Lateral Temporal Bone Resection in Advanced Cutaneous Squamous Cell Carcinoma: Report of 35 Patients

Essig, Garth; Kitipornchai, Leon; Adams, Felicity; Zarate, Dannie; Gandhi, Mitesh; Porceddu, Sandro; Panizza, Benedict

doi:10.1055/s-0032-1331021

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…Ensuring that the margin is tumor-free after surgical resection is important. Essig et al [ 15 ] reported a DFS rate of 81% at 2 years in patients with clear margins, in contrast to a DFS rate of 45% in patients with positive margins. Moody et al [ 1 ] also reported that positive histological margins were associated with reduced survival at 2 years (32%) compared to that of patients with clear margins (75%) [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…The survival rates of patients with SCCs of the EAC who undergo surgery at early stages are reportedly favorable, highlighting the importance of clinical suspicion and early diagnosis. The results of our study have been summarized along with the results of contemporary series in Table 4 [ 1 , 3 , 4 , 6 - 10 , 12 , 14 , 15 , 23 - 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Factors Affecting Surgical Outcomes in Squamous Cell Carcinoma of External Auditory Canal

Nam

Moon

Kim

et al. 2018

Clin Exp Otorhinolaryngol

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Objectives Carcinomas of the external auditory canal (EAC) are rare, and management remains challenging. Previous studies seeking prognostic factors for EAC cancers included cancers other than carcinomas. In this study, we analyzed the treatment outcomes of, prognostic factors for, and survival rates associated with specifically squamous cell carcinoma (SCC) of the EAC.Methods A retrospective review of 26 consecutive patients diagnosed with SCCs of the EAC in a 10-year period was performed in terms of clinical presentation, stage, choice of surgical procedure, and adjunct therapy. Overall survival (OS) and recurrence-free survival (RFS) were calculated and univariate analysis of prognostic factors was performed.Results The median age of the 26 patients with SCCs of the EAC was 63 years (range, 40 to 72 years), and 16 males and 10 females were included. According to the modified University of Pittsburgh staging system, the T stages were T1 in 11, T2 in six, T3 in four, and T4 in five cases. The surgical procedures employed were wide excision in three cases, lateral temporal bone resection (LTBR) in 17, and extended LTBR in four, and subtotal temporal bone resection in two. Two patients underwent neoadjuvant chemotherapy, and two underwent adjuvant chemotherapy. One patient received preoperative radiation therapy, and eleven received postoperative radiation therapy. Of the possibly prognostic factors examined, advanced preoperative T stage and advanced overall stage were significant predictors of RFS, but not of OS.Conclusion The advanced T stage and overall stage were associated with decreased survival after surgical treatment in patients with SCC of the EAC, highlighting the importance of clinical vigilance and early detection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic Factors Affecting Surgical Outcomes in Squamous Cell Carcinoma of External Auditory Canal

Nam

Moon

Kim

et al. 2018

Clin Exp Otorhinolaryngol

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“…In general, postoperative RT has been performed after radical surgery such as STBR or total temporal bone resection (TTBR) for stage T4 EAC cancer. In previous studies that analyzed the prognosis of T3 and T4 stages of TB SCC, a 5‐year DSS was 45%–65% 6,24,25 . The 2‐year OS was 50%–64% at T3 stage and 7%–49% at T4 stage 1,16,26,27 .…”

Section: Discussionmentioning

confidence: 93%

“…In previous studies that analyzed the prognosis of T3 and T4 stages of TB SCC, a 5-year DSS was 45%-65%. 6,24,25 The 2-year OS was 50%-64% at T3 stage and 7%-49% at T4…”

Section: Discussionmentioning

confidence: 99%

Treatment outcomes of the external auditory canal and temporal bone malignancy with dura invasion

Lee

Jeong

Chung

2023

Laryngoscope Investig Oto

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ObjectivesThis study aimed to evaluate the characteristics and surgical outcomes of patients with external auditory canal (EAC) and temporal bone (TB) malignancy with dura invasion.MethodsThe medical records of patients with EAC and TB malignancy with dura invasion were retrospectively reviewed. Survival outcomes (overall survival [OS], disease‐specific survival [DSS], recurrence‐free survival [RFS], and distant metastasis‐free survival [DMFS]) were analyzed using the Kaplan–Meier method.ResultsA total of eight patients were included in this study. The median age at diagnosis was 49.5 years (range 12–74 years). The median follow‐up periods were 46.5 months. Histologically, four out of eight patients were diagnosed with squamous cell carcinoma (SCC; 50%). The 2‐year OS and DSS rates of all patients were 62.5%, and those of EAC SCC patients were 50% and 66.7%, respectively; while the 2‐year RFS and DMFS rates of all patients were 37.5%. There was one local recurrence at the resection site (12.5%), two regional neck nodal recurrences (25%), and two distant metastases (25%). Dura resection and duroplasty areas were not involved in the local recurrence case.ConclusionIn EAC and TB cancer with dura invasion, radical surgery with dura resection may show similar survival outcomes to previous studies without recurrence at the dura resection site.Level of evidence: IV

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“…This approach has shown improved locoregional control in cases of locally advanced parotid and cutaneous malignancies. [942][943][944][945]…”

Section: Advanced Skin and Parotid Gland Malignancymentioning

confidence: 99%

Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition

Homer,

Winter,

Abbey

et al. 2024

J. Laryngol. Otol.

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Lateral Temporal Bone Resection in Advanced Cutaneous Squamous Cell Carcinoma: Report of 35 Patients

Cited by 13 publications

References 31 publications

Prognostic Factors Affecting Surgical Outcomes in Squamous Cell Carcinoma of External Auditory Canal

Prognostic Factors Affecting Surgical Outcomes in Squamous Cell Carcinoma of External Auditory Canal

Treatment outcomes of the external auditory canal and temporal bone malignancy with dura invasion

Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition

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