Late pregnancy is vulnerable period for exposure to BPA

Ohtani, Naoko; Suda, Koshi; Tsuji, Erika; Tanemura, Kentaro; Yokota, Hiroshi; Inoue, Hiroki; Iwano, Hidetomo

doi:10.1292/jvms.17-0460

Cited by 20 publications

(11 citation statements)

References 68 publications

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“…During the gestational period, any exposure to EDCs may cause an alteration to the fetus, as many of these chemicals can cross the placenta [ 8 ]. Findings from animal studies suggest that the effect of EDC exposure on developmental and neurobehavioral outcomes may have critical periods [ 9 , 10 ]. As bisphenol A and phthalates are EDCs, they may have an impact on the development of sexually dimorphic brain structures prenatally.…”

Section: Introductionmentioning

confidence: 99%

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Minatoya

Kishi

2021

IJERPH

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Purpose of Review: Bisphenol A and phthalate have been found in the environment, as well as in humans. In this narrative review pre- and postnatal bisphenol A and phthalate exposures, their relationship to neurodevelopment, and the behavioral outcomes of children are elucidated, focusing in particular on the recent case-control, cross-sectional, and longitudinal studies. This review also introduces some of the possible mechanisms behind the observed associations between exposures and outcomes. Recent Findings: Although bisphenol A and phthalate exposure have been reported to influence neurobehavioral development in children, there are various kinds of test batteries for child neurodevelopmental assessment at different ages whose findings have been inconsistent among studies. In addition, the timing and number of exposure assessments have varied. Summary: Overall, this review suggests that prenatal exposure to bisphenol A and phthalates may contribute to neurobehavioral outcomes in children. The evidence is still limited; however, Attention Deficit Hyperactivity Disorder (ADHD) symptoms, especially among boys, constantly suggested association with both prenatal and concurrent exposure to bisphenol A. Although there is limited evidence on the adverse effects of prenatal and postnatal bisphenol A and phthalate exposures provided, pregnant women and young children should be protected from exposure based on a precautionary approach.

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Section: Introductionmentioning

confidence: 99%

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Minatoya

Kishi

2021

IJERPH

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“…Similarly, knowledge among workers of both sexes on possible effects of ED on their fertility is certainly not better. While for some effects, late pregnancy might be the most critical time period [ 13 ], other effects are of higher concern if exposure occurs in early pregnancy [ 14 , 15 ] or even before the woman is aware of her pregnancy. These early developmental exposures could have long lasting effects in the offspring [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry: A New Paradigm in Occupational Health

Fučić

Galea

Duca

et al. 2018

IJERPH

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Endocrine disruptors (EDs) belong to large and diverse groups of agents that may cause multiple biological effects associated with, for example, hormone imbalance and infertility, chronic diseases such as diabetes, genome damage and cancer. The health risks related with the exposure to EDs are typically underestimated, less well characterized, and not regulated to the same extent as, for example, carcinogens. The increased production and utilization of identified or suspected EDs in many different technological processes raises new challenges with respect to occupational exposure settings and associated health risks. Due to the specific profile of health risk, occupational exposure to EDs demands a new paradigm in health risk assessment, redefinition of exposure assessment, new effects biomarkers for occupational health surveillance and definition of limit values. The construction and plastics industries are among the strongest economic sectors, employing millions of workers globally. They also use large quantities of chemicals that are known or suspected EDs. Focusing on these two industries, this short communication discusses: (a) why occupational exposure to EDs needs a more specific approach to occupational health risk assessments, (b) identifies the current knowledge gaps, and (c) identifies and gives a rationale for a future occupational health paradigm, which will include ED biomarkers as a relevant parameter in occupational health risk assessment, surveillance and exposure prevention.

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“…Bisphenol A (BPA; 2,2-bis [4-hydroxyphenyl]propane) is an industrial chemical widely used in the manufacture of polycarbonate plastics and epoxy resin liners for aluminum cans [1][2][3][4][5][6][7]. BPA is an endocrine-disrupting chemical (EDC) that has been demonstrated to affect reproductive organ development [7][8][9], brain development [10][11][12][13][14][15], metabolic diseases [16], and postnatal behavior [17][18][19]. These adverse effects are thought to be due to disturbed signaling mechanisms involving estrogen, androgen, and thyroid hormone.…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of Bisphenol A and Its Adverse Effects on the Next Generation

Iwano¹,

Inoue²,

Nishikawa³

et al. 2018

Endocrine Disruptors

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Although we are exposed to many chemical substances in routine daily life, the body has metabolic systems capable of detoxifying and eliminating these chemicals. Bisphenol A (BPA) is an endocrine disrupter of great concern because of its estrogenic activity, but studies have indicated no severe adverse effects in adult rodents exposed to BPA due to metabolic detoxification. BPA is metabolized by glucuronidation mediated by phase II enzymes such as UDP-glucuronosyltransferase. Numerous recent studies in rodents have indicated that maternal BPA exposure causes adverse effects in offspring. It was also shown that bisphenol analogs are efficiently absorbed via the oral route and distributed to the reproductive tract in pregnant rats, with its residue capable of crossing the placental barrier in the late stage of gestation. Both animal and human studies have demonstrated that BPA and the BPA metabolite BPA-GA are detectable in fetal and amniotic fluid, suggesting the presence of a placental transfer mechanism. In this review, we discuss the pharmacokinetics of BPA, particularly its (1) metabolism and disposition in the intestine, (2) metabolism and disposition in the liver, and (3) transfer from maternal tissues to the fetus.

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Late pregnancy is vulnerable period for exposure to BPA

Cited by 20 publications

References 68 publications

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry: A New Paradigm in Occupational Health

Biotransformation of Bisphenol A and Its Adverse Effects on the Next Generation

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