Late pulmonary metastases from malignant melanoma of the left planta

Toba, Hiroaki; Kondo, Kazuya; Kenzaki, Koichiro; Miyoshi, Takanori; Shoji, Shuichi; Tangoku, Akira

doi:10.1007/s11748-009-0438-9

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…More than 80% of patients with metastatic melanoma initially show only one distant organ site involved. The lung is the most common organ involved, with about 40% of patients showing isolated pulmonary metastasis [3,5,11-13]. Metastatic melanoma is usually associated with a dismal prognosis.…”

Section: Discussionmentioning

confidence: 99%

Complete Resection of Pulmonary Metastatic Melanoma

Kim

Park

Wang

2011

Korean J Thorac Cardiovasc Surg

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BackgroundThe prognosis of melanoma metastasized to other organs is very poor. There have been many studies on metastatic melanoma in Western society, but there have been few studies done in Korea because of the small number of cases.Materials and MethodsA retrospective review of 7 patients who underwent complete resection of pulmonary metastases from melanoma from January 2005 to December 2009 was performed. When the primary lesion was controlled or simultaneously controllable and no other metastatic lesion was found, pulmonary resections were performed. We analyzed the clinical prognoses after the initial melanoma diagnosis.ResultsOf the seven patients, one was male and six were female. The mean age was 58.2 years (range 45~71). Six patients had a single pulmonary lesion and one patient had three lesions confined to the same lobe. The mean disease-free interval was 43.5 months (0~146 months). Before pulmonary resection, 4 patients had received systemic therapy. After pulmonary resection, 6 patients received systemic therapy. Complete resection was confirmed histologically. The metastasectomy was performed by wedge resection (6 patients) or lobectomy (1 patient). There were no mortalities or complications. After pulmonary resection, 1 patient had recurrent multiple lesions in the lung and 4 patients had metastases to other organs. The organs were the liver, brain, pleura, and lymph nodes. The mean observation time was 31.6 months and 3 patients died during observation. The mean survival was 27.7 months (14~60 months) and the 1-year and 3-year survival rates were 100% and 42%, respectively.ConclusionWhen patients were selected carefully, the complete resection of pulmonary metastatic lesions was considered a major therapeutic tool.

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Section: Discussionmentioning

confidence: 99%

Complete Resection of Pulmonary Metastatic Melanoma

Kim

Park

Wang

2011

Korean J Thorac Cardiovasc Surg

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Late Metastatic Melanoma after 25 Years: A Case Report and a Brief Literature Review

Pescarini

Spanikova

Mbaidjol

et al. 2020

Case Reports in Surgery

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The incidence of cutaneous malignant melanoma has shown a drastic increase over recent decades, and approximately 70% of newly diagnosed melanoma are tumors with a Breslow thickness less or equal to 1 mm. In the literature, there are well-documented rare cases of late metastasis of thin melanoma, and given their growing incidence, it is expected in the future to see more cases of late recurrence. We present a case report of a metastatic cutaneous melanoma 25 years from diagnosis and a review of the literature. A 61-year-old female patient presented with a newly discovered asymptomatic nodule on her thigh. Her relevant past medical history included a completely excided lesion with Breslow 1.4 mm thickness in 1989 for which she was followed up according to the guidelines and subsequently declared cured after 10 years of surveillance. Fine-needle aspiration and cytological analysis of the lesion proved to be a subcutaneous localization of malignant melanoma. The lesion was completely excised, and the patient has remained disease free since her surgery. The aim of this case report is to emphasize that late metastasis remains uncommon but a definitive cure from melanoma cannot always be considered a disease-free interval of 10 years. Physicians should always be aware of previous melanoma diagnosis with newly discovered suspicious lesions. Better patient education could improve the detection of recurrence and secondary melanomas without any need for more frequent follow-up visits and a prolonged follow-up time.

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