Late Capsular Block Syndrome Associated With Propionibacterium acnes

Dhaliwal, Deepinder K.

doi:10.1001/archophthalmol.2010.356

Cited by 25 publications

(18 citation statements)

References 5 publications

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“…In the literature, although Propionibacterium acnes was isolated in late CBS cases 40 to 72 months after cataract surgery by pars plana needle aspiration, there were no clinical signs of endophthalmitis in these cases. According to previous studies, 15,16 late postoperative CBS can be treated with Nd:YAG capsulotomy, although caution to prevent the risk for endophthalmitis should be taken. Similarly, we have not encountered endophthalmitis clinically.…”

Section: Discussionmentioning

confidence: 99%

Late capsular block syndrome presenting with posterior capsule opacification

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Canan

et al. 2012

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 99%

Late capsular block syndrome presenting with posterior capsule opacification

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Canan

et al. 2012

Journal of Cataract and Refractive Surgery

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“…Several reports of late-onset CBS have also been verified to be related to Propionibacterium acnes ; hence, after posterior laser capsulotomy, P. acnes -associated endophthalmitis may occur [10, 11, 18, 19]. Moreover, posterior laser capsulotomy is difficult to perform because of opaque substance or severe expansion of the posterior capsule [12].…”

Section: Discussionmentioning

confidence: 99%

Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome

Huang

et al. 2017

Journal of Ophthalmology

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Purpose To further investigate the pathogenesis of late-onset capsular block syndrome (CBS) and to evaluate the safety of surgical treatment. Methods Seven patients diagnosed with late-onset CBS were retrospectively analyzed. Anterior chamber depth (ACD), intraocular pressure (IOP), refractive diopter, and best-corrected visual acuity (BCVA) before and after surgery were recorded. The opaque substance was tested with Western blot, and a flow cytometer multiple array assay system was utilized to evaluate the levels of inflammatory cytokines from opaque substance and aqueous humor, respectively. Results Patients who had undergone surgical treatment showed a significant BCVA and spherical equivalent refractive error improvement (P = 0.002, P = 0.021, resp.). Nevertheless, ACD and IOP before and after surgery were in normal range with no difference (P = 0.165, P = 0.749, resp.). αB-crystallin and βB-crystallin were detected in all opaque substances. Tumor necrosis factor-alpha (TNF-α) and interlukin-1β (IL-1β) levels in opaque substance were significantly higher than those in aqueous humor (P = 0.038, P = 0.007, resp.), while IL-2 and IL-6 were not detected in any samples. Conclusions Opaque substance is derived from human lens epithelial cells. Inflammatory cytokines may be involved in the pathogenesis of late-onset CBS. In addition, surgical treatment is an effective approach. This trial is registered with ChiCTR-IOR-17011287.

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“…[ 4 ] However, in isolated case reports, authors have also reported that upon the culture of the aspirated capsular bag fluid microbiological analysis has pointed to the possible role of P. acnes causing an indolent infection. [ 5 6 ] Although literature does not document any definite case of P. acnes associated endophthalmitis after release of fluid post Nd: YAG capsulotomy, to err on the side of caution and in view of poor posterior capsule visualization, we decided to go through pars plana approach using 25-gauge cutter to expedite the surgical process and to avoid possible spilling of potentially infectious fluid into the vitreous cavity. An isolated case report demonstrated the use of 23-gauge vitrectomy cutter to aspirate contents of capsular bag; however, in our case, we used 25-gauge instruments to make the procedure less traumatic and to avoid risk of postoperative hypotony secondary to wound leak.…”

Section: Discussionmentioning

confidence: 99%

A rare case of delayed onset capsular block syndrome managed using 25-gauge vitrector

et al. 2015

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We report a case of delayed onset capsular block syndrome in a patient 6 years after undergoing cataract surgery. Ocular examination revealed marked diminution of vision accompanied with a collection of milky fluid between the intraocular lens and posterior capsule. To treat and to understand the pathology of the condition, aspiration of fluid using 25-gauge vitrector through pars plana was done, and contents sent for microbiological analysis which did not reveal any growth. Postoperative period was uneventful with the absence of intraocular inflammation and excellent visual recovery.

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Late Capsular Block Syndrome Associated With Propionibacterium acnes

Cited by 25 publications

References 5 publications

Late capsular block syndrome presenting with posterior capsule opacification

Late capsular block syndrome presenting with posterior capsule opacification

Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome

A rare case of delayed onset capsular block syndrome managed using 25-gauge vitrector

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