Lateral resolution in NALDI MSI: back to the future

Krásný, Lukáš; Benada, Oldřich; Strnadová, Marcela; Lemr, Karel; Havlı́ček, Vladimı́r

doi:10.1007/s00216-014-8294-6

Cited by 8 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The investigation of the nature of interactions arising when pulsed laser radiation hits a nanostructure is an almost unexplored field in LDI-MS. More frequently, microscopy techniques (e.g., atomic force microscopy—AFM, scanning electron microscopy—SEM) have been applied for the characterization of LDI nanostructured substrates, before and after laser irradiation [39,54,69,77,79,105,106]. However, “in situ” techniques as well as theoretical modelling would be important to study the process.…”

Section: Promising Methods To Study Laser Radiation-nanophase Intementioning

confidence: 99%

Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

et al. 2017

View full text Add to dashboard Cite

Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental aspects of the ion desorption efficiency and the internal energy transfer, in the case of model analytes. Several different parameters have been investigated, including the intrinsic chemical and physical properties of the nanophase (chemical composition, thermal conductivity, photo-absorption efficiency, specific heat capacity, phase transition point, explosion threshold, etc.), along with morphological parameters such as the nanophase size, shape, and interparticle distance. Other aspects, such as the composition, roughness and defects of the substrate supporting the LDI-active nanophases, the nanophase binding affinity towards the target analyte, the role of water molecules, have been taken into account as well. Readers interested in nanoparticle based LDI-MS sub-techniques (SALDI-, SELDI-, NALDI- MS) will find here a concise overview of the recent findings in the specialized field of fundamental and mechanistic studies, shading light on the desorption ionization phenomena responsible of the outperforming MS data offered by these techniques.

show abstract

Section: Promising Methods To Study Laser Radiation-nanophase Intementioning

confidence: 99%

Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

et al. 2017

View full text Add to dashboard Cite

show abstract

“…More specific details on NALDI approach can be found in literature. 22 The acquired data were processed by FlexImaging 4.1 and DataAnalysis 4.4 software (Bruker Daltonics) without any data normalization. Detected ions were searched against in-house Cyclobranch software (http://ms.biomed.cas.cz/cyclobranch) 25 and SciFinder databases (http://www.cas.org/products/scifinder).…”

Section: Methodsmentioning

confidence: 99%

“…20 The use of silicon nanowires, 21 which was also commercialized as nanostructure-assisted laser desorption ionization (NALDI) technique, has become popular in the analysis of small organic molecules. [22][23][24] In this work, we present NALDI imaging in visualizing the latent fingerprints including the possibility of direct detection of illicit drugs during one image analysis. The results from NALDI imaging were compared with the MALDI and DESI-MSI, and the specific contribution of all techniques is discussed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mass spectrometry imaging of illicit drugs in latent fingerprints by matrix-free and matrix-assisted desorption/ionization techniques

Škríba

Havlı́ček

2017

Eur J Mass Spectrom (Chichester)

Self Cite

View full text Add to dashboard Cite

Compared with classical matrix-assisted laser-desorption ionization mass spectrometry (MALDI), the matrix free-based strategies generate a cleaner background, without significant noise or interference coming from an applied matrix, which is beneficial for the analysis of small molecules, such as drugs of abuse. In this work, we probed the detection efficiency of methamphetamine, heroin and cocaine in nanostructure-assisted laser desorption-ionization (NALDI) and desorption electrospray ionization and compared the sensitivity of these two matrix-free tools with a standard MALDI mass spectrometry experiment. In a typical mass spectrometry imaging (MSI) setup, papillary line latent fingerprints were recorded as a mixture a common skin fatty acid or interfering cosmetics with a drug. In a separate experiment, all drugs (1 µL of 1 μM standard solution) were detected by all three ionization techniques on a target. In the case of cocaine and heroin, NALDI mass spectrometry was the most sensitive and revealed signals even from 0.1 μM solution. The drug/drug contaminant (fatty acid or cosmetics) MSI approach could be used by law enforcement personnel to confirm drug abusers of having come into contact with the suspected drug by use of fingerprint scans at time of apprehension which can aid in reducing the work of lab officials.

show abstract

“…Porous silicon (Ronci et al, 2012;Rudd et al, 2015), Commercial NALDI target (Krasny et al, 2015;Skriba & Havlicek, 2018;Tata et al 2012Tata et al , 2014Vidova et al 2010), Silica plate (De Oliveira et al, 2014), AuBSi (Iakab et al, 2020) Silicon nanopost array (Fincher et al, 2019a(Fincher et al, , 2019b(Fincher et al, , 2020a(Fincher et al, , 2020bStopka et al, 2016), Silica plate (Ferreira et al, 2014), (Modified) etched silicon (Guinan et al, 2015c;Liu et al, 2007;O'Brien et al, 2013;Patti et al 2010b;Yanes et al, 2009), SiO 2 NPs (Dupré et al, 2012) Pure metal: Au (Chau et al, 2017;Dufresne et al, 2016;Hansen et al, 2019;...…”

mentioning

confidence: 99%

Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review

Müller

Verdin

Pauw

et al. 2020

Mass Spectrometry Reviews

View full text Add to dashboard Cite

In the last decades, surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has attracted increasing interest due to its unique capabilities, achievable through the nanostructured substrates used to promote the analyte desorption/ionization. While the most widely recognized asset of SALDI-MS is the untargeted analysis of small molecules, this technique also offers the possibility of targeted approaches. In particular, the implementation of SALDI-MS imaging (SALDI-MSI), which is the focus of this review, opens up new opportunities. After a brief discussion of the nomenclature and the fundamental mechanisms associated with this technique, which are still highly controversial, the

show abstract

Lateral resolution in NALDI MSI: back to the future

Cited by 8 publications

References 28 publications

Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

Mass spectrometry imaging of illicit drugs in latent fingerprints by matrix-free and matrix-assisted desorption/ionization techniques

Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review

Contact Info

Product

Resources

About