Laser tissue welding: A comprehensive review of current and future

Bass, Lawrence S.; Treat, Michael R.

doi:10.1002/lsm.1900170402

Cited by 274 publications

(227 citation statements)

References 131 publications

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“…The clot is typically composed of a material able to be resorbed in vivo. Solders developed have included various proteins such as BSA [190], fibrinogen [191] and purified collagen [192]. The first albumin solder was successfully developed and used to seal tissue against fluid leakage in urethral reconstruction [193].…”

Section: Laser Solderingmentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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Section: Laser Solderingmentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…Laser-mediated tissue welding is an interesting alternative for wound closure and has attracted scientific attention over the past decades [14]. It offers several advantages over common suture anastomosis including faster healing with less inflammation, precise application, and shorter procedure times [15].…”

Section: Introductionmentioning

confidence: 99%

“…The weld offers an immediate tensile strength and watertight tissue fusion with minimal damage to adjacent tissue and elimination of foreign body reaction as provoked by sutures or clips [14].…”

Section: Introductionmentioning

confidence: 99%

Laser‐mediated fixation of collagen‐based scaffolds to dermal wounds

et al. 2010

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Background and Objective: Collagen scaffolds are popular for the reconstitution of dermal equivalents. Usually, these scaffolds are fixed with sutures or staples and in many cases these devices have to be removed in a second procedure. Laser-mediated tissue welding in a wet environment is a potential alternative for collagen scaffold fixation and may be advantageous to suture, staple, and tissue glue fixation. Materials and Methods: Welding was performed with a continuous-wave diode laser system emitting radiation at a wavelength of 968 nm. Tensile strength after fixation to porcine skin and laser parameters were determined in vitro. In vivo, 24 excisional deep partial thickness wounds were created on flanks of two Goettingen mini pigs and covered with collagen scaffolds. These were randomized and fixated with either (1) staples, (2) fibrin glue, or (3) laser-mediated welding. Tissue biopsies for histological analysis were periodically performed and analyzed for wound healing progression, epidermal thickness, and extracellular matrix formation. Results: Biomechanical stability after laser welding was time dependent. A dwell time of up to 10 seconds led to a strong bonding with a tensile strength of more than 30 g. In vivo, the wound healing process was macroscopically comparable in all groups and showed no significant differences. Microscopic analysis determined a more progressed and quicker wound closure in both the laser and staples group compared to the fibrin glue fixated scaffold. Laser-mediated fixation led to a significantly reduced epidermal thickness when compared with stapling or fibrin glue (P < 0.05). Conclusions: Laser tissue welding is a feasible approach for temporary fixation of collagen scaffolds to the wound bed. It improves wound healing properties and may lead to faster wound healing and cosmetically better scarring. Laser tissue welding is thus a very interesting and promising alternative to currently established fixation methods in a single step, no touch procedure

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“…The absolute value of the coagulation temperature depends on the tissue type, the exposure time and equals 65-95°C (for human tissues) [6].…”

Section: Introductionmentioning

confidence: 99%

Procedures of optical control dedicated for laser welding process of biological tissues

Zając

Podniesiński

Świderski

et al. 2010

Opto-Electronics Review

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In this contribution, an optical method of controlling the state of soft biological tissues in real time exposed to laser radiation is discussed. The method is based on the assumption that the change dynamics of the amplitude of the scattered diagnostic radiation (λ = 635 nm) is compatible with the change dynamics of the tissue inner structure exposed to the Nd:YAG laser radiation (λ = 1064 nm). In this method, the measurement of the tissue temperature is omitted. Exemplary results of the laboratory research on this method and an interpretation of the results are presented.

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Laser tissue welding: A comprehensive review of current and future

Cited by 274 publications

References 131 publications

Tissue adhesives in ocular surgery

Tissue adhesives in ocular surgery

Laser‐mediated fixation of collagen‐based scaffolds to dermal wounds

Procedures of optical control dedicated for laser welding process of biological tissues

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