Lateral Specialization of Cerebral Function in the Surgically Separated Hemispheres

Sperry, R. W.

doi:10.1016/b978-0-12-484050-8.50012-1

Cited by 290 publications

(273 citation statements)

References 17 publications

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“…Previous neuropsychological, task-fMRI and anatomical studies have, for example, reported that attention is dominant in the right hemisphere (Sperry 1974;Mesulam 1999;Shulman et al 2010;Thiebaut de Schotten et al 2011). Also, the right hemispheric hypoarousal theory of ADHD has long suggested that inattention and impulsivity associated with ADHD is due to a lateralised disturbance in frontal lobe network function, mediated by the dysfunction of predominantly right hemispheric frontostriatal (Sheppard et al 1999) and frontoparietal tracts (Carter et al 1995).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Sanefuji

Craig

Parlatini

et al. 2017

Cortex

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Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Sanefuji

Craig

Parlatini

et al. 2017

Cortex

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“…That the right hemisphere is specialized for visuospatial attention has long been argued on the basis of neuropsychological dissociations in split-brain (e.g., Sperry, 1974) and neglect (e.g., Kinsbourne, 1987;Mesulam, 1981) patients, as well as the neuroimaging results discussed above. Consistent findings have also come from studies using transcranial magnetic stimulation (TMS; Bjoertomt, Cowey, & Walsh, 2002;Oliveri & Vallar, 2009) and voxel-based lesionsymptom mapping (Verdon et al, 2010).…”

Section: Spatial Attention and The Right Hemispherementioning

confidence: 99%

Right hemisphere control of visuospatial attention in near space

et al. 2015

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“…The split-brain research pioneered by Sperry [30,31]ushered in attempts to interpret humans' thought process in terms of the functions of the two cerebral hemispheres, in accordance with early theories of cerebral lateralization. Creative activities and intuition have been thought to be attributable to the right brain function [8].…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Enigma of Human Creativity: Can a Digital Computer Think?

Hong¹

2013

J Comput Sci Syst Biol

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The objective of the present article is a) to explain humans' high creativity in non-mystic and unambiguous terms, b) to evaluate the performance of problem-solving computer programs and c) to make suggestions about future designs of heuristics. Unlike many previous attempts in the past century, we sought inspiration from two sources that had been neglected or excluded from considerations by experts: artificial intelligence and introspections of a number of highly creative individuals, who confessed that they had a penchant for visual thinking. Simonton's chance-configuration model was refurbished accordingly. It is now possible for the refurbished model to explain a number of outstanding puzzles that had eluded our predecessors: a) what intuition is, b) why creators had no idea about their source of inspiration even after the fact, c) a peculiar event happening at the discovery time, known as the "aha" phenomenon, d) a type of accidental discoveries known as serendipity. Moreover, the elusive concept of abduction advanced by philosopher Charles Peirce is actually visual thinking in disguise. Blessed with this new understanding, we could evaluate the performance of a number of problem-solving computer programs from a cognitive point of view. It turned out that the common thread that links human creativity and computerbased creative problem solving is heuristic searching. Recognizing that a digital computer must perform heuristic searching in a digital environment, which is not the most user-friendly environment to do so, we made suggestions about how to circumvent the restrictions without sacrificing the principles in future designs of heuristics.

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Lateral Specialization of Cerebral Function in the Surgically Separated Hemispheres

Cited by 290 publications

References 17 publications

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Right hemisphere control of visuospatial attention in near space

Deciphering the Enigma of Human Creativity: Can a Digital Computer Think?

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