Late local recurrences in a randomised trial comparing conservative treatment with total mastectomy in early breast cancer patients

Abstract

Late breast recurrences were more frequently observed in younger patients treated with breast-conserving treatment compared with those submitted to mastectomy. These results require confirmation in other randomised studies so that younger patients with early breast cancer can receive adequate counselling and so that a more stringent long-term follow-up policy can be adopted when breast-conserving treatment is planned.

Are breast conservation and mastectomy equally effective in the treatment of young women with early breast cancer? Long-term results of a population-based cohort of 1,451 patients aged ≤40 years

“…The 10-year local relapse rate for women aged ≤40 years varies between 19% and 35% after BCT and between 7% and 12% after mastectomy [8,9,11,12,6]. In two previous reports concerning women ≤40 years we found 5-and 10-year actuarial local relapse rates of 9% and 17.9%, respectively, after BCT [13] and of 5.6% and 7.3% after mastectomy [14].…”

Long-term prognosis of patients with local recurrence after conservative surgery and radiotherapy for early breast cancer

“…Rates of local recurrence in the preserved breast vary between 2% and 10% after 5 years and between 5% and 15% at 10 years [1][2][3][4][5][6][7][8][9][10]. Considering the growing number of patients who have undergone BCT and the risk of local recurrence also extending after more than 10 years of follow-up, the number of patients experiencing a local recurrence is expected to increase considerably in the future.…”

Atrial Fibrillation and Cor Triatriatum Sinister: A Case Report

“…The cluster of therapies such as anthracycline-based chemotherapy, right-or left-sided RT, trastuzumab administration, and hormonal blockade with AIs may contribute to an increased incidence of CVD. [39][40][41][42][43][44][45][46][47][48]62,67,[153][154][155][156] In particular, there have been recent concerns calling for further investigation of targeted therapies used in combination with RT and the potential for long-term cardiovascular side effects. 92,147,154,157 Table 1 summarizes the potential longterm cardiovascular side effects of chemotherapy.…”

“…252 With this change came the increased use of RT as the preferred adjunctive approach in procedures that aim to conserve the breast. [59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75] Survival has increased with BCT and RT, and therefore the use of RT has grown exponentially. Long-term side effects of RT assume an increasingly important role in the development of SPMs.…”