2021
DOI: 10.3390/diagnostics11091615
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Late Changes in the Extracellular Matrix of the Bladder after Radiation Therapy for Pelvic Tumors

Abstract: Radiation therapy is one of the cardinal approaches in the treatment of malignant tumors of the pelvis. It leads to the development of radiation-induced complications in the normal tissues. Thus, the evaluation of radiation-induced changes in the extracellular matrix of the normal tissue is deemed urgent, since connective tissue stroma degradation plays a crucial role in the development of Grade 3–4 adverse effects (hemorrhage, necrosis, and fistula). Such adverse effects not only drastically reduce the patien… Show more

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