2018
DOI: 10.3390/polym10121337
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Laser Surface Microstructuring of a Bio-Resorbable Polymer to Anchor Stem Cells, Control Adipocyte Morphology, and Promote Osteogenesis

Abstract: New strategies in regenerative medicine include the implantation of stem cells cultured in bio-resorbable polymeric scaffolds to restore the tissue function and be absorbed by the body after wound healing. This requires the development of appropriate micro-technologies for manufacturing of functional scaffolds with controlled surface properties to induce a specific cell behavior. The present report focuses on the effect of substrate topography on the behavior of human mesenchymal stem cells (MSCs) before and a… Show more

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Cited by 24 publications
(27 citation statements)
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“…Its main advantage over other treatments is that it modifies the surface selectively, without destroying the material or producing toxic substances. The studies published so far address the influence of various types of laser treatment (using CO 2 , picosecond, excimer lasers) on the surface of various polymers: polycaprolactone, [ 49 , 50 ] polymethylsiloxane [ 51 ], polyethylene terephthalate [ 52 , 53 ], poly-L-lactic-acid [ 54 , 55 ], poly(L-lactide-co-glycolide) [ 56 ], chitosan, and chitosan/ceramics composites [ 57 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Its main advantage over other treatments is that it modifies the surface selectively, without destroying the material or producing toxic substances. The studies published so far address the influence of various types of laser treatment (using CO 2 , picosecond, excimer lasers) on the surface of various polymers: polycaprolactone, [ 49 , 50 ] polymethylsiloxane [ 51 ], polyethylene terephthalate [ 52 , 53 ], poly-L-lactic-acid [ 54 , 55 ], poly(L-lactide-co-glycolide) [ 56 ], chitosan, and chitosan/ceramics composites [ 57 ].…”
Section: Introductionmentioning
confidence: 99%
“…Analysis of the most recent published studies, including a thorough review by Professor Ravi-Kumar et al [ 58 ], key experimental works [ 28 , 48 , 54 , 55 ], and the latest studies [ 56 , 57 , 58 , 59 , 61 , 62 ] has provided the basis for summarizing the currently available data and existing notions of the effects produced by laser treatment of polymer materials. Laser ablation is widely used today to treat various materials (metals, ceramics, glass, and polymers).…”
Section: Introductionmentioning
confidence: 99%
“…To obtain a better and faster healing, researchers have introduced the polymeric materials capable of offering support, but also of being seeded with stem cells (Liu et al, 2013). For osteoporosis, natural materials such as green tea can be used for differentiation and guidance of bone marrow thus decreasing the bone resorption (Ortiz et al, 2018). Laser surface micro structuring is a method that, according to some recent studies, can promote osteogenesis by modifying the surface topography of a biomaterial which includes stem cells.…”
Section: Hard Tissue Engineeringmentioning
confidence: 99%
“…Laser surface micro structuring is a method that, according to some recent studies, can promote osteogenesis by modifying the surface topography of a biomaterial which includes stem cells. Pores, grooves or pits can induce the transformation of mesenchymal stem cells into a tissue with specific properties (Béduer et al, 2012, Khang et al, 2012, Ortiz et al, 2018.…”
Section: Hard Tissue Engineeringmentioning
confidence: 99%
“…Laser ablation by CO2 and short-pulsed (nanoseconds) lasers has been applied before on polyhydroxy butyrate (P3HB) to cut the material or modify its surface or bulk properties [14][15][16][17][18]. However, ultrashort pulsed lasers (in the picosecond and the femtosecond range) allow to generate surface microfeatures with higher precision and minimal thermal and chemical impact on biodegradable and biocompatible polymers [19,20]. Here, the response of novel blends of short-chain length (scl-) and medium-chain length (mcl-) PHAs to ps pulsed laser ablation at wavelengths of 355 and 532 nm is reported for the first time.…”
Section: Introductionmentioning
confidence: 99%