.05). In conclusion, preventive effect of topical tocotrienol on development of cataract in STZ-induced diabetic rats could be attributed to reduced lens aldose reductase activity, polyol levels and oxidative-nitrosative stress. These effects of tocotrienol invlove reduced NFκB activation, lower iNOS expression, restoration of ATP level, ATPase activities, calpain activity and lens protein levels.

show abstract

Laser in situ keratomileusis for astigmatism ≤ 0.75 Diopter combined with low myopia: a retrospective data analysis

Cited by 44 publications

References 17 publications

Vector analysis of low to moderate astigmatism with small incision lenticule extraction (SMILE): results of a 1-year follow-up

Vector analysis of low to moderate astigmatism with small incision lenticule extraction (SMILE): results of a 1-year follow-up

Vector Analysis of 1-Year Astigmatic Outcomes From a Prospective, Randomized, Fellow Eye Comparison of Wavefront-Guided and Wavefront-Optimized LASIK in Myopes

Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats

Contact Info

Product

Resources

About