Laser ionization mass spectrometry in oral squamous cell carcinoma

Saraswathy, Seema; Krishnan, Manu; Harith, Arun Kumar; Sahai, Kavita; Iyer, Satish R.; Arora, Vimal; Tripathi, R. P.

doi:10.1111/jop.12117

Cited by 11 publications

(11 citation statements)

References 97 publications

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“…Therefore, a single biomarker is probably insufficient to diagnose head and neck cancer and a biomarker panel of genes is recommended. It might also be unclear which post-transcriptional regulatory processes are involved (70). Table 1 and Supplementary Table 1 summarize the biomarkers involving genomics.…”

Section: Genomicsmentioning

confidence: 99%

A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms

et al. 2020

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Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of biomarkers, covering the different-omics fields to diagnose head and neck neoplasms in the early phase. To date, not a single biomarker, nor a panel of biomarkers for the detection of head and neck tumors has been detected with clinical applicability. Limitations for the clinical implementation of the investigated biomarkers are mainly the heterogeneity of the study groups (e.g., small population in which the biomarker was tested, and/or only including high-risk populations) and a low sensitivity and/or specificity of the biomarkers under study. Further research on biomarkers to diagnose head and neck neoplasms in an early stage, is therefore needed.

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Section: Genomicsmentioning

confidence: 99%

A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms

et al. 2020

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“…The early diagnosis provides a survival rate of 80% in 5 years, while the late-stage diagnosis decreases this rate to only 20% 24 . Despite recent advances in the oncological treatment, the prognosis of patients is still controversial, mainly due to the advanced stage of the tumor at the time of diagnosis 25,26 .…”

Section: Lip and Oral Cavity Tumorsmentioning

confidence: 99%

Epidemiological profile of oral squamous cell carcinoma in a Northeastern Brazilian state

França¹,

Silva²,

Silva³

et al. 2018

Arch. Head Neck Surg.

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Introduction: Oral squamous cell carcinoma (OSCC) is considered the 6 th most frequent worldwide type of cancer. Epidemiological surveys of cancer are important to understand how its distribution occurs in population, to create public policy of prevention and improvement of reference centers for treatment of this disease. Objective: To analyze the OSCC prevalence in Alagoas and draw the patients' clinical profile providing guiding data to health professionals according to profile of the lesion. Materials and Methods: A retrospective analysis of 341 medical charts of patients diagnosed with OSCC was performed at reference hospital for cancer treatment in Alagoas. Results: Out of 341 patients analyzed, 217 (63.6%) were men and 124 (36.4%) were women. The mean age for men was 59.86 years and 63.16 years for women. There was a predominance of individuals who did not complete the elementary school (62.8%). The tongue was the most affected by OSCC. The majority of lesion was in clinical stage III. So, the first therapeutic scheme of choice was the association of radiotherapy and chemotherapy. Conclusion: Low educational level and poor socioeconomic development rates show that individuals affected by OSCC are probably more vulnerable to etiological agents often related to its occurrence.

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“…Oral squamous cell carcinoma is one of the most common types of cancer worldwide . Although different kinds of methods such as surgery, chemotherapy, and radiation have been used widely for treating oral cancer patients, diagnosis of oral cancer at early stage offers 80% survival rates, while diagnosis at late stage lessens it to 20% . Therefore, the identification of biomarkers for early detection, response to treatment, and prognosis are important goals for oral cancer therapies.…”

Section: Introductionmentioning

confidence: 99%

“…The proteomic analysis between normal and tumour tissues is used for the identification of cancer‐related proteins; and it might aid in the development of new molecular‐based target therapies. Based on the proteomic approach, alterations to a number of proteins were identified in human head and neck cancer . However, there is less evidence to show that Warburg effect‐related proteins, which act on the important cellular functions of energy metabolism, link mitochondrial dysfunction to oral tumourigenesis.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of oral cancer reveals new potential therapeutic targets involved in the Warburg effect

Huang

Chang

2017

Clin Exp Pharma Physio

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Activation of peroxisome proliferator-activated receptor alpha (PPARα) has been reported to disrupt tumour metabolism and to promote anticancer activity through interfering with the Warburg effect. This study is to investigate whether Warburg effect-related proteins also could be identified in oral tumour lesions and to explore the functional significance of PPARα in metabolic shift. Five pairs of tongue tumour tissues and adjacent reference tissues obtained from 4-NQO/arecoline induced mouse model were analyzed by 2-d-gel-electrophoresis and LC-MS. Further, the hexokinase II level, pyruvate dehydrogenase (PDH) activity, and metabolites of glycolysis and TCA cycle were all examined in order to validate the effect of PPARα on metabolic shift. Changes in protein expression levels revealed that seven proteins, which were involved in glycolysis, the tricarboxylic acid cycle, and the respiratory chain, were down-regulated in tumour tissues. We found that activation of PPARα through fenofibrate could inhibit oral cancer cell growth and switch the way of energy production from the Warburg effect to oxidative phosphorylation. Fenofibrate induced a reduction of hexokinase II protein levels, increases in PDH activity and metabolites of the TCA cycle, and an impairment of ATP production. These findings suggested that activation of the PPARα to reprogram the metabolic pathway might impair the Warburg effect and trigger cancer cell death. The study provides a novel view of changes in protein expression profiles involved in the Warburg effect during oral tumourigenesis. Activation of the PPARα to impair the Warburg effect might offer a new strategy for oral cancer treatment.

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Laser ionization mass spectrometry in oral squamous cell carcinoma

Cited by 11 publications

References 97 publications

A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms

A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms

Epidemiological profile of oral squamous cell carcinoma in a Northeastern Brazilian state

Proteomic analysis of oral cancer reveals new potential therapeutic targets involved in the Warburg effect

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