“…Regarding studies in animal models, the main effects of alcohol that have been evaluated are cognition, ataxia, hypothermia, and sedation. In the latter three, an age-dependent increase was observed when comparing adolescent, adult, and aged animals ( Matthews et al, 2019 ; Ornelas, Novier, Van Skike, Diaz-Granados, & Matthews, 2015 ; Perkins, Vore, Lovelock, Varlinskaya, & Deak, 2018 ; Silveri & Spear, 2000 ; Van Skike et al, 2010 ; Watson, James, Mittleman, & Matthews, 2020 ). In studies where the effects on cognition were tested, specifically spatial memory tests, no differences were observed between adolescent and adult animals following an acute dose of alcohol ( Chin et al, 2011 ; Matthews, Scaletty, Schreiber, & Trapp, 2020 ); however, aged animals did show impairment on memory tasks in general, both those assessing spatial and non-spatial memory ( Matthews et al, 2020 ).…”