Late metastases (beyond ten years) of cutaneous malignant melanoma

Raderman, David; Giler, S; Rothem, A.; Ben-Bassat, M

doi:10.1016/s0190-9622(86)70182-5

Cited by 33 publications

(18 citation statements)

References 15 publications

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“…This pattern was noted in our review of the literature and in the current case: 10/19 (52.6%; our case included) late local recurrences were in the lower extremity. Observations of Tsao, Briele, Raderman, and Levy et al found that the overwhelming majority of cases of late recurrence occurred in females, which was also reflected in our review (16/18, 89% or 17/19, 89.5% including our case) [1,8,28,29]. However, Tsao, et al previously addressed the issues of whether a selection bias exists due to the increased survival in general of women with melanoma [1].…”

Section: Discussionsupporting

confidence: 66%

The history of dermatology, venereology and dermatopathology in different countries - Argentina

Beguerie¹

2016

Glob Dermatol

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Section: Discussionsupporting

confidence: 66%

The history of dermatology, venereology and dermatopathology in different countries - Argentina

Beguerie¹

2016

Glob Dermatol

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“…As it is well established that melanoma can initially present as a metastasis even in the absence of a recognized primary cutaneous tumor [41,42], and that metastasis from a known cutaneous melanoma can develop after a prolonged disease-free interval [43][44][45], we performed a detailed review of the patients' medical records (including, where appropriate, questioning the patients about their history of melanoma) to assure that the clinical history of the study cases was accurate.…”

Section: Study Casesmentioning

confidence: 99%

EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma

et al. 2005

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“…Einige Autoren vermuten, meist auf Grund von Einzelfallinterpretationen [4,7,20,30], daß Frauen häufiger Spät-metastasen entwickeln als Männer. Als zusätzlicher Einflußfaktor wurde die Prämenopause diskutiert [4,30].…”

Section: Malignant Melanoma · Late Metastasesunclassified

“…Als zusätzlicher Einflußfaktor wurde die Prämenopause diskutiert [4,30]. Grö-ßere Studien und auch unsere Ergebnisse können beides nicht bestätigen [8,9,36].…”

Section: Malignant Melanoma · Late Metastasesunclassified

“…Dem entsprechen auch unsere Befunde. Die Aussage, daß Spätmetastasen bevorzugt bei Primärtumorsitz an den unteren Extremitäten auftreten [4,7,20,30], beruht wiederum nur auf Einzelfallbeobachtungen. An größeren Kollektiven zeigt sich, daß Rumpf-und Beinmelanome in der Metastasengruppe gleich stark vertreten, allerdings geschlechtsspezifisch unterschiedlich verteilt sind [9,19,36].…”

Section: Malignant Melanoma · Late Metastasesunclassified

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Melanomerstmetastasen nach 10 und mehr Jahren Erscheinungsfreiheit

1997

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36 (3.5%) of 1015 patients who had ten or more years of follow-up after treatment of invasive malignant melanomas (stage I and II, UICC 1978) in Hornheide 1967-1984 developed late metastases. The mean disease-free interval was 12.5 years. These patients were younger (mean age of 45.8 years) compared to the age of all melanoma patients at the time of primary therapy. The rate of late relapses was 2.8% in women (20/705) and 5% in men (16/310). In melanomas located on the trunk or on the legs in male individuals, the relapse was twice as high as in females. The median tumor thickness in patients with late progression was 1.5 mm; in patients without relapse 1.2 mm. The well known association of tumor thickness with the risk of metastases disappeared after a 10 years disease-free interval. The frequency of metastases (3.5%) did not vary in different thickness classes from 0.76 mm to 3 mm or more. Melanomas with a Breslow thickness < 0.75 mm had a risk of only 1.4%. 23 patients (64%) developed distant, only 13 (36%) regional late metastases as first evidence of recurrent disease. The survival of these patients correlated neither to the duration of previous relapse-free follow up, nor to site of the primary lesion nor to sex. It correlated only to the site of metastases: 83% of all patients with distant late metastases had a remaining life time of 14 months or less, but patients with regional metastases survived more than 7 years in 69% of the cases. We have been unable to define risk factors for late metastases.

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Late metastases (beyond ten years) of cutaneous malignant melanoma

Cited by 33 publications

References 15 publications

The history of dermatology, venereology and dermatopathology in different countries - Argentina

The history of dermatology, venereology and dermatopathology in different countries - Argentina

EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma

Melanomerstmetastasen nach 10 und mehr Jahren Erscheinungsfreiheit

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