Late Prosthetic Joint Infection and Bacteremia by <i>Bacillus cereus</i> Confirmed by 16S rRNA Sequencing and Hip Joint Tissue Pathology

Ha, Jihye; Park, Yu Jin; Kim, Yee Jeong; Oh, Hyun Cheol; Kim, Young Ah

doi:10.5145/acm.2016.19.2.54

Cited by 4 publications

(10 citation statements)

References 15 publications

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“… 4 Except for B. cereus and B. anthracis , the genus Bacillus is rarely associated with disease. 3 , 5 , 6 , 7 Therefore, Bacillus species are often reported as contaminants, even when cultured from sterile specimens. This may result in a delay in correct diagnosis and inappropriate treatment.…”

Section: Discussionmentioning

confidence: 99%

“…However, identification to species level requires specialised techniques such as matrix-assisted laser desorption/ionisation mass spectrometry or molecular techniques. 7 …”

Section: Discussionmentioning

confidence: 99%

“…Musculoskeletal infections caused by B. cereus are rare but have been previously reported in literature. 4 , 5 , 6 , 7 Åkesson, Hedströum and Ripa. 4 reported 12 cases of B. cereus orthopaedic infections, all occurring in post-operative or post-traumatic wounds, whilst Dubouix et al 5 reported 41 cases with B. cereus wound infections associated with open fractures.…”

Section: Discussionmentioning

confidence: 99%

“… 3 The empiric antibiotic of choice for invasive B. cereus infections is vancomycin. 3 , 7 In addition to administering antibiotics, it is imperative to obtain source control at the infected site, as B. cereus is known to form biofilm. The removal of implanted medical devices may be necessary.…”

Section: Discussionmentioning

confidence: 99%

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Post-procedural Bacillus cereus septic arthritis in a patient with systemic lupus erythematosus

Mitton¹,

Rule²,

Mbelle³

et al. 2020

African Journal of Laboratory Medicine

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Introduction: Bacillus species are often considered as contaminants when cultured from clinical samples. Bacillus cereus may be a pathogen in certain circumstances and is known to cause musculoskeletal infections. This report aims to educate clinicians and clinical microbiology laboratories on B. cereus musculoskeletal infections and to heighten awareness that Bacillus species should not always be dismissed as contaminants.Case presentation: We report the case of a patient who presented to a tertiary hospital in Pretoria, South Africa, in November 2018 with B. cereus septic arthritis and underlying systemic lupus erythematosus (SLE). The isolate would otherwise have been dismissed as a contaminant had it not been for the crucial interaction between the laboratory and the treating clinicians. To our knowledge, this is the first case report of septic arthritis caused by B. cereus in an SLE patient where the organism was cultured from the joint specimen. Identification of the organism was performed using matrix-assisted laser desorption/ionisation mass spectrometry.Management and outcome: Definitive treatment was with intravenous vancomycin, continued for four weeks, in addition to arthroscopy and management of the underlying SLE. The patient had a good clinical outcome and regained full mobility.Conclusion: Musculoskeletal infections, specifically septic arthritis caused by B. cereus, are exceedingly rare infections. Immune suppression, trauma, prosthetic implants and invasive procedures are important risk factors for B. cereus musculoskeletal infections. Close collaboration with a multi-disciplinary team approach will effect the best outcome for complicated patients with B. cereus infections.

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Section: Discussionmentioning

confidence: 99%

“…However, identification to species level requires specialised techniques such as matrix-assisted laser desorption/ionisation mass spectrometry or molecular techniques. 7 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Post-procedural Bacillus cereus septic arthritis in a patient with systemic lupus erythematosus

Mitton¹,

Rule²,

Mbelle³

et al. 2020

African Journal of Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…Bacillus intestinalis strain 1731 is an aerobic, spore-forming, motile, Gram-positive, rod-shaped bacterium that was isolated from the small intestine of a patient with intestinal malignancy. The members of the Bacillaceae family are well-known representatives of the human gut microbiota and are implicated in a number of pathologies ( 1 – 3 ). Using combined culture and genetic workflow, we have previously identified the unexplored diversity of endospore-forming bacteria within humans; this identification necessitated the characterization of spore-forming bacteria, such as Sporobiota spp., and the collection of their genes as a sporobiome, owing to their unique common characteristics ( 4 – 6 ).…”

Section: Genome Announcementmentioning

confidence: 99%